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Kprp Gene Detail
Summary
  • Symbol
    Kprp
  • Name
    keratinocyte expressed, proline-rich
  • Synonyms
    1110001M24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920981
    NCBI Gene: 433619
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:92730381-92734554 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 40.14 cM, cytoband F2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    157 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920981
 protein coding gene Chr3:92730381-92734554 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027519
 protein coding gene Chr3:93284921-93289136 (-)
A/J MGP_AJ_G0027486
 protein coding gene Chr3:90349465-90353680 (-)
AKR/J MGP_AKRJ_G0027451
 protein coding gene Chr3:92469271-92473444 (-)
BALB/cJ MGP_BALBcJ_G0027494
 protein coding gene Chr3:90159108-90163323 (-)
C3H/HeJ MGP_C3HHeJ_G0027232
 protein coding gene Chr3:92683522-92687737 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027936
 protein coding gene Chr3:96837448-96841621 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025285
 protein coding gene Chr3:86974545-86978757 (-)
CAST/EiJ MGP_CASTEiJ_G0026679
 protein coding gene Chr3:92109307-92113527 (-)
CBA/J MGP_CBAJ_G0027208
 protein coding gene Chr3:100154905-100159120 (-)
DBA/2J MGP_DBA2J_G0027345
 protein coding gene Chr3:89676133-89680306 (-)
FVB/NJ MGP_FVBNJ_G0027313
 protein coding gene Chr3:87839241-87843414 (-)
LP/J MGP_LPJ_G0027453
 protein coding gene Chr3:94505574-94509789 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027339
 protein coding gene Chr3:106457559-106461773 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027996
 protein coding gene Chr3:92199036-92203251 (-)
PWK/PhJ MGP_PWKPhJ_G0026410
 protein coding gene Chr3:89554380-89558593 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026231
 protein coding gene Chr3:90535291-90539620 (-)
WSB/EiJ MGP_WSBEiJ_G0026762
 protein coding gene Chr3:92571239-92575453 (-)



Homology
more
  • Human Ortholog
    KPRP, keratinocyte proline rich protein
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KPRP, keratinocyte proline rich protein
  • Synonyms
    C1orf45
  • Links
    NCBI Gene ID: 448834
    neXtProt AC: NX_Q5T749
    UniProt: Q5T749

  • Chr Location
    1q21.3; chr1:152758025-152762056 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for a null allele show a thin stratum granulosum, detachment of lower layers of the stratum corneum, abnormal desmosome structure and enhanced percutaneous immune responses to irritants and allergens. Homozygotes show a similar phenotype as heterozygotes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 433619 NCBI Gene Model | MGI Sequence Detail 4174 C57BL/6J ±  kb
    transcript NM_028629 RefSeq | MGI Sequence Detail 2738 C57BL/6  
    polypeptide B2RUR4 UniProt | EBI | MGI Sequence Detail 657 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139600
    References
    more
    • Summaries
      All 32
      Diseases 1
      Gene Ontology 1
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory