Vgll3 MGI Mouse Gene Detail - MGI:1920819 - vestigial like family member 3

Symbol

Vgll3
Name

vestigial like family member 3
Synonyms

1700110N18Rik, Vito-2

Feature Type

protein coding gene
IDs

MGI:1920819
NCBI Gene: 73569
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr16:65612143-65663254 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 37.34 cM, cytoband C1.3
Mapping Data

3 experiments

SNPs within 2kb

1692 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920819	protein coding gene	Chr16:65612075-65663254 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022946	protein coding gene	Chr16:65362840-65410599 (+)
A/J	MGP_AJ_G0022914	protein coding gene	Chr16:62540067-62589380 (+)
AKR/J	MGP_AKRJ_G0022884	protein coding gene	Chr16:64507405-64556535 (+)
BALB/cJ	MGP_BALBcJ_G0022916	protein coding gene	Chr16:62763075-62810191 (+)
C3H/HeJ	MGP_C3HHeJ_G0022678	protein coding gene	Chr16:64804039-64852379 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023364	protein coding gene	Chr16:67293353-67340587 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020867	protein coding gene	Chr16:61550718-61598444 (+)
CAST/EiJ	MGP_CASTEiJ_G0022201	protein coding gene	Chr16:65011588-65062709 (+)
CBA/J	MGP_CBAJ_G0022649	protein coding gene	Chr16:70179332-70229126 (+)
DBA/2J	MGP_DBA2J_G0022781	protein coding gene	Chr16:62297184-62353639 (+)
FVB/NJ	MGP_FVBNJ_G0022755	protein coding gene	Chr16:61909957-61958464 (+)
LP/J	MGP_LPJ_G0022850	protein coding gene	Chr16:65151038-65203263 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022774	protein coding gene	Chr16:71402053-71453733 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023380	protein coding gene	Chr16:64589276-64641879 (+)
PWK/PhJ	MGP_PWKPhJ_G0021944	protein coding gene	Chr16:62466559-62519092 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021773	protein coding gene	Chr16:64292899-64342833 (+)
WSB/EiJ	MGP_WSBEiJ_G0022248	protein coding gene	Chr16:64675110-64729452 (+)

Human Ortholog

VGLL3, vestigial like family member 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

VGLL3, vestigial like family member 3
Synonyms

VGL-3, VGL3
Links

HGNC:24327

NCBI Gene ID: 389136

neXtProt AC: NX_A8MV65

UniProt: A8MV65
Chr Location

3p12.1; chr3:86876388-86991149 (-) GRCh38

MGI Vertebrate Homology

Vgll3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: VGLL3
Gene Tree

Vgll3

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Phenotype Summary

4 phenotypes from 2 alleles in 3 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Targeted

2
Genomic Mutations

1 involving Vgll3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable and overtly normal with no apparent defects in skeletal muscle development or myoblast function. Mice from another knock-out allele show attenuated myocardial infraction-induced cardiac fibrosis and cardiac function.

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All GO Annotations

5
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

809
Tissues

81
cDNA Data

10
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase vgll3

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All Sequences

46
RefSeq

6
UniProt

3
CCDS

CCDS49884.1, CCDS88949.1

Ensembl

ENSMUSG00000091243 (Evidence)
NCBI Gene

73569

			Length	Strain/Species	Flank
genomic	ENSMUSG00000091243	Ensembl Gene Model \| MGI Sequence Detail	51112	C57BL/6J	± kb
transcript	ENSMUST00000168064	Ensembl \| MGI Sequence Detail	7009	Not Applicable
polypeptide	ENSMUSP00000131500	Ensembl \| MGI Sequence Detail	325	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000017292 transcription cofactor vestigial-like protein 3

(term hierarchy)
InterPro Domains

IPR006627 TDU repeat

IPR011520 Vestigial family
GlyGen

P85442 1 site, 1 O-linked glycan (1 site)

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All nucleic 12

cDNA 10

Primer pair 2

Microarray probesets 4

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MGI:2146708

Summaries

All 38

Developmental Gene Expression 4

Gene Ontology 4

Phenotypes 9
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Vgll3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138912	Chr16:65611953-65611973 (+)	-180 bp
Tssr138913	Chr16:65612055-65612082 (+)	-74 bp
Tssr138914	Chr16:65612084-65612154 (+)	-24 bp
Tssr138915	Chr16:65612163-65612172 (+)	25 bp
Tssr138916	Chr16:65612290-65612295 (+)	150 bp
Tssr138917	Chr16:65612394-65612408 (+)	258 bp
Tssr138918	Chr16:65612703-65612727 (+)	572 bp
Tssr138919	Chr16:65612733-65612746 (+)	597 bp
Tssr138920	Chr16:65612878-65612891 (+)	742 bp
Tssr138921	Chr16:65612909-65612924 (+)	774 bp
Tssr138922	Chr16:65615539-65615545 (+)	3,399 bp
Tssr138923	Chr16:65616629-65616631 (+)	4,487 bp
Tssr138924	Chr16:65625502-65625511 (+)	13,364 bp
Tssr138925	Chr16:65625532-65625556 (+)	13,401 bp
Tssr138926	Chr16:65636257-65636293 (+)	24,132 bp
Tssr138927	Chr16:65636693-65636697 (+)	24,552 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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