Ppp1r21 MGI Mouse Gene Detail - MGI:1921075 - protein phosphatase 1, regulatory subunit 21

Symbol

Ppp1r21
Name

protein phosphatase 1, regulatory subunit 21
Synonyms

1110018J12Rik, Ccdc128, Klraq1

Feature Type

protein coding gene
IDs

MGI:1921075
NCBI Gene: 73825
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr17:88837552-88895795 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 58.02 cM
Mapping Data

2 experiments

SNPs within 2kb

2362 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921075	protein coding gene	Chr17:88837546-88895795 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024110	protein coding gene	Chr17:92024067-92084749 (+)
A/J	MGP_AJ_G0024070	protein coding gene	Chr17:89051329-89112691 (+)
AKR/J	MGP_AKRJ_G0024039	protein coding gene	Chr17:90545048-90602650 (+)
BALB/cJ	MGP_BALBcJ_G0024071	protein coding gene	Chr17:88880559-88938624 (+)
C3H/HeJ	MGP_C3HHeJ_G0023836	protein coding gene	Chr17:91438489-91496406 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024516	protein coding gene	Chr17:95225257-95288647 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021954	protein coding gene	Chr17:84111679-84171443 (+)
CAST/EiJ	MGP_CASTEiJ_G0023315	protein coding gene	Chr17:92303572-92364421 (+)
CBA/J	MGP_CBAJ_G0023809	protein coding gene	Chr17:99249489-99311074 (+)
DBA/2J	MGP_DBA2J_G0023938	protein coding gene	Chr17:87438584-87496356 (+)
FVB/NJ	MGP_FVBNJ_G0023904	protein coding gene	Chr17:86972242-87029589 (+)
LP/J	MGP_LPJ_G0024022	protein coding gene	Chr17:92820539-92881046 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023932	protein coding gene	Chr17:99037049-99097304 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024561	protein coding gene	Chr17:91088036-91150347 (+)
PWK/PhJ	MGP_PWKPhJ_G0023060	protein coding gene	Chr17:87135196-87196468 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022871	protein coding gene	Chr17:87826548-87888617 (+)
WSB/EiJ	MGP_WSBEiJ_G0023381	protein coding gene	Chr17:91944463-92008389 (+)

Human Ortholog

PPP1R21, protein phosphatase 1 regulatory subunit 21

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPP1R21, protein phosphatase 1 regulatory subunit 21
Synonyms

CCDC128, FERRY2, Fy-2, KLRAQ1, NEDHFBA
Links

HGNC:30595

NCBI Gene ID: 129285

neXtProt AC: NX_Q6ZMI0

UniProt: Q6ZMI0
Chr Location

2p16.3; chr2:48440598-48515391 (+) GRCh38

MGI Vertebrate Homology

Ppp1r21 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PPP1R21
Gene Tree

Ppp1r21

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Endonuclease-mediated

3
Gene trapped

16
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

53 strains or lines available

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All GO Annotations

5
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

791
Tissues

12
cDNA Data

10
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ppp1r21

ZFIN ppp1r21

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All Sequences

46
RefSeq

4
UniProt

1
CCDS

CCDS29023.1

Ensembl

ENSMUSG00000034709 (Evidence)
NCBI Gene

73825

			Length	Strain/Species	Flank
genomic	73825	NCBI Gene Model \| MGI Sequence Detail	58244	C57BL/6J	± kb
transcript	NM_028658	RefSeq \| MGI Sequence Detail	3151	C57BL/6
polypeptide	Q3TDD9	UniProt \| EBI \| MGI Sequence Detail	780	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000029691 protein phosphatase 1 regulatory subunit 21

(term hierarchy)
InterPro Domains

IPR040024 Protein phosphatase 1 regulatory subunit 21

IPR049372 Protein phosphatase 1 regulatory subunit 21, C-terminal

IPR019343 Protein phosphatase 1 regulatory subunit 21, N-terminal

IPR019348 Protein phosphatase 1 regulatory subunit 21, six-helix bundle
GlyGen

Q3TDD9 1 site, 1 N-linked glycan (1 site)

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All nucleic 10

cDNA 10

Microarray probesets 3

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MGI:2146849, MGI:2147082

Summaries

All 34

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ppp1r21:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr146233	Chr17:88837541-88837570 (+)	4 bp
Tssr146234	Chr17:88837577-88837589 (+)	31 bp
Tssr146235	Chr17:88837639-88837662 (+)	99 bp
Tssr146236	Chr17:88837680-88837701 (+)	139 bp
Tssr146237	Chr17:88837716-88837725 (+)	169 bp
Tssr146238	Chr17:88887801-88887817 (+)	50,257 bp
Tssr146239	Chr17:88887823-88887835 (+)	50,277 bp
Tssr146240	Chr17:88889387-88889402 (+)	51,843 bp
Tssr5230	Chr17:88891110-88891153 (+)	53,580 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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