Prss59 MGI Mouse Gene Detail - MGI:1920731

Symbol

Prss59
Name

serine protease 59
Synonyms

1700074P13Rik, Tryx5

Feature Type

protein coding gene
IDs

MGI:1920731
NCBI Gene: 73481
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr6:40897371-40917491 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 18.97 cM
Mapping Data

2 experiments

SNPs within 2kb

650 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920731	protein coding gene	Chr6:40897371-40917975 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030619	protein coding gene	Chr6:39389482-39410713 (-)
A/J	MGP_AJ_G0030592	protein coding gene	Chr6:37670904-37691801 (-)
AKR/J	MGP_AKRJ_G0030519	protein coding gene	Chr6:38877514-38898404 (-)
BALB/cJ	MGP_BALBcJ_G0030602	protein coding gene	Chr6:37888202-37907717 (-)
C3H/HeJ	MGP_C3HHeJ_G0030315	protein coding gene	Chr6:38883641-38903563 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031056	protein coding gene	Chr6:40384208-40404247 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028268	protein coding gene	Chr6:35501567-35523762 (-)
CAST/EiJ	MGP_CASTEiJ_G0029717	protein coding gene	Chr6:38801733-38820791 (-)
CBA/J	MGP_CBAJ_G0030293	protein coding gene	Chr6:42013763-42033770 (-)
DBA/2J	MGP_DBA2J_G0030437	protein coding gene	Chr6:37488729-37509312 (-)
FVB/NJ	MGP_FVBNJ_G0030391	protein coding gene	Chr6:37259393-37279509 (-)
LP/J	MGP_LPJ_G0030524	protein coding gene	Chr6:39410897-39432870 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030427	protein coding gene	Chr6:44248188-44267966 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031086	protein coding gene	Chr6:38825641-38849381 (-)
PWK/PhJ	MGP_PWKPhJ_G0029431	protein coding gene	Chr6:37138770-37159521 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029267	protein coding gene	Chr6:38564852-38585446 (-)
WSB/EiJ	MGP_WSBEiJ_G0029793	protein coding gene	Chr6:38779017-38799234 (-)

Human Ortholog

PRSS59P, serine protease 59, pseudogene

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRSS59P, serine protease 59, pseudogene
Synonyms

TRY2P, Tryx5
Links

HGNC:43791

NCBI Gene ID: 207147
Chr Location

7q34; chr7:142265833-142272249 (-) GRCh38

MGI Vertebrate Homology

Prss59 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PRSS59P
Gene Tree

Prss59

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

3
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele show male infertility due to impaired sperm migration from the uterus into the oviduct.

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All GO Annotations

5
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

16

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

64
RefSeq

31
UniProt

2
CCDS

CCDS20041.1

Ensembl

ENSMUSG00000029883 (Evidence)
NCBI Gene

73481

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029883	Ensembl Gene Model \| MGI Sequence Detail	20121	C57BL/6J	± kb
transcript	ENSMUST00000122181	Ensembl \| MGI Sequence Detail	1542	Not Applicable
polypeptide	ENSMUSP00000112987	Ensembl \| MGI Sequence Detail	251	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR001314 Peptidase S1A, chymotrypsin family

IPR009003 Peptidase S1, PA clan

IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold

IPR050127 Serine Proteases (Peptidase S1 Family)

IPR001254 Serine proteases, trypsin domain

IPR018114 Serine proteases, trypsin family, histidine active site

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All nucleic 16

cDNA 16

Microarray probesets 3

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MGI:2141612, MGI:6681854

Summaries

All 25

Gene Ontology 2

Phenotypes 5
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:303285 Zhang H, et al., Male fertility in Mus musculus requires the activity of TRYX5 in sperm migration into the oviduct. J Cell Physiol. 2020 Sep;235(9):6058-6072

TSS for Prss59:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr60530	Chr6:40917904-40917911 (-)	-417 bp
Tssr60529	Chr6:40917866-40917880 (-)	-382 bp
Tssr60528	Chr6:40917461-40917488 (-)	16 bp
Tssr60527	Chr6:40906665-40906679 (-)	10,819 bp
Tssr60526	Chr6:40906646-40906650 (-)	10,843 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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