Msl1 MGI Mouse Gene Detail - MGI:1921276

Symbol

Msl1
Name

male specific lethal 1
Synonyms

2810017F12Rik, 4121402D02Rik, 4930463F05Rik

Feature Type

protein coding gene
IDs

MGI:1921276
NCBI Gene: 74026
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr11:98686342-98698685 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 62.67 cM, cytoband D
Mapping Data

3 experiments

SNPs within 2kb

280 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921276	protein coding gene	Chr11:98684214-98698685 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019073	protein coding gene	Chr11:101399658-101413599 (+)
A/J	MGP_AJ_G0019041	protein coding gene	Chr11:97152549-97164896 (+)
AKR/J	MGP_AKRJ_G0019011	protein coding gene	Chr11:100161796-100174128 (+)
BALB/cJ	MGP_BALBcJ_G0019015	protein coding gene	Chr11:97648869-97661224 (+)
C3H/HeJ	MGP_C3HHeJ_G0018828	protein coding gene	Chr11:100306098-100321390 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019466	protein coding gene	Chr11:104501880-104514208 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017098	protein coding gene	Chr11:94711797-94724099 (+)
CAST/EiJ	MGP_CASTEiJ_G0018382	protein coding gene	Chr11:101272057-101306368 (+)
CBA/J	MGP_CBAJ_G0018799	protein coding gene	Chr11:108856299-108868652 (+)
DBA/2J	MGP_DBA2J_G0018907	protein coding gene	Chr11:96710849-96723139 (+)
FVB/NJ	MGP_FVBNJ_G0018896	protein coding gene	Chr11:96225932-96238303 (+)
LP/J	MGP_LPJ_G0018977	protein coding gene	Chr11:101860898-101873286 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018923	protein coding gene	Chr11:108565992-108578317 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019506	protein coding gene	Chr11:100512469-100526478 (+)
PWK/PhJ	MGP_PWKPhJ_G0018153	protein coding gene	Chr11:97752885-97765310 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017942	protein coding gene	Chr11:100254565-100267756 (+)
WSB/EiJ	MGP_WSBEiJ_G0018431	protein coding gene	Chr11:100468027-100482435 (+)

Human Ortholog

MSL1, MSL complex subunit 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MSL1, MSL complex subunit 1
Synonyms

MSL-1
Links

HGNC:27905

NCBI Gene ID: 339287

neXtProt AC: NX_Q68DK7

UniProt: Q68DK7
Chr Location

17q21.1; chr17:40121971-40136917 (+) GRCh38

MGI Vertebrate Homology

Msl1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MSL1
Gene Tree

Msl1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

2
Gene trapped

4
Targeted

3
Genomic Mutations

1 involving Msl1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

16 strains or lines available

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All GO Annotations

21
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

5
cDNA Data

155
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase msl1

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All Sequences

69
RefSeq

11
UniProt

2
CCDS

CCDS25364.1, CCDS88248.1, CCDS88249.1, CCDS88250.1

Ensembl

ENSMUSG00000052915 (Evidence)
NCBI Gene

74026

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052915	Ensembl Gene Model \| MGI Sequence Detail	12344	C57BL/6J	± kb
transcript	ENSMUST00000037915	Ensembl \| MGI Sequence Detail	4593	Not Applicable
polypeptide	ENSMUSP00000042792	Ensembl \| MGI Sequence Detail	616	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010673 male-specific lethal 1

(term hierarchy)
PDB

2Y0M, 2Y0N
InterPro Domains

IPR029332 PEHE domain

IPR026711 Protein male-specific lethal-1

IPR031840 Protein male-specific lethal-1, dimerisation domain
GlyGen

Q6PDM1 1 site, 1 O-linked glycan (1 site)

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All nucleic 156

cDNA 155

Primer pair 1

Microarray probesets 9

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MGI:1922153, MGI:1923804, MGI:2144043

Summaries

All 49

Developmental Gene Expression 4

Gene Ontology 10

Phenotypes 13
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Msl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104789	Chr11:98685997-98686035 (+)	-326 bp
Tssr104790	Chr11:98686063-98686080 (+)	-270 bp
Tssr104791	Chr11:98686295-98686309 (+)	-40 bp
Tssr104792	Chr11:98686321-98686400 (+)	19 bp
Tssr104793	Chr11:98686647-98686666 (+)	315 bp
Tssr104794	Chr11:98689432-98689439 (+)	3,094 bp
Tssr104795	Chr11:98689479-98689490 (+)	3,143 bp
Tssr104796	Chr11:98689500-98689501 (+)	3,159 bp
Tssr104797	Chr11:98689528-98689537 (+)	3,191 bp
Tssr104798	Chr11:98690026-98690041 (+)	3,692 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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