Actrt1 MGI Mouse Gene Detail - MGI:1920610

Symbol

Actrt1
Name

actin-related protein T1
Synonyms

1700061J02Rik, Arp-T1

Feature Type

protein coding gene
IDs

MGI:1920610
NCBI Gene: 73360
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

ChrX:45417884-45419222 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 24.54 cM, cytoband A3.1
Mapping Data

3 experiments

SNPs within 2kb

71 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920610	protein coding gene	ChrX:45417884-45419222 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035683	protein coding gene	ChrX:41447143-41448481 (+)
A/J	MGP_AJ_G0035666	protein coding gene	ChrX:41312103-41313441 (+)
AKR/J	MGP_AKRJ_G0035586	protein coding gene	ChrX:42412087-42413425 (+)
BALB/cJ	MGP_BALBcJ_G0035652	protein coding gene	ChrX:41049775-41051113 (+)
C3H/HeJ	MGP_C3HHeJ_G0035356	protein coding gene	ChrX:41750804-41752142 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036181	protein coding gene	ChrX:42426106-42427444 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033033	protein coding gene	ChrX:39136722-39138060 (+)
CAST/EiJ	MGP_CASTEiJ_G0034647	protein coding gene	ChrX:29384491-29385829 (+)
CBA/J	MGP_CBAJ_G0035330	protein coding gene	ChrX:43596267-43597605 (+)
DBA/2J	MGP_DBA2J_G0035484	protein coding gene	ChrX:41159674-41161012 (+)
FVB/NJ	MGP_FVBNJ_G0035433	protein coding gene	ChrX:40924099-40925437 (+)
LP/J	MGP_LPJ_G0035572	protein coding gene	ChrX:41748327-41749665 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035471	protein coding gene	ChrX:44912890-44914228 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036199	protein coding gene	ChrX:41385643-41386981 (+)
PWK/PhJ	MGP_PWKPhJ_G0034346	protein coding gene	ChrX:28917288-28918626 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034191	protein coding gene	ChrX:30108516-30109854 (+)
WSB/EiJ	MGP_WSBEiJ_G0034791	protein coding gene	ChrX:41002968-41004306 (+)

Human Ortholog

ACTRT1, actin related protein T1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACTRT1, actin related protein T1
Synonyms

AIP1, ARIP1, ARPT1, HSD27
Links

HGNC:24027

NCBI Gene ID: 139741

neXtProt AC: NX_Q8TDG2

UniProt: Q8TDG2
Chr Location

Xq25; chrX:128050962-128052403 (-) GRCh38

MGI Vertebrate Homology

Actrt1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ACTRT1
Gene Tree

Actrt1

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

4
Find Mice (IMSR)

3 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Knock-out males show severely impaired fertility, with 60% acephalic spermatozoa and defects in sperm head-tail coupling apparatus.

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All GO Annotations

16
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

30
RefSeq

2
UniProt

1
CCDS

CCDS30102.1

Ensembl

ENSMUSG00000046615 (Evidence)
NCBI Gene

73360

			Length	Strain/Species	Flank
genomic	73360	NCBI Gene Model \| MGI Sequence Detail	1339	C57BL/6J	± kb
transcript	NM_028514	RefSeq \| MGI Sequence Detail	1339	C57BL/6
polypeptide	Q9D9J3	UniProt \| EBI \| MGI Sequence Detail	376	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000003701 actin-related protein T1

(term hierarchy)
InterPro Domains

IPR004000 Actin family

IPR043129 ATPase, nucleotide binding domain

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All nucleic 5

cDNA 5

Microarray probesets 3

Summaries

All 25

Gene Ontology 5

Phenotypes 3
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:326444 Zhang XZ, et al., Loss of perinuclear theca ACTRT1 causes acrosome detachment and severe male subfertility in mice. Development. 2022 Jun 15;149(12):dev200489

TSS for Actrt1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr160870	ChrX:45417847-45417856 (+)	-32 bp
Tssr160871	ChrX:45417860-45417872 (+)	-18 bp
Tssr160872	ChrX:45417881-45417892 (+)	3 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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