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Hspa12a Gene Detail
Summary
  • Symbol
    Hspa12a
  • Name
    heat shock protein 12A
  • Synonyms
    1700063D12Rik, Gm19925, Hspa12a, mKIAA0417
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920692
    NCBI Gene: 73442
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:58784182-58932086 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 54.51 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4175 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920692
 protein coding gene Chr19:58784182-58932104 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025282
 protein coding gene Chr19:59284127-59349616 (-)
A/J MGP_AJ_G0025258
 protein coding gene Chr19:56385475-56452178 (-)
AKR/J MGP_AKRJ_G0025227
 protein coding gene Chr19:58146603-58212101 (-)
BALB/cJ MGP_BALBcJ_G0025253
 protein coding gene Chr19:56450239-56515916 (-)
C3H/HeJ MGP_C3HHeJ_G0025013
 protein coding gene Chr19:58397246-58464949 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025696
 protein coding gene Chr19:60717011-60787680 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023108
 protein coding gene Chr19:55258328-55334801 (-)
CAST/EiJ MGP_CASTEiJ_G0024478
 protein coding gene Chr19:58471667-58544987 (-)
CBA/J MGP_CBAJ_G0024993
 protein coding gene Chr19:63682951-63758117 (-)
DBA/2J MGP_DBA2J_G0025125
 protein coding gene Chr19:56128357-56193995 (-)
FVB/NJ MGP_FVBNJ_G0025086
 protein coding gene Chr19:55865635-55933454 (-)
LP/J MGP_LPJ_G0025211
 protein coding gene Chr19:59154273-59224633 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025119
 protein coding gene Chr19:62922230-62989920 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025754
 protein coding gene Chr19:58375359-58443612 (-)
PWK/PhJ MGP_PWKPhJ_G0024226
 protein coding gene Chr19:56133672-56200588 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024029
 protein coding gene Chr19:57042257-57115312 (-)
WSB/EiJ MGP_WSBEiJ_G0024548
 protein coding gene Chr19:58496887-58564675 (-)



Homology
more
  • Human Ortholog
    HSPA12A, heat shock protein family A (Hsp70) member 12A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSPA12A, heat shock protein family A (Hsp70) member 12A
  • Links
    NCBI Gene ID: 259217
    neXtProt AC: NX_O43301
    UniProt: O43301

  • Chr Location
    10q25.3; chr10:116671192-116850747 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout affects glucose metabolism, reducing susceptibility to diet-induced obesity. It also reduces diet-induced damage to the liver through suppression of macrophage recruitment, increases LPS-induced liver damage and increases susceptibility to ischemic brain injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    750
  • Tissues
    29
  • cDNA Data
    82
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025092 Ensembl Gene Model | MGI Sequence Detail 147905 C57BL/6J ±  kb
    transcript ENSMUST00000066285 Ensembl | MGI Sequence Detail 5734 Not Applicable  
    polypeptide ENSMUSP00000066860 Ensembl | MGI Sequence Detail 675 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000008802 heat shock 70 kDa protein 12A
      (term hierarchy)
    • InterPro Domains
      IPR043129 ATPase, nucleotide binding domain
      IPR026685 Heat shock 70kDa protein 12A, nucleotide-binding domain
    • GlyGen
      Q8K0U4 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 85
      cDNA 85

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:2147603, MGI:2147692, MGI:2147750, MGI:5012110
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 3
      Gene Ontology 2
      Phenotypes 17
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:354337 Yu W, et al., HSPA12A maintains aerobic glycolytic homeostasis and Histone3 lactylation in cardiomyocytes to attenuate myocardial ischemia/reperfusion injury. JCI Insight. 2024 Apr 8;9(7)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory