Poldip3 MGI Mouse Gene Detail - MGI:1921076 - polymerase (DNA-directed), delta interacting protein 3

Symbol

Poldip3
Name

polymerase (DNA-directed), delta interacting protein 3
Synonyms

1110008P04Rik, PDIP46

Feature Type

protein coding gene
IDs

MGI:1921076
NCBI Gene: 73826
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr15:83010177-83033585 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 39.40 cM
Mapping Data

2 experiments

SNPs within 2kb

579 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921076	protein coding gene	Chr15:83010169-83033585 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022159	protein coding gene	Chr15:83789505-83815606 (-)
A/J	MGP_AJ_G0022118	protein coding gene	Chr15:80740190-80763568 (-)
AKR/J	MGP_AKRJ_G0022093	protein coding gene	Chr15:83052603-83078678 (-)
BALB/cJ	MGP_BALBcJ_G0022124	protein coding gene	Chr15:80882689-80907285 (-)
C3H/HeJ	MGP_C3HHeJ_G0021894	protein coding gene	Chr15:83049391-83074164 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022569	protein coding gene	Chr15:87026976-87052204 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020093	protein coding gene	Chr15:77125603-77150052 (-)
CAST/EiJ	MGP_CASTEiJ_G0021416	protein coding gene	Chr15:83793232-83964969 (-)
CBA/J	MGP_CBAJ_G0021861	protein coding gene	Chr15:89769446-89798898 (-)
DBA/2J	MGP_DBA2J_G0021988	protein coding gene	Chr15:80232798-80256047 (-)
FVB/NJ	MGP_FVBNJ_G0021967	protein coding gene	Chr15:79268927-79292235 (-)
LP/J	MGP_LPJ_G0022059	protein coding gene	Chr15:83964443-83987782 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021987	protein coding gene	Chr15:94696928-94724855 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022584	protein coding gene	Chr15:83091341-83120182 (-)
PWK/PhJ	MGP_PWKPhJ_G0021157	protein coding gene	Chr15:80208577-80229355 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020991	protein coding gene	Chr15:82811413-82838036 (-)
WSB/EiJ	MGP_WSBEiJ_G0021465	protein coding gene	Chr15:83585591-83608870 (-)

Human Ortholog

POLDIP3, DNA polymerase delta interacting protein 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

POLDIP3, DNA polymerase delta interacting protein 3
Synonyms

PDIP3, PDIP46, SKAR
Links

HGNC:23782

NCBI Gene ID: 84271

neXtProt AC: NX_Q9BY77

UniProt: Q9BY77
Chr Location

22q13.2; chr22:42583721-42614962 (-) GRCh38

MGI Vertebrate Homology

Poldip3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: POLDIP3
Gene Tree

Poldip3

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References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

14
Radiation induced

2
Targeted

2
Genomic Mutations

3 involving Poldip3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

15
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

739
Tissues

28
cDNA Data

191
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase poldip3

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All Sequences

79
RefSeq

4
UniProt

7
CCDS

CCDS27697.1, CCDS84183.1

Ensembl

ENSMUSG00000041815 (Evidence)
NCBI Gene

73826

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041815	Ensembl Gene Model \| MGI Sequence Detail	23409	C57BL/6J	± kb
transcript	ENSMUST00000058793	Ensembl \| MGI Sequence Detail	3299	Not Applicable
polypeptide	ENSMUSP00000054548	Ensembl \| MGI Sequence Detail	420	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000012968 polymerase delta-interacting protein 3

(term hierarchy)
InterPro Domains

IPR051229 ALYREF mRNA export adapter

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR034784 PDIP3, RNA recognition motif

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

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All nucleic 194

Genomic 1

cDNA 192

Primer pair 1

Microarray probesets 4

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MGI:2145896, MGI:2146111, MGI:2146279

Summaries

All 61

Developmental Gene Expression 3

Diseases 1

Gene Ontology 6

Phenotypes 28
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:285676 Suzuki A, et al., Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis. Mech Dev. 2018 Apr;150:21-27

TSS for Poldip3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135628	Chr15:83033558-83033565 (-)	23 bp
Tssr135627	Chr15:83033508-83033551 (-)	55 bp
Tssr135626	Chr15:83033471-83033505 (-)	97 bp
Tssr135625	Chr15:83033224-83033257 (-)	344 bp
Tssr135624	Chr15:83022383-83022416 (-)	11,185 bp
Tssr135623	Chr15:83017480-83017512 (-)	16,089 bp
Tssr135622	Chr15:83012196-83012209 (-)	21,382 bp
Tssr135621	Chr15:83011793-83011841 (-)	21,768 bp
Tssr135620	Chr15:83011663-83011691 (-)	21,908 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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