Kif2c MGI Mouse Gene Detail - MGI:1921054

Symbol

Kif2c
Name

kinesin family member 2C
Synonyms

4930402F02Rik, MGC:11883

Feature Type

protein coding gene
IDs

MGI:1921054
NCBI Gene: 73804
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr4:117016830-117039821 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 53.42 cM, cytoband D1
Mapping Data

4 experiments

SNPs within 2kb

653 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921054	protein coding gene	Chr4:117016830-117039836 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028647	protein coding gene	Chr4:118122969-118147351 (-)
A/J	MGP_AJ_G0028608	protein coding gene	Chr4:113569632-113594325 (-)
AKR/J	MGP_AKRJ_G0028558	protein coding gene	Chr4:116050923-116073597 (-)
BALB/cJ	MGP_BALBcJ_G0028629	protein coding gene	Chr4:114199750-114222708 (-)
C3H/HeJ	MGP_C3HHeJ_G0028343	protein coding gene	Chr4:117616519-117640829 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029070	protein coding gene	Chr4:122684434-122712407 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026354	protein coding gene	Chr4:107611893-107634451 (-)
CAST/EiJ	MGP_CASTEiJ_G0027777	protein coding gene	Chr4:114834139-114858135 (-)
CBA/J	MGP_CBAJ_G0028310	protein coding gene	Chr4:126038045-126064237 (-)
DBA/2J	MGP_DBA2J_G0028458	protein coding gene	Chr4:114205891-114229066 (-)
FVB/NJ	MGP_FVBNJ_G0028426	protein coding gene	Chr4:112706051-112729404 (-)
LP/J	MGP_LPJ_G0028560	protein coding gene	Chr4:118303526-118329227 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028453	protein coding gene	Chr4:130985291-131015869 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029107	protein coding gene	Chr4:117199166-117224848 (-)
PWK/PhJ	MGP_PWKPhJ_G0027503	protein coding gene	Chr4:111004165-111029259 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027326	protein coding gene	Chr4:113497329-113519580 (-)
WSB/EiJ	MGP_WSBEiJ_G0027856	protein coding gene	Chr4:117070146-117105854 (-)

Human Ortholog

KIF2C, kinesin family member 2C

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KIF2C, kinesin family member 2C
Synonyms

CT139, KNSL6, MCAK
Links

HGNC:6393

NCBI Gene ID: 11004

neXtProt AC: NX_Q99661

UniProt: Q99661
Chr Location

1p34.1; chr1:44739818-44767767 (+) GRCh38

MGI Vertebrate Homology

Kif2c stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KIF2C
Gene Tree

Kif2c

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Phenotype Summary

17 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

24
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

15
Radiation induced

1
Targeted

5
Genomic Mutations

4 involving Kif2c
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a conditional allele activated in nerve cells exhibit reduced mushroom spine density, increased AMPAR-mediated EPSCs with increased surface AMPAR receptors, reduced freezing in response to context or tone conditioned stimulus, reduced investigation of a novel stranger, and impaired spartial working memory.

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All GO Annotations

48
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1279
Tissues

91
cDNA Data

12
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kif2c

ZFIN kif2c

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All Sequences

68
RefSeq

18
UniProt

5
CCDS

CCDS18531.1, CCDS71452.1

Ensembl

ENSMUSG00000028678 (Evidence)
NCBI Gene

73804

			Length	Strain/Species	Flank
genomic	73804	NCBI Gene Model \| MGI Sequence Detail	22992	C57BL/6J	± kb
transcript	NM_134471	RefSeq \| MGI Sequence Detail	2840	ZRU/MplStud
polypeptide	Q922S8	UniProt \| EBI \| MGI Sequence Detail	721	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000009310 kinesin-like protein KIF2C

(term hierarchy)
PDB

1V8J, 1V8K, 3EDL, 5XJA, 5XJB
InterPro Domains

IPR027640 Kinesin-like protein

IPR001752 Kinesin motor domain

IPR019821 Kinesin motor domain, conserved site

IPR036961 Kinesin motor domain superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 14

cDNA 13

Other 1

Microarray probesets 6

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MGD-MRK-28119, MGI:104825

Summaries

All 56

Developmental Gene Expression 5

Gene Ontology 9

Phenotypes 17
Earliest

J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Kif2c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr42967	Chr4:117040146-117040148 (-)	-326 bp
Tssr42966	Chr4:117039820-117039833 (-)	-6 bp
Tssr42965	Chr4:117039734-117039800 (-)	54 bp
Tssr42964	Chr4:117035955-117035976 (-)	3,855 bp
Tssr42963	Chr4:117035923-117035951 (-)	3,884 bp
Tssr42962	Chr4:117035910-117035915 (-)	3,908 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24