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Iws1 Gene Detail
Summary
  • Symbol
    Iws1
  • Name
    IWS1, SUPT6 interacting protein
  • Synonyms
    1700069O15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920723
    NCBI Gene: 73473
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:32200794-32237381 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 17.92 cM, cytoband B3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    821 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920723
 protein coding gene Chr18:32200377-32237384 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024223
 protein coding gene Chr18:30188671-30227767 (+)
A/J MGP_AJ_G0024189
 protein coding gene Chr18:29186439-29223576 (+)
AKR/J MGP_AKRJ_G0024158
 protein coding gene Chr18:30002531-30039813 (+)
BALB/cJ MGP_BALBcJ_G0024189
 protein coding gene Chr18:29283213-29319506 (+)
C3H/HeJ MGP_C3HHeJ_G0023957
 protein coding gene Chr18:30033424-30072964 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024631
 protein coding gene Chr18:31271509-31311963 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022072
 protein coding gene Chr18:29417840-29449155 (+)
CAST/EiJ MGP_CASTEiJ_G0023432
 protein coding gene Chr18:29937182-29974977 (+)
CBA/J MGP_CBAJ_G0023925
 protein coding gene Chr18:32222209-32263219 (+)
DBA/2J MGP_DBA2J_G0024057
 protein coding gene Chr18:28860358-28897074 (+)
FVB/NJ MGP_FVBNJ_G0024023
 protein coding gene Chr18:28565870-28602490 (+)
LP/J MGP_LPJ_G0024138
 protein coding gene Chr18:30276600-30316090 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024051
 protein coding gene Chr18:33569075-33608985 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024679
 protein coding gene Chr18:29858977-29896162 (+)
PWK/PhJ MGP_PWKPhJ_G0023175
 protein coding gene Chr18:29024919-29063789 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022984
 protein coding gene Chr18:30096147-30130587 (+)
WSB/EiJ MGP_WSBEiJ_G0023495
 protein coding gene Chr18:29763997-29802115 (+)



Homology
more
  • Human Ortholog
    IWS1, interacts with SUPT6H, CTD assembly factor 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IWS1, interacts with SUPT6H, CTD assembly factor 1
  • Links
    NCBI Gene ID: 55677
    neXtProt AC: NX_Q96ST2
    UniProt: Q96ST2

  • Chr Location
    2q14.3; chr2:127436207-127527336 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die before E3.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    776
  • Tissues
    51
  • cDNA Data
    15
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024384 Ensembl Gene Model | MGI Sequence Detail 36588 C57BL/6J ±  kb
transcript ENSMUST00000025243 Ensembl | MGI Sequence Detail 9613 Not Applicable  
polypeptide ENSMUSP00000025243 Ensembl | MGI Sequence Detail 766 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 15
    Primer pair 2
    Other 1

    Microarray probesets 8
Other
Accession IDs
less
MGI:2147358, MGI:3034394
References
more
  • Summaries
    All 37
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory