Mcmbp MGI Mouse Gene Detail - MGI:1920977 - minichromosome maintenance complex binding protein

Symbol

Mcmbp
Name

minichromosome maintenance complex binding protein
Synonyms

1110007A13Rik, MGC:36596

Feature Type

protein coding gene
IDs

MGI:1920977
NCBI Gene: 210711
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr7:128298165-128342153 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 70.41 cM
Mapping Data

2 experiments

SNPs within 2kb

1027 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920977	protein coding gene	Chr7:128298165-128342219 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033086	protein coding gene	Chr7:133133609-133176887 (-)
A/J	MGP_AJ_G0033068	protein coding gene	Chr7:129561386-129606876 (-)
AKR/J	MGP_AKRJ_G0033000	protein coding gene	Chr7:132952309-132997862 (-)
BALB/cJ	MGP_BALBcJ_G0033069	protein coding gene	Chr7:129215421-129261289 (-)
C3H/HeJ	MGP_C3HHeJ_G0032783	protein coding gene	Chr7:132831517-132876944 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033579	protein coding gene	Chr7:138317447-138366177 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030551	protein coding gene	Chr7:130723433-130765351 (-)
CAST/EiJ	MGP_CASTEiJ_G0032113	protein coding gene	Chr7:124626628-124671579 (-)
CBA/J	MGP_CBAJ_G0032756	protein coding gene	Chr7:143069607-143116657 (-)
DBA/2J	MGP_DBA2J_G0032908	protein coding gene	Chr7:127537255-127581625 (-)
FVB/NJ	MGP_FVBNJ_G0032861	protein coding gene	Chr7:127401863-127445867 (-)
LP/J	MGP_LPJ_G0033002	protein coding gene	Chr7:134607154-134650451 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032893	protein coding gene	Chr7:144075222-144123808 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033598	protein coding gene	Chr7:131908647-131953483 (-)
PWK/PhJ	MGP_PWKPhJ_G0031819	protein coding gene	Chr7:120555347-120599197 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031665	protein coding gene	Chr7:118718405-118762949 (-)
WSB/EiJ	MGP_WSBEiJ_G0032224	protein coding gene	Chr7:132887779-132936153 (-)

Human Ortholog

MCMBP, minichromosome maintenance complex binding protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MCMBP, minichromosome maintenance complex binding protein
Synonyms

C10orf119, MCM-BP
Links

HGNC:25782

NCBI Gene ID: 79892

neXtProt AC: NX_Q9BTE3

UniProt: Q9BTE3
Chr Location

10q26.11; chr10:119829404-119892556 (-) GRCh38

MGI Vertebrate Homology

Mcmbp stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MCMBP
Gene Tree

Mcmbp

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

80
Endonuclease-mediated

3
Gene trapped

77
Incidental Mutations

APF
Find Mice (IMSR)

83 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

16
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

10
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mcmbp

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All Sequences

48
RefSeq

2
UniProt

2
CCDS

CCDS40153.1

Ensembl

ENSMUSG00000048170 (Evidence)
NCBI Gene

210711

			Length	Strain/Species	Flank
genomic	210711	NCBI Gene Model \| MGI Sequence Detail	43989	C57BL/6J	± kb
transcript	NM_145955	RefSeq \| MGI Sequence Detail	4171	C57BL/6
polypeptide	Q8R3C0	UniProt \| EBI \| MGI Sequence Detail	642	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000031398 mini-chromosome maintenance complex-binding protein

(term hierarchy)
InterPro Domains

IPR019140 Mini-chromosome maintenance complex-binding protein
GlyGen

Q8R3C0 1 site, 1 O-linked glycan (1 site)

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All nucleic 10

cDNA 10

Microarray probesets 6

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MGI:2142122, MGI:2384809

Summaries

All 35

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 9
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mcmbp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr75126	Chr7:128342195-128342249 (-)	-69 bp
Tssr75125	Chr7:128342158-128342194 (-)	-23 bp
Tssr75124	Chr7:128342136-128342147 (-)	11 bp
Tssr75123	Chr7:128342121-128342134 (-)	25 bp
Tssr75122	Chr7:128341356-128341361 (-)	794 bp
Tssr75121	Chr7:128319184-128319190 (-)	22,966 bp
Tssr75120	Chr7:128299306-128299310 (-)	42,845 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24