Nptxr MGI Mouse Gene Detail - MGI:1920590 - neuronal pentraxin receptor

Symbol

Nptxr
Name

neuronal pentraxin receptor
Synonyms

1200009K17Rik, 1700036C17Rik, 5730406O18Rik, D15Bwg0580e, NPCD, NPR

Feature Type

protein coding gene
IDs

MGI:1920590
NCBI Gene: 73340
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr15:79670552-79688910 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 37.85 cM, cytoband E2
Mapping Data

5 experiments

SNPs within 2kb

529 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920590	protein coding gene	Chr15:79670552-79688967 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022086	protein coding gene	Chr15:80083588-80101961 (-)
A/J	MGP_AJ_G0022047	protein coding gene	Chr15:77310211-77328585 (-)
AKR/J	MGP_AKRJ_G0022022	protein coding gene	Chr15:79471379-79489753 (-)
BALB/cJ	MGP_BALBcJ_G0022053	protein coding gene	Chr15:77323918-77342292 (-)
C3H/HeJ	MGP_C3HHeJ_G0021824	protein coding gene	Chr15:79461017-79479391 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022496	protein coding gene	Chr15:83233333-83251753 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020026	protein coding gene	Chr15:73795326-73813756 (-)
CAST/EiJ	MGP_CASTEiJ_G0021345	protein coding gene	Chr15:80179313-80197693 (-)
CBA/J	MGP_CBAJ_G0021789	protein coding gene	Chr15:85831174-85849546 (-)
DBA/2J	MGP_DBA2J_G0021918	protein coding gene	Chr15:76798477-76816847 (-)
FVB/NJ	MGP_FVBNJ_G0021896	protein coding gene	Chr15:75825085-75843447 (-)
LP/J	MGP_LPJ_G0021986	protein coding gene	Chr15:80271518-80289903 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021916	protein coding gene	Chr15:90923610-90941997 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022510	protein coding gene	Chr15:79500220-79520684 (-)
PWK/PhJ	MGP_PWKPhJ_G0021087	protein coding gene	Chr15:76809698-76828122 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020924	protein coding gene	Chr15:79299142-79317473 (-)
WSB/EiJ	MGP_WSBEiJ_G0021397	protein coding gene	Chr15:79885766-79905153 (-)

Human Ortholog

NPTXR, neuronal pentraxin receptor

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NPTXR, neuronal pentraxin receptor
Synonyms

NPR
Links

HGNC:7954

NCBI Gene ID: 23467

neXtProt AC: NX_O95502

UniProt: O95502
Chr Location

22q13.1; chr22:38818452-38844028 (-) GRCh38

MGI Vertebrate Homology

Nptxr stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NPTXR
Gene Tree

Nptxr

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

2
Targeted

4
Genomic Mutations

3 involving Nptxr
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

9 strains or lines available

Mice homozygous for a null mutation of this gene display a mild alteration in retinal ganglion cell innervation but are fertile with no obvious behavioral abnormalities.

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All GO Annotations

14
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

731
Tissues

16
cDNA Data

13
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nptxr

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All Sequences

52
RefSeq

2
UniProt

7
CCDS

CCDS27653.1

Ensembl

ENSMUSG00000022421 (Evidence)
NCBI Gene

73340

			Length	Strain/Species	Flank
genomic	73340	NCBI Gene Model \| MGI Sequence Detail	18359	C57BL/6J	± kb
transcript	NM_030689	RefSeq \| MGI Sequence Detail	4973	C57BL/6
polypeptide	Q99J85	UniProt \| EBI \| MGI Sequence Detail	493	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000011384 neuronal pentraxin receptor

(term hierarchy)
InterPro Domains

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR051360 Neuronal Pentraxin and Related

IPR030476 Pentaxin, conserved site

IPR001759 Pentraxin-related
GlyGen

Q99J85 3 sites, 6 N-linked glycans (2 sites)

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All nucleic 15

Genomic 1

cDNA 13

Primer pair 1

Microarray probesets 4

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MGD-MRK-34009, MGI:106317, MGI:1921368, MGI:1921988, MGI:2146019, MGI:2146057

Summaries

All 60

Developmental Gene Expression 4

Diseases 1

Gene Ontology 5

Phenotypes 27
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:341574 Kanda M, et al., Therapeutic monoclonal antibody targeting of neuronal pentraxin receptor to control metastasis in gastric cancer. Mol Cancer. 2020 Aug 26;19(1):131

TSS for Nptxr:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135389	Chr15:79688918-79688933 (-)	-16 bp
Tssr135388	Chr15:79688912-79688917 (-)	-5 bp
Tssr135387	Chr15:79688656-79688704 (-)	230 bp
Tssr135386	Chr15:79688426-79688442 (-)	476 bp
Tssr135385	Chr15:79675145-79675152 (-)	13,761 bp
Tssr135384	Chr15:79673829-79673842 (-)	15,074 bp
Tssr135383	Chr15:79673242-79673258 (-)	15,660 bp
Tssr135382	Chr15:79671078-79671086 (-)	17,828 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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