Dcaf4 Gene Detail

Summary

• Symbol
  Dcaf4
• Name
  DDB1 and CUL4 associated factor 4
• Synonyms
  1110018E21Rik, Wdr21

• Feature Type
  protein coding gene
• IDs
  MGI:1921078
  NCBI Gene: 73828
• Alliance
  gene page
• Transcription Start Sites
  5 TSS

Location &
Maps

• Sequence Map
  Chr12:83567240-83588694 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 12, 38.75 cM, cytoband D3
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  787 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921078	protein coding gene	Chr12:83567145-83588768 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019913	protein coding gene	Chr12:84158319-84182640 (+)
A/J	MGP_AJ_G0019870	protein coding gene	Chr12:80971612-80993671 (+)
AKR/J	MGP_AKRJ_G0019846	protein coding gene	Chr12:83161631-83183022 (+)
BALB/cJ	MGP_BALBcJ_G0019850	protein coding gene	Chr12:81322371-81345186 (+)
C3H/HeJ	MGP_C3HHeJ_G0019656	protein coding gene	Chr12:83630432-83652910 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020302	protein coding gene	Chr12:86557043-86581555 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017919	protein coding gene	Chr12:77899948-77921876 (+)
CAST/EiJ	MGP_CASTEiJ_G0019205	protein coding gene	Chr12:78567879-78591852 (+)
CBA/J	MGP_CBAJ_G0019627	protein coding gene	Chr12:89899040-89926591 (+)
DBA/2J	MGP_DBA2J_G0019742	protein coding gene	Chr12:80523435-80544527 (+)
FVB/NJ	MGP_FVBNJ_G0019728	protein coding gene	Chr12:79464368-79486842 (+)
LP/J	MGP_LPJ_G0019814	protein coding gene	Chr12:84032772-84055814 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019767	protein coding gene	Chr12:92870026-92896287 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020336	protein coding gene	Chr12:82757730-82780644 (+)
PWK/PhJ	MGP_PWKPhJ_G0018969	protein coding gene	Chr12:74996106-75019094 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018764	protein coding gene	Chr12:77219408-77242189 (+)
WSB/EiJ	MGP_WSBEiJ_G0019257	protein coding gene	Chr12:83418047-83444777 (+)

Homology

• Human Ortholog
  DCAF4, DDB1 and CUL4 associated factor 4

• Vertebrate Orthologs
  5

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  DCAF4, DDB1 and CUL4 associated factor 4
  
• Synonyms
  WDR21, WDR21A
• Links
  HGNC:20229

  NCBI Gene ID: 26094

  neXtProt AC: NX_Q8WV16

  UniProt: Q8WV16

  
  
• Chr Location
  14q24.2; chr14:72926377-72962098 (+)  GRCh38

---

• Human Ortholog
  DCAF4L1, DDB1 and CUL4 associated factor 4 like 1
  
• Synonyms
  WDR21B
• Links
  HGNC:27723

  NCBI Gene ID: 285429

  neXtProt AC: NX_Q3SXM0

  UniProt: Q3SXM0

  
  
• Chr Location
  4p13; chr4:41981756-41986465 (+)  GRCh38

---

• Human Ortholog
  DCAF4L2, DDB1 and CUL4 associated factor 4 like 2
  
• Synonyms
  WDR21C
• Links
  HGNC:26657

  NCBI Gene ID: 138009

  neXtProt AC: NX_Q8NA75

  UniProt: Q8NA75

  
  
• Chr Location
  8q21.3; chr8:87870747-87874015 (-)  GRCh38

---

• MGI Vertebrate Homology
  Dcaf4 stringent orthology
  3 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: DCAF4, DCAF4L1, DCAF4L2
• Gene Tree
  Dcaf4
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  13 phenotype references
  

• All Mutations and Alleles
  74
• Chemically induced (other)
  1
• Endonuclease-mediated
  2
• Gene trapped
  68
• Targeted
  3
• Genomic Mutations
  1 involving Dcaf4
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  41 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  2
• GO References
  2

Expression

• Assay Results
  768
• Tissues
  10
• cDNA Data
  77
• Literature Summary
  1

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase dcaf4

Sequences &
Gene Models

• All Sequences
  72
• RefSeq
  22
• UniProt
  3
• CCDS
  CCDS26027.1, CCDS88367.1

• Ensembl
  ENSMUSG00000021222 (Evidence)
• NCBI Gene
  73828

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000021222	Ensembl Gene Model | MGI Sequence Detail	21455	C57BL/6J
transcript	ENSMUST00000223291	Ensembl | MGI Sequence Detail	2005	Not Applicable
polypeptide	ENSMUSP00000152717	Ensembl | MGI Sequence Detail	532	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• InterPro Domains
  IPR052254 CUL4-DDB1 E3 ligase complex substrate receptor
  IPR001680 WD40 repeat
  IPR036322 WD40-repeat-containing domain superfamily
  IPR015943 WD40/YVTN repeat-like-containing domain superfamily

Molecular
Reagents

• All nucleic 77

  cDNA 77

  
  

  Microarray probesets 2

References

• Summaries
  All 31

  Developmental Gene Expression 1

  Gene Ontology 2

  Phenotypes 13
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dcaf4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114255	Chr12:83567210-83567221 (+)	-24 bp
Tssr114256	Chr12:83567241-83567258 (+)	10 bp
Tssr114257	Chr12:83567278-83567291 (+)	45 bp
Tssr114258	Chr12:83567302-83567372 (+)	97 bp
Tssr114259	Chr12:83572817-83572843 (+)	5,590 bp