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Irak3 Gene Detail
Summary
  • Symbol
    Irak3
  • Name
    interleukin-1 receptor-associated kinase 3
  • Synonyms
    4833428C18Rik, IRAK-M
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921164
    NCBI Gene: 73914
  • Alliance
    gene page
  • Transcription Start Sites
    32 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:119977553-120038035 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 67.94 cM, cytoband D2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2059 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921164
 protein coding gene Chr10:119977553-120038035 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017772
 protein coding gene Chr10:123277621-123345483 (-)
A/J MGP_AJ_G0017747
 protein coding gene Chr10:118407832-118466478 (-)
AKR/J MGP_AKRJ_G0017710
 protein coding gene Chr10:121937652-121999724 (-)
BALB/cJ MGP_BALBcJ_G0017711
 protein coding gene Chr10:118795313-118854768 (-)
C3H/HeJ MGP_C3HHeJ_G0017535
 protein coding gene Chr10:122142743-122204767 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018166
 protein coding gene Chr10:127457736-127525403 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015847
 protein coding gene Chr10:112772102-112823756 (-)
CAST/EiJ MGP_CASTEiJ_G0017096
 protein coding gene Chr10:122452210-122512454 (-)
CBA/J MGP_CBAJ_G0017504
 protein coding gene Chr10:132649158-132722006 (-)
DBA/2J MGP_DBA2J_G0017610
 protein coding gene Chr10:117540492-117601682 (-)
FVB/NJ MGP_FVBNJ_G0017605
 protein coding gene Chr10:116531749-116592628 (-)
LP/J MGP_LPJ_G0017684
 protein coding gene Chr10:123833843-123897330 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017634
 protein coding gene Chr10:135269498-135337713 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018207
 protein coding gene Chr10:121942438-122006528 (-)
PWK/PhJ MGP_PWKPhJ_G0016880
 protein coding gene Chr10:117638730-117699306 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016671
 protein coding gene Chr10:120838127-120895748 (-)
WSB/EiJ MGP_WSBEiJ_G0017156
 protein coding gene Chr10:122184925-122249792 (-)



Homology
more
  • Human Ortholog
    IRAK3, interleukin 1 receptor associated kinase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IRAK3, interleukin 1 receptor associated kinase 3
  • Synonyms
    ASRT5, IRAKM
  • Links
    NCBI Gene ID: 11213
    neXtProt AC: NX_Q9Y616
    UniProt: Q9Y616

  • Chr Location
    12q14.3; chr12:66189195-66254622 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Irak3 mouse models; 1 with human IRAK3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display abnormal inflammatory responses to bacterial infections and loose bone mass with age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    64
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 73914 NCBI Gene Model | MGI Sequence Detail 60483 C57BL/6J ±  kb
    transcript NR_152856 RefSeq | MGI Sequence Detail 3087 C57BL/6  
    polypeptide Q8K4B2 UniProt | EBI | MGI Sequence Detail 609 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 24

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143647
    References
    more
    • Summaries
      All 97
      Diseases 2
      Gene Ontology 11
      Phenotypes 49
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:353318 Tunali G, et al., IL-1 receptor-associated kinase-3 acts as an immune checkpoint in myeloid cells to limit cancer immunotherapy. J Clin Invest. 2023 Apr 3;133(7)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory