Ndufaf7 MGI Mouse Gene Detail - MGI:1920944 - NADH:ubiquinone oxidoreductase complex assembly factor 7

Symbol

Ndufaf7
Name

NADH:ubiquinone oxidoreductase complex assembly factor 7
Synonyms

2410091C18Rik

Feature Type

protein coding gene
IDs

MGI:1920944
NCBI Gene: 73694
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr17:79244565-79255481 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 49.67 cM, cytoband E3
Mapping Data

4 experiments

SNPs within 2kb

482 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920944	protein coding gene	Chr17:79244535-79255481 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024047	protein coding gene	Chr17:81777113-81789748 (+)
A/J	MGP_AJ_G0024004	protein coding gene	Chr17:79276336-79287387 (+)
AKR/J	MGP_AKRJ_G0023973	protein coding gene	Chr17:80480196-80492390 (+)
BALB/cJ	MGP_BALBcJ_G0024006	protein coding gene	Chr17:79143192-79155819 (+)
C3H/HeJ	MGP_C3HHeJ_G0023770	protein coding gene	Chr17:81383186-81396056 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024450	protein coding gene	Chr17:84759427-84770374 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021892	protein coding gene	Chr17:74672717-74681424 (+)
CAST/EiJ	MGP_CASTEiJ_G0023250	protein coding gene	Chr17:81988157-81998956 (+)
CBA/J	MGP_CBAJ_G0023744	protein coding gene	Chr17:88292876-88303943 (+)
DBA/2J	MGP_DBA2J_G0023873	protein coding gene	Chr17:77791955-77803018 (+)
FVB/NJ	MGP_FVBNJ_G0023839	protein coding gene	Chr17:77311097-77322615 (+)
LP/J	MGP_LPJ_G0023956	protein coding gene	Chr17:82632582-82645362 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023867	protein coding gene	Chr17:88412291-88425208 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024495	protein coding gene	Chr17:80955497-80968489 (+)
PWK/PhJ	MGP_PWKPhJ_G0022996	protein coding gene	Chr17:77289538-77300710 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022807	protein coding gene	Chr17:77741413-77753336 (+)
WSB/EiJ	MGP_WSBEiJ_G0023317	protein coding gene	Chr17:81772669-81786184 (+)

Human Ortholog

NDUFAF7, NADH:ubiquinone oxidoreductase complex assembly factor 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NDUFAF7, NADH:ubiquinone oxidoreductase complex assembly factor 7
Synonyms

C2orf56, MidA, PRO1853
Links

HGNC:28816

NCBI Gene ID: 55471

neXtProt AC: NX_Q7L592

UniProt: Q7L592
Chr Location

2p22.2; chr2:37231631-37271365 (+) GRCh38

MGI Vertebrate Homology

Ndufaf7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NDUFAF7
Gene Tree

Ndufaf7

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Gene trapped

2
Targeted

2
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

23 strains or lines available

Embryos homozygous for a gene trap mutation die prenatally.

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All GO Annotations

25
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

54
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ndufaf7

ZFIN ndufaf7

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All Sequences

55
RefSeq

5
UniProt

5
CCDS

CCDS28982.1

Ensembl

ENSMUSG00000024082 (Evidence)
NCBI Gene

73694

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024082	Ensembl Gene Model \| MGI Sequence Detail	10917	C57BL/6J	± kb
transcript	ENSMUST00000024887	Ensembl \| MGI Sequence Detail	1749	Not Applicable
polypeptide	ENSMUSP00000024887	Ensembl \| MGI Sequence Detail	436	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000038859 protein arginine methyltransferase NDUFAF7, mitochondrial

(term hierarchy)
EC

2.1.1.320
InterPro Domains

IPR003788 Protein arginine methyltransferase NDUFAF7

IPR038375 Protein arginine methyltransferase NDUFAF7 superfamily

IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
GlyGen

Q9CWG8 1 site, 1 O-linked glycan (1 site)

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All nucleic 55

cDNA 55

Microarray probesets 1

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MGI:2142108

Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 5
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:214316 Zurita Rendon O, et al., The arginine methyltransferase NDUFAF7 is essential for complex I assembly and early vertebrate embryogenesis. Hum Mol Genet. 2014 Oct 1;23(19):5159-70

TSS for Ndufaf7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr145912	Chr17:79244553-79244612 (+)	18 bp
Tssr145913	Chr17:79244639-79244650 (+)	80 bp
Tssr5209	Chr17:79244666-79244673 (+)	105 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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