Herc3 MGI Mouse Gene Detail - MGI:1921248

Symbol

Herc3
Name

hect domain and RLD 3
Synonyms

5730409F18Rik, MGC:30404

Feature Type

protein coding gene
IDs

MGI:1921248
NCBI Gene: 73998
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr6:58808450-58897383 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 27.82 cM
Mapping Data

2 experiments

SNPs within 2kb

2111 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921248	protein coding gene	Chr6:58808440-58897383 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030818	protein coding gene	Chr6:58454218-58551976 (+)
A/J	MGP_AJ_G0030785	protein coding gene	Chr6:55928509-56021210 (+)
AKR/J	MGP_AKRJ_G0030713	protein coding gene	Chr6:57773988-57862349 (+)
BALB/cJ	MGP_BALBcJ_G0030797	protein coding gene	Chr6:56216012-56311207 (+)
C3H/HeJ	MGP_C3HHeJ_G0030511	protein coding gene	Chr6:57750778-57841298 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031255	protein coding gene	Chr6:59734575-59839889 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028447	protein coding gene	Chr6:52940396-53031443 (+)
CAST/EiJ	MGP_CASTEiJ_G0029909	protein coding gene	Chr6:57403358-57498910 (+)
CBA/J	MGP_CBAJ_G0030484	protein coding gene	Chr6:62246444-62340993 (+)
DBA/2J	MGP_DBA2J_G0030635	protein coding gene	Chr6:55632409-55728362 (+)
FVB/NJ	MGP_FVBNJ_G0030588	protein coding gene	Chr6:55183194-55271987 (+)
LP/J	MGP_LPJ_G0030720	protein coding gene	Chr6:58386528-58479893 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030623	protein coding gene	Chr6:64904869-64996194 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031281	protein coding gene	Chr6:57626626-57726611 (+)
PWK/PhJ	MGP_PWKPhJ_G0029624	protein coding gene	Chr6:55384658-55474686 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029451	protein coding gene	Chr6:56837842-56931338 (+)
WSB/EiJ	MGP_WSBEiJ_G0029990	protein coding gene	Chr6:57824807-57918261 (+)

Human Ortholog

HERC3, HECT and RLD domain containing E3 ubiquitin protein ligase 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HERC3, HECT and RLD domain containing E3 ubiquitin protein ligase 3
Links

HGNC:4876

NCBI Gene ID: 8916

neXtProt AC: NX_Q15034

UniProt: Q15034
Chr Location

4q22.1; chr4:88523810-88708541 (+) GRCh38

MGI Vertebrate Homology

Herc3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HERC3
Gene Tree

Herc3

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Phenotype Summary

6 phenotypes from 1 allele in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (ENU)

1
Endonuclease-mediated

5
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

65 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit abnormal hair follicle bulge morphology.

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All GO Annotations

4
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

836
Tissues

40
cDNA Data

80
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase herc3

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All Sequences

88
RefSeq

30
UniProt

9
CCDS

CCDS20196.1, CCDS90054.1

Ensembl

ENSMUSG00000029804 (Evidence)
NCBI Gene

73998

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029804	Ensembl Gene Model \| MGI Sequence Detail	88934	C57BL/6J	± kb
transcript	ENSMUST00000041401	Ensembl \| MGI Sequence Detail	4731	Not Applicable
polypeptide	ENSMUSP00000040025	Ensembl \| MGI Sequence Detail	1050	Not Applicable

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UniProt

9 Sequences
InterPro Domains

IPR000569 HECT domain

IPR035983 HECT, E3 ligase catalytic domain

IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II

IPR000408 Regulator of chromosome condensation, RCC1

IPR051210 Ubiquitin ligases and GEF domain-containing protein

IPR051709 Ubiquitin ligases and GTPase regulators

IPR044611 Ubiquitin-protein ligase E3A/B/C-like
GlyGen

A6H6S0 1 site, 1 N-linked glycan (1 site)

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All nucleic 80

cDNA 80

Microarray probesets 3

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MGI:2141458

Summaries

All 32

Developmental Gene Expression 3

Gene Ontology 1

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:353423 Zegeye Y, et al., E3 ubiquitin ligase Herc3 deficiency leads to accumulation of subretinal microglia and retinal neurodegeneration. Sci Rep. 2024 Feb 6;14(1):3010

TSS for Herc3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr56746	Chr6:58808441-58808489 (+)	15 bp
Tssr56747	Chr6:58808498-58808514 (+)	56 bp
Tssr56748	Chr6:58808536-58808551 (+)	94 bp
Tssr56749	Chr6:58808865-58808883 (+)	424 bp
Tssr56750	Chr6:58810674-58810719 (+)	2,247 bp
Tssr56751	Chr6:58839864-58839895 (+)	31,430 bp
Tssr56752	Chr6:58839949-58839961 (+)	31,505 bp
Tssr56753	Chr6:58883529-58883564 (+)	75,097 bp
Tssr56754	Chr6:58886160-58886164 (+)	77,712 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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