Psmb11 MGI Mouse Gene Detail - MGI:1921152 - proteasome (prosome, macropain) subunit, beta type, 11

Symbol

Psmb11
Name

proteasome (prosome, macropain) subunit, beta type, 11
Synonyms

5830406J20Rik, beta5t

Feature Type

protein coding gene
IDs

MGI:1921152
NCBI Gene: 73902
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr14:54862767-54867013 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 27.87 cM
Mapping Data

1 experiment

SNPs within 2kb

206 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921152	protein coding gene	Chr14:54858890-54867013 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021317	protein coding gene	Chr14:48590028-48595845 (+)
A/J	MGP_AJ_G0021276	protein coding gene	Chr14:47637999-47642160 (+)
AKR/J	MGP_AKRJ_G0021252	protein coding gene	Chr14:49361471-49365632 (+)
BALB/cJ	MGP_BALBcJ_G0021280	protein coding gene	Chr14:47612467-47616628 (+)
C3H/HeJ	MGP_C3HHeJ_G0021060	protein coding gene	Chr14:49054723-49059066 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021718	protein coding gene	Chr14:51052242-51056495 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019263	protein coding gene	Chr14:46053317-46057846 (+)
CAST/EiJ	MGP_CASTEiJ_G0020579	protein coding gene	Chr14:45294110-45298319 (+)
CBA/J	MGP_CBAJ_G0021027	protein coding gene	Chr14:52563769-52567930 (+)
DBA/2J	MGP_DBA2J_G0021148	protein coding gene	Chr14:47377524-47381703 (+)
FVB/NJ	MGP_FVBNJ_G0021130	protein coding gene	Chr14:46831371-46835532 (+)
LP/J	MGP_LPJ_G0021222	protein coding gene	Chr14:49593744-49597905 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021154	protein coding gene	Chr14:51985809-51989970 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021745	protein coding gene	Chr14:48549240-48553401 (+)
PWK/PhJ	MGP_PWKPhJ_G0020325	protein coding gene	Chr14:43907774-43912114 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020153	protein coding gene	Chr14:44531234-44535894 (+)
WSB/EiJ	MGP_WSBEiJ_G0020632	protein coding gene	Chr14:48836359-48840522 (+)

Human Ortholog

PSMB11, proteasome subunit beta 11

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PSMB11, proteasome subunit beta 11
Synonyms

BETA5T
Links

HGNC:31963

NCBI Gene ID: 122706

neXtProt AC: NX_A5LHX3

UniProt: A5LHX3
Chr Location

14q11.2; chr14:23042212-23044060 (+) GRCh38

MGI Vertebrate Homology

Psmb11 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PSMB11
Gene Tree

Psmb11

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Phenotype Summary

27 phenotypes from 3 alleles in 3 genetic backgrounds
3 phenotypes from multigenic genotypes
34 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

1
Spontaneous

1
Targeted

7
Genomic Mutations

1 involving Psmb11
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a gene trapped allele have fewer CD8+ single positive cells.

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All GO Annotations

15
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

711
Tissues

2
cDNA Data

13
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

37
RefSeq

2
UniProt

1
CCDS

CCDS49491.1

Ensembl

ENSMUSG00000072423 (Evidence)
NCBI Gene

73902

			Length	Strain/Species	Flank
genomic	73902	NCBI Gene Model \| MGI Sequence Detail	4247	C57BL/6J	± kb
transcript	NM_175204	RefSeq \| MGI Sequence Detail	4247	C57BL/6
polypeptide	Q8BG41	UniProt \| EBI \| MGI Sequence Detail	302	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000013371 proteasome subunit beta type-11

(term hierarchy)
EC

3.4.25.1
InterPro Domains

IPR029055 Nucleophile aminohydrolases, N-terminal

IPR000243 Peptidase T1A, proteasome beta-subunit

IPR016050 Proteasome beta-type subunit, conserved site

IPR023333 Proteasome B-type subunit

IPR001353 Proteasome, subunit alpha/beta

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All nucleic 14

cDNA 13

Primer pair 1

Microarray probesets 3

Summaries

All 64

Developmental Gene Expression 10

Gene Ontology 6

Phenotypes 34
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:352089 Grammer C, et al., Vhl safeguards thymic epithelial cell identity and thymopoietic capacity by constraining Hif1a activity during development. iScience. 2024 Jul 19;27(7):110258

TSS for Psmb11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125663	Chr14:54862762-54862774 (+)	1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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