Lce1l Gene Detail

Summary

• Symbol
  Lce1l
• Name
  late cornified envelope 1L
• Synonyms
  1110008K04Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1920980
  NCBI Gene: 73730
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr3:92757256-92758593 bp, - strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 3, 40.14 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  118 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920980	protein coding gene	Chr3:92757256-92758593 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027520	protein coding gene	Chr3:93312067-93313404 (-)
A/J	MGP_AJ_G0027487	protein coding gene	Chr3:90376544-90378002 (-)
AKR/J	MGP_AKRJ_G0027452	protein coding gene	Chr3:92496131-92497468 (-)
BALB/cJ	MGP_BALBcJ_G0027495	protein coding gene	Chr3:90186024-90187361 (-)
C3H/HeJ	MGP_C3HHeJ_G0027233	protein coding gene	Chr3:92710471-92711808 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027937	protein coding gene	Chr3:96864321-96865658 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025286	protein coding gene	Chr3:87002034-87003383 (-)
CAST/EiJ	MGP_CASTEiJ_G0026680	protein coding gene	Chr3:92137318-92138655 (-)
CBA/J	MGP_CBAJ_G0027209	protein coding gene	Chr3:100181869-100183206 (-)
DBA/2J	MGP_DBA2J_G0027346	protein coding gene	Chr3:89703561-89704898 (-)
FVB/NJ	MGP_FVBNJ_G0027314	protein coding gene	Chr3:87866116-87867453 (-)
LP/J	MGP_LPJ_G0027454	protein coding gene	Chr3:94532527-94533864 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027340	protein coding gene	Chr3:106484662-106485999 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027997	protein coding gene	Chr3:92227320-92228657 (-)
PWK/PhJ	MGP_PWKPhJ_G0026411	protein coding gene	Chr3:89582652-89583989 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026232	protein coding gene	Chr3:90564404-90565701 (-)
WSB/EiJ	MGP_WSBEiJ_G0026763	protein coding gene	Chr3:92598711-92600048 (-)

Homology

• Human Ortholog
  LCE1A, late cornified envelope 1A

• Vertebrate Orthologs
  5

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  LCE1A, late cornified envelope 1A
  
• Synonyms
  LEP1
• Links
  HGNC:29459

  NCBI Gene ID: 353131

  neXtProt AC: NX_Q5T7P2

  UniProt: Q5T7P2

  
  
• Chr Location
  1q21.3; chr1:152827473-152828097 (+)  GRCh38

---

• Human Ortholog
  LCE1B, late cornified envelope 1B
  
• Synonyms
  LEP2, SPRL2A
• Links
  HGNC:16611

  NCBI Gene ID: 353132

  neXtProt AC: NX_Q5T7P3

  UniProt: Q5T7P3

  
  
• Chr Location
  1q21.3

---

• Human Ortholog
  LCE1C, late cornified envelope 1C
  
• Synonyms
  LEP3
• Links
  HGNC:29464

  NCBI Gene ID: 353133

  neXtProt AC: NX_Q5T751

  UniProt: Q5T751

  
  
• Chr Location
  1q21.3; chr1:152804832-152806651 (-)  GRCh38

---

• Human Ortholog
  LCE1E, late cornified envelope 1E
  
• Synonyms
  LEP5
• Links
  HGNC:29466

  NCBI Gene ID: 353135

  neXtProt AC: NX_Q5T753

  UniProt: Q5T753

  
  
• Chr Location
  1q21.3; chr1:152786214-152788426 (+)  GRCh38

---

• Human Ortholog
  LCE1F, late cornified envelope 1F
  
• Synonyms
  LEP6
• Links
  HGNC:29467

  NCBI Gene ID: 353137

  neXtProt AC: NX_Q5T754

  UniProt: Q5T754

  
  
• Chr Location
  1q21.3; chr1:152775140-152777024 (+)  GRCh38

---

• MGI Vertebrate Homology
  Lce1l stringent orthology
  5 human;1 mouse
  
• HCOP
  vertebrate homology predictions: LCE1A, LCE1B, LCE1C, LCE1E, LCE1F
• Gene Tree
  Lce1l
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  7 phenotype references
  

• All Mutations and Alleles
  5
• Chemically induced (other)
  1
• Endonuclease-mediated
  2
• Radiation induced
  1
• Targeted
  1
• Genomic Mutations
  2 involving Lce1l
• Find Mice (IMSR)
  12 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  3
• GO References
  1

Expression

• Assay Results
  706
• cDNA Data
  3
• Literature Summary
  2

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  28
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS38518.1

• Ensembl
  ENSMUSG00000046676 (Evidence)
• NCBI Gene
  73730

Representative Sequences			Length	Strain/Species
genomic	73730	NCBI Gene Model | MGI Sequence Detail	1338	C57BL/6J
transcript	NM_028628	RefSeq | MGI Sequence Detail	670	C57BL/6
polypeptide	NP_082904	RefSeq | MGI Sequence Detail	135	C57BL/6

Protein
Information

• UniProt
  1 Sequence

Molecular
Reagents

• All nucleic 3

  cDNA 3

  
  

  Microarray probesets 3

Other
Accession IDs

MGI:2139699

References

• Summaries
  All 25

  Developmental Gene Expression 2

  Diseases 1

  Gene Ontology 1

  Phenotypes 7
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:341642 Schwartz B, et al., ZNF750 Regulates Skin Barrier Function by Driving Cornified Envelope and Lipid Processing Pathways. J Invest Dermatol. 2023 Sep 3;

TSS for Lce1l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr34337	Chr3:92758591-92758593 (-)	1 bp