Nfam1 MGI Mouse Gene Detail - MGI:1921289 - Nfat activating molecule with ITAM motif 1

Symbol

Nfam1
Name

Nfat activating molecule with ITAM motif 1
Synonyms

4921501M20Rik, Nfam1

Feature Type

protein coding gene
IDs

MGI:1921289
NCBI Gene: 74039
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr15:82880937-82917598 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 39.01 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

1055 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921289	protein coding gene	Chr15:82877174-82917598 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022156	protein coding gene	Chr15:83644896-83688355 (-)
A/J	MGP_AJ_G0022115	protein coding gene	Chr15:80598787-80636814 (-)
AKR/J	MGP_AKRJ_G0022090	protein coding gene	Chr15:82914290-82950954 (-)
BALB/cJ	MGP_BALBcJ_G0022121	protein coding gene	Chr15:80741488-80776952 (-)
C3H/HeJ	MGP_C3HHeJ_G0021891	protein coding gene	Chr15:82915894-82951869 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022566	protein coding gene	Chr15:86874159-86912940 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020090	protein coding gene	Chr15:76996584-77031730 (-)
CAST/EiJ	MGP_CASTEiJ_G0021413	protein coding gene	Chr15:83648942-83684709 (-)
CBA/J	MGP_CBAJ_G0021858	protein coding gene	Chr15:89626663-89667292 (-)
DBA/2J	MGP_DBA2J_G0021985	protein coding gene	Chr15:80099870-80138298 (-)
FVB/NJ	MGP_FVBNJ_G0021964	protein coding gene	Chr15:79134589-79171094 (-)
LP/J	MGP_LPJ_G0022056	protein coding gene	Chr15:83811576-83851641 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021984	protein coding gene	Chr15:94550770-94590463 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022581	protein coding gene	Chr15:82942925-82981875 (-)
PWK/PhJ	MGP_PWKPhJ_G0021154	protein coding gene	Chr15:80072247-80112023 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020988	protein coding gene	Chr15:82661417-82698752 (-)
WSB/EiJ	MGP_WSBEiJ_G0021462	protein coding gene	Chr15:83445293-83480204 (-)

Human Ortholog

NFAM1, NFAT activating protein with ITAM motif 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NFAM1, NFAT activating protein with ITAM motif 1
Synonyms

CNAIP
Links

HGNC:29872

NCBI Gene ID: 150372

neXtProt AC: NX_Q8NET5

UniProt: Q8NET5
Chr Location

22q13.2; chr22:42380407-42437986 (-) GRCh38

MGI Vertebrate Homology

Nfam1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NFAM1
Gene Tree

Nfam1

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References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

9
Radiation induced

2
Targeted

2
Genomic Mutations

3 involving Nfam1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

22
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

32
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

76
RefSeq

10
UniProt

9
CCDS

CCDS27694.1, CCDS70651.1, CCDS70652.1

Ensembl

ENSMUSG00000058099 (Evidence)
NCBI Gene

74039

			Length	Strain/Species	Flank
genomic	74039	NCBI Gene Model \| MGI Sequence Detail	36662	C57BL/6J	± kb
transcript	NM_001271411	RefSeq \| MGI Sequence Detail	3962	C57BL/6
polypeptide	Q8R4V1	UniProt \| EBI \| MGI Sequence Detail	264	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000011161 NFAT activation molecule 1

(term hierarchy)
InterPro Domains

IPR033549 NFAT activation molecule 1
GlyGen

Q8R4V1 2 sites

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All nucleic 34

Genomic 2

cDNA 32

Microarray probesets 4

Summaries

All 54

Developmental Gene Expression 1

Diseases 1

Gene Ontology 6

Phenotypes 29
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nfam1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135615	Chr15:82917495-82917513 (-)	94 bp
Tssr135614	Chr15:82917453-82917475 (-)	134 bp
Tssr135613	Chr15:82917430-82917441 (-)	162 bp
Tssr135612	Chr15:82915308-82915312 (-)	2,288 bp
Tssr135611	Chr15:82915147-82915159 (-)	2,445 bp
Tssr135610	Chr15:82889165-82889193 (-)	28,419 bp
Tssr135609	Chr15:82883255-82883289 (-)	34,326 bp
Tssr135608	Chr15:82883189-82883224 (-)	34,391 bp
Tssr135607	Chr15:82883132-82883154 (-)	34,455 bp
Tssr135606	Chr15:82883117-82883131 (-)	34,474 bp
Tssr135605	Chr15:82882775-82882811 (-)	34,805 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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