Acot6 MGI Mouse Gene Detail - MGI:1921287

Symbol

Acot6
Name

acyl-CoA thioesterase 6
Synonyms

4632408A20Rik

Feature Type

protein coding gene
IDs

MGI:1921287
NCBI Gene: 217700
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr12:84147538-84158128 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 39.04 cM
Mapping Data

3 experiments

SNPs within 2kb

388 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921287	protein coding gene	Chr12:84147428-84158128 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019927	protein coding gene	Chr12:84782690-84793366 (+)
A/J	MGP_AJ_G0019884	protein coding gene	Chr12:81577594-81588296 (+)
AKR/J	MGP_AKRJ_G0019860	protein coding gene	Chr12:83783436-83794381 (+)
BALB/cJ	MGP_BALBcJ_G0019864	protein coding gene	Chr12:81906002-81916870 (+)
C3H/HeJ	MGP_C3HHeJ_G0019670	protein coding gene	Chr12:84255993-84266680 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020315	protein coding gene	Chr12:87223498-87235555 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017933	protein coding gene	Chr12:78485555-78496440 (+)
CAST/EiJ	MGP_CASTEiJ_G0019219	protein coding gene	Chr12:79194314-79204891 (+)
CBA/J	MGP_CBAJ_G0019641	protein coding gene	Chr12:90580911-90594233 (+)
DBA/2J	MGP_DBA2J_G0019756	protein coding gene	Chr12:81108996-81119682 (+)
FVB/NJ	MGP_FVBNJ_G0019742	protein coding gene	Chr12:80065475-80076189 (+)
LP/J	MGP_LPJ_G0019828	protein coding gene	Chr12:84660219-84673416 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019781	protein coding gene	Chr12:93523522-93534817 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020349	protein coding gene	Chr12:83387752-83398445 (+)
PWK/PhJ	MGP_PWKPhJ_G0018983	protein coding gene	Chr12:75592084-75603901 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018778	protein coding gene	Chr12:77862373-77872949 (+)
WSB/EiJ	MGP_WSBEiJ_G0019271	protein coding gene	Chr12:84050194-84061660 (+)

Human Ortholog

ACOT6, acyl-CoA thioesterase 6

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACOT6, acyl-CoA thioesterase 6
Synonyms

c14_5530, C14orf42
Links

HGNC:33159

NCBI Gene ID: 641372

neXtProt AC: NX_Q3I5F7

UniProt: Q3I5F7
Chr Location

14q24.3; chr14:73610945-73619888 (+) GRCh38

MGI Vertebrate Homology

Acot6 stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: ACOT6
Protein SuperFamily

Acyl-CoA_hydro
Gene Tree

Acot6

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
7 phenotype references

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

2
Genomic Mutations

1 involving Acot6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available

Mice homozygous for a knock-out allele exhibit no detectable phenotypic abnormalities.

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All GO Annotations

10
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

927
Tissues

36
cDNA Data

22
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

40
RefSeq

4
UniProt

2
CCDS

CCDS26038.1

Ensembl

ENSMUSG00000043487 (Evidence)
NCBI Gene

217700

			Length	Strain/Species	Flank
genomic	217700	NCBI Gene Model \| MGI Sequence Detail	10591	C57BL/6J	± kb
transcript	NM_172580	RefSeq \| MGI Sequence Detail	3283	C57BL/6
polypeptide	Q32Q92	UniProt \| EBI \| MGI Sequence Detail	419	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000030698 acyl-coenzyme A thioesterase 6

(term hierarchy)
EC

3.1.2.-
InterPro Domains

IPR016662 Acyl-CoA thioesterase, long chain

IPR042490 Acyl-CoA thioester hydrolase/BAAT, N-terminal

IPR006862 Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase

IPR029058 Alpha/Beta hydrolase fold

IPR014940 BAAT/Acyl-CoA thioester hydrolase C-terminal

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All nucleic 22

cDNA 22

Microarray probesets 3

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MGI:3034709

Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Acot6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114317	Chr12:84147514-84147565 (+)	2 bp
Tssr114318	Chr12:84147571-84147589 (+)	42 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24