Dcbld2 MGI Mouse Gene Detail - MGI:1920629 - discoidin, CUB and LCCL domain containing 2

Symbol

Dcbld2
Name

discoidin, CUB and LCCL domain containing 2
Synonyms

1700055P21Rik, CLCP1, Esdn

Feature Type

protein coding gene
IDs

MGI:1920629
NCBI Gene: 73379
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr16:58228806-58290090 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 34.52 cM, cytoband C1.1
Mapping Data

3 experiments

SNPs within 2kb

1909 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920629	protein coding gene	Chr16:58228789-58304013 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022901	protein coding gene	Chr16:57575014-57635280 (+)
A/J	MGP_AJ_G0022868	protein coding gene	Chr16:55118515-55180147 (+)
AKR/J	MGP_AKRJ_G0022840	protein coding gene	Chr16:56843677-56909079 (+)
BALB/cJ	MGP_BALBcJ_G0022868	protein coding gene	Chr16:55212704-55272485 (+)
C3H/HeJ	MGP_C3HHeJ_G0022631	protein coding gene	Chr16:57062702-57126860 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023316	protein coding gene	Chr16:59193978-59256111 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020827	protein coding gene	Chr16:54677112-54738961 (+)
CAST/EiJ	MGP_CASTEiJ_G0022158	protein coding gene	Chr16:57396132-57458490 (+)
CBA/J	MGP_CBAJ_G0022604	protein coding gene	Chr16:61556862-61617115 (+)
DBA/2J	MGP_DBA2J_G0022736	protein coding gene	Chr16:54853514-54913431 (+)
FVB/NJ	MGP_FVBNJ_G0022711	protein coding gene	Chr16:54601617-54661569 (+)
LP/J	MGP_LPJ_G0022803	protein coding gene	Chr16:57356140-57417624 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022729	protein coding gene	Chr16:61917299-61978778 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023331	protein coding gene	Chr16:56981213-57042824 (+)
PWK/PhJ	MGP_PWKPhJ_G0021897	protein coding gene	Chr16:55153783-55214166 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021727	protein coding gene	Chr16:56758382-56816175 (+)
WSB/EiJ	MGP_WSBEiJ_G0022202	protein coding gene	Chr16:57016289-57078554 (+)

Human Ortholog

DCBLD2, discoidin, CUB and LCCL domain containing 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DCBLD2, discoidin, CUB and LCCL domain containing 2
Synonyms

CLCP1, ESDN
Links

HGNC:24627

NCBI Gene ID: 131566

neXtProt AC: NX_Q96PD2

UniProt: Q96PD2
Chr Location

3q12.1; chr3:98795941-98901695 (-) GRCh38

MGI Vertebrate Homology

Dcbld2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DCBLD2
Gene Tree

Dcbld2

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Phenotype Summary

11 phenotypes from 3 alleles in 3 genetic backgrounds
3 images
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced postnatal angiogenesis and impaired recovery from femoral artery ligation with impaired blood flow and decreased capillary density.

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All GO Annotations

11
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

755
Tissues

49
cDNA Data

12
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dcbld2

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All Sequences

62
RefSeq

16
UniProt

3
CCDS

CCDS28229.1

Ensembl

ENSMUSG00000035107 (Evidence)
NCBI Gene

73379

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035107	Ensembl Gene Model \| MGI Sequence Detail	61285	C57BL/6J	± kb
transcript	ENSMUST00000046663	Ensembl \| MGI Sequence Detail	6561	Not Applicable
polypeptide	ENSMUSP00000039915	Ensembl \| MGI Sequence Detail	769	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000029380 discoidin, CUB and LCCL domain-containing protein 2

(term hierarchy)
InterPro Domains

IPR000421 Coagulation factor 5/8 C-terminal domain

IPR000859 CUB domain

IPR008979 Galactose-binding-like domain superfamily

IPR004043 LCCL domain

IPR036609 LCCL domain superfamily

IPR050633 Neuropilin/Multicopper Oxidase/Coagulation Factor

IPR035914 Spermadhesin, CUB domain superfamily
GlyGen

Q91ZV3 6 sites, 1 N-linked glycan (3 sites)

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All nucleic 12

cDNA 12

Microarray probesets 6

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MGI:2146627

Summaries

All 41

Developmental Gene Expression 4

Gene Ontology 3

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dcbld2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138849	Chr16:58228844-58228886 (+)	59 bp
Tssr138850	Chr16:58235837-58235846 (+)	7,036 bp
Tssr138851	Chr16:58235961-58235970 (+)	7,160 bp
Tssr138852	Chr16:58256945-58256961 (+)	28,147 bp
Tssr138853	Chr16:58278686-58278727 (+)	49,901 bp
Tssr138854	Chr16:58282169-58282183 (+)	53,370 bp
Tssr138855	Chr16:58285849-58285850 (+)	57,044 bp
Tssr138856	Chr16:58286641-58286644 (+)	57,837 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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