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Zdbf2 Gene Detail
Summary
  • Symbol
    Zdbf2
  • Name
    zinc finger, DBF-type containing 2
  • Synonyms
    4930431J08Rik, 9330107J05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921134
    NCBI Gene: 73884
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:63312424-63353735 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 32.31 cM, cytoband C2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    618 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921134
 protein coding gene Chr1:63239517-63353735 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016088
 protein coding gene Chr1:63421315-63444294 (+)
A/J MGP_AJ_G0016071
 protein coding gene Chr1:61175697-61219702 (+)
AKR/J MGP_AKRJ_G0016028
 protein coding gene Chr1:62862393-62910295 (+)
BALB/cJ MGP_BALBcJ_G0016026
 protein coding gene Chr1:61262105-61303738 (+)
C3H/HeJ MGP_C3HHeJ_G0015858
 protein coding gene Chr1:63136013-63188253 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016479
 protein coding gene Chr1:65861407-65909433 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014200
 protein coding gene Chr1:57289560-57330443 (+)
CAST/EiJ MGP_CASTEiJ_G0015441
 protein coding gene Chr1:62405934-62450807 (+)
CBA/J MGP_CBAJ_G0015830
 protein coding gene Chr1:67964352-68016808 (+)
DBA/2J MGP_DBA2J_G0015931
 protein coding gene Chr1:60589409-60636699 (+)
FVB/NJ MGP_FVBNJ_G0015934
 protein coding gene Chr1:59884135-59925073 (+)
LP/J MGP_LPJ_G0016003
 protein coding gene Chr1:64307126-64349063 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015954
 protein coding gene Chr1:70881944-70939896 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016526
 protein coding gene Chr1:62844766-62888386 (+)
PWK/PhJ MGP_PWKPhJ_G0015228
 protein coding gene Chr1:59959188-59996107 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015007
 protein coding gene Chr1:62362991-62411316 (+)
WSB/EiJ MGP_WSBEiJ_G0015503
 protein coding gene Chr1:62571861-62615466 (+)



Homology
more
  • Human Ortholog
    ZDBF2, zinc finger DBF-type containing 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZDBF2, zinc finger DBF-type containing 2
  • Synonyms
    Slx9
  • Links
    NCBI Gene ID: 57683
    neXtProt AC: NX_Q9HCK1
    UniProt: Q9HCK1

  • Chr Location
    2q33.3; chr2:206274663-206314427 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a modified isoform encoding allele exhibit impaired methylation of the somatic differentially methylated region of the gene and decreased body weight and size when inherited paternally.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1083
  • Tissues
    110
  • cDNA Data
    42
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027520 Ensembl Gene Model | MGI Sequence Detail 41312 C57BL/6J ±  kb
    transcript ENSMUST00000239483 Ensembl | MGI Sequence Detail 12523 Not Applicable  
    polypeptide ENSMUSP00000159296 Ensembl | MGI Sequence Detail 2498 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000017609 DBF4-type zinc finger-containing protein 2
      (term hierarchy)
    • InterPro Domains
      IPR038890 DBF4-type zinc finger-containing protein 2
      IPR038545 DBF-type zinc finger superfamily
      IPR006572 Zinc finger, DBF-type
    • GlyGen
      Q5SS00 4 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 1
      cDNA 42
      Primer pair 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2442330
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 9
      Gene Ontology 2
      Phenotypes 14
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory