About   Help   FAQ
Man2c1 Gene Detail
Summary
  • Symbol
    Man2c1
  • Name
    mannosidase, alpha, class 2C, member 1
  • Synonyms
    1110025H24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920994
    NCBI Gene: 73744
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:57037953-57049497 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 30.89 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    255 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920994
 protein coding gene Chr9:57037953-57050006 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034859
 protein coding gene Chr9:56299750-56311712 (+)
A/J MGP_AJ_G0034840
 protein coding gene Chr9:54487729-54500385 (+)
AKR/J MGP_AKRJ_G0034769
 protein coding gene Chr9:55744801-55758473 (+)
BALB/cJ MGP_BALBcJ_G0034832
 protein coding gene Chr9:54289759-54302084 (+)
C3H/HeJ MGP_C3HHeJ_G0034542
 protein coding gene Chr9:56218401-56231316 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035351
 protein coding gene Chr9:57889528-57901513 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032262
 protein coding gene Chr9:53827106-53839286 (+)
CAST/EiJ MGP_CASTEiJ_G0033863
 protein coding gene Chr9:56300167-56312165 (+)
CBA/J MGP_CBAJ_G0034513
 protein coding gene Chr9:59908380-59922451 (+)
DBA/2J MGP_DBA2J_G0034672
 protein coding gene Chr9:54369343-54381324 (+)
FVB/NJ MGP_FVBNJ_G0034614
 protein coding gene Chr9:53591520-53603861 (+)
LP/J MGP_LPJ_G0034755
 protein coding gene Chr9:56593358-56605343 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034657
 protein coding gene Chr9:61378861-61399014 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035373
 protein coding gene Chr9:55760739-55774517 (+)
PWK/PhJ MGP_PWKPhJ_G0033568
 protein coding gene Chr9:54398568-54411041 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033402
 protein coding gene Chr9:56053545-56066279 (+)
WSB/EiJ MGP_WSBEiJ_G0033976
 protein coding gene Chr9:55698190-55711852 (+)



Homology
more
  • Human Ortholog
    MAN2C1, mannosidase alpha class 2C member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAN2C1, mannosidase alpha class 2C member 1
  • Synonyms
    CDDG2, MAN6A8, MANA, MANA1
  • Links
    NCBI Gene ID: 4123
    neXtProt AC: NX_Q9NTJ4
    UniProt: Q9NTJ4

  • Chr Location
    15q24.2; chr15:75355207-75368612 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Germ line null mutants display neuronal and glia degeneration, glycogen accumulation, and liver and kidney damage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 73744 NCBI Gene Model | MGI Sequence Detail 11545 C57BL/6J ±  kb
    transcript NM_028636 RefSeq | MGI Sequence Detail 3221 C57BL/6  
    polypeptide Q91W89 UniProt | EBI | MGI Sequence Detail 1039 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      17 Sequences
    • Protein Ontology
      PR:000010109 alpha-mannosidase 2C1
      (term hierarchy)
    • EC
      3.2.1.24
    • InterPro Domains
      IPR011013 Galactose mutarotase-like domain superfamily
      IPR027291 Glycoside hydrolase 38, N-terminal domain superfamily
      IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel
      IPR028995 Glycoside hydrolase families 57/38, central domain superfamily
      IPR015341 Glycoside hydrolase family 38, central domain
      IPR037094 Glycoside hydrolase family 38, central domain superfamily
      IPR000602 Glycoside hydrolase family 38, N-terminal domain
      IPR011682 Glycosyl hydrolase family 38, C-terminal
      IPR041147 Glycosyl hydrolases family 38, C-terminal beta sandwich domain
    • GlyGen
      Q91W89 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 4
    References
    more
    • Summaries
      All 29
      Gene Ontology 7
      Phenotypes 3
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:205550 Paciotti S, et al., Accumulation of free oligosaccharides and tissue damage in cytosolic alpha-mannosidase (Man2c1)-deficient mice. J Biol Chem. 2014 Apr 4;289(14):9611-22
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory