Camkmt MGI Mouse Gene Detail - MGI:1920832 - calmodulin-lysine N-methyltransferase

Symbol

Camkmt
Name

calmodulin-lysine N-methyltransferase
Synonyms

1700106N22Rik

Feature Type

protein coding gene
IDs

MGI:1920832
NCBI Gene: 73582
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr17:85397989-85766017 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 55.20 cM, cytoband E4
Mapping Data

3 experiments

SNPs within 2kb

9807 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920832	protein coding gene	Chr17:85397980-85766017 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024087	protein coding gene	Chr17:88307886-88698890 (+)
A/J	MGP_AJ_G0024046	protein coding gene	Chr17:85487373-85863067 (+)
AKR/J	MGP_AKRJ_G0024015	protein coding gene	Chr17:86893487-87261545 (+)
BALB/cJ	MGP_BALBcJ_G0024047	protein coding gene	Chr17:85337052-85706375 (+)
C3H/HeJ	MGP_C3HHeJ_G0023812	protein coding gene	Chr17:87751918-88133369 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024492	protein coding gene	Chr17:91428674-91819685 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021931	protein coding gene	Chr17:80687934-81052262 (+)
CAST/EiJ	MGP_CASTEiJ_G0023291	protein coding gene	Chr17:88545772-88933267 (+)
CBA/J	MGP_CBAJ_G0023786	protein coding gene	Chr17:95215490-95622772 (+)
DBA/2J	MGP_DBA2J_G0023914	protein coding gene	Chr17:83963484-84329147 (+)
FVB/NJ	MGP_FVBNJ_G0023880	protein coding gene	Chr17:83457415-83818885 (+)
LP/J	MGP_LPJ_G0023998	protein coding gene	Chr17:89075324-89457919 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023908	protein coding gene	Chr17:95241382-95639119 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024537	protein coding gene	Chr17:87382394-87766296 (+)
PWK/PhJ	MGP_PWKPhJ_G0023036	protein coding gene	Chr17:83548608-83922970 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022847	protein coding gene	Chr17:84206228-84580601 (+)
WSB/EiJ	MGP_WSBEiJ_G0023357	protein coding gene	Chr17:88252099-88631869 (+)

Human Ortholog

CAMKMT, calmodulin-lysine N-methyltransferase

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CAMKMT, calmodulin-lysine N-methyltransferase
Synonyms

C2orf34, Cam, CaM KMT, CLNMT, KMT
Links

HGNC:26276

NCBI Gene ID: 79823

neXtProt AC: NX_Q7Z624

UniProt: Q7Z624
Chr Location

2p21; chr2:44361947-44772592 (+) GRCh38

MGI Vertebrate Homology

Camkmt stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CAMKMT
Gene Tree

Camkmt

Diseases

1 with Camkmt mouse models

Human Disease

Mouse Models

hypotonia-cystinuria syndrome

IDs

View 2 models

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

17 phenotypes from 2 alleles in 3 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Gene trapped

22
Targeted

4
Incidental Mutations

APF
Find Mice (IMSR)

74 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced body weight, reduced muscle strength and altered somatosensory development and brain function.

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All GO Annotations

13
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

6
cDNA Data

8
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase camkmt

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All Sequences

50
RefSeq

9
UniProt

2
CCDS

CCDS37712.1

Ensembl

ENSMUSG00000071037 (Evidence)
NCBI Gene

73582

			Length	Strain/Species	Flank
genomic	73582	NCBI Gene Model \| MGI Sequence Detail	368029	C57BL/6J	± kb
transcript	NM_001364946	RefSeq \| MGI Sequence Detail	4517	C57BL/6
polypeptide	Q3U2J5	UniProt \| EBI \| MGI Sequence Detail	323	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000032391 calmodulin-lysine N-methyltransferase

(term hierarchy)
EC

2.1.1.60
InterPro Domains

IPR025800 Calmodulin-lysine N-methyltransferase

IPR019410 Lysine methyltransferase

IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily

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All nucleic 10

cDNA 8

Primer pair 2

Microarray probesets 7

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MGI:2146879, MGI:3034875

Summaries

All 40

Developmental Gene Expression 2

Diseases 1

Gene Ontology 6

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Camkmt:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr146078	Chr17:85398048-85398073 (+)	72 bp
Tssr146079	Chr17:85398075-85398149 (+)	123 bp
Tssr146080	Chr17:85497491-85497496 (+)	99,505 bp
Tssr146081	Chr17:85701244-85701246 (+)	303,256 bp
Tssr146082	Chr17:85703223-85703246 (+)	305,246 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24