Steap2 MGI Mouse Gene Detail - MGI:1921301 - six transmembrane epithelial antigen of prostate 2

Symbol

Steap2
Name

six transmembrane epithelial antigen of prostate 2
Synonyms

4921538B17Rik

Feature Type

protein coding gene
IDs

MGI:1921301
NCBI Gene: 74051
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr5:5714829-5744578 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 3.18 cM
Mapping Data

2 experiments

SNPs within 2kb

776 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921301	protein coding gene	Chr5:5714829-5744649 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029275	protein coding gene	Chr5:2571979-2602249 (-)
A/J	MGP_AJ_G0029238	protein coding gene	Chr5:2467054-2497879 (-)
AKR/J	MGP_AKRJ_G0029188	protein coding gene	Chr5:2517207-2548015 (-)
BALB/cJ	MGP_BALBcJ_G0029256	protein coding gene	Chr5:2681714-2712090 (-)
C3H/HeJ	MGP_C3HHeJ_G0028976	protein coding gene	Chr5:2719497-2759007 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029706	protein coding gene	Chr5:2957856-2989043 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026949	protein coding gene	Chr5:2539347-2569250 (-)
CAST/EiJ	MGP_CASTEiJ_G0028389	protein coding gene	Chr5:2668523-2699272 (-)
CBA/J	MGP_CBAJ_G0028937	protein coding gene	Chr5:2946685-2983774 (-)
DBA/2J	MGP_DBA2J_G0029090	protein coding gene	Chr5:2617304-2650600 (-)
FVB/NJ	MGP_FVBNJ_G0029051	protein coding gene	Chr5:2463949-2493908 (-)
LP/J	MGP_LPJ_G0029179	protein coding gene	Chr5:2668330-2699137 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029078	protein coding gene	Chr5:2883426-2914444 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029737	protein coding gene	Chr5:2566255-2601307 (-)
PWK/PhJ	MGP_PWKPhJ_G0028111	protein coding gene	Chr5:2544268-2575085 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027944	protein coding gene	Chr5:2861290-2891830 (-)
WSB/EiJ	MGP_WSBEiJ_G0028469	protein coding gene	Chr5:2606029-2637327 (-)

Human Ortholog

STEAP2, STEAP2 metalloreductase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STEAP2, STEAP2 metalloreductase
Synonyms

IPCA1, PCANAP1, PUMPCn, STAMP1, STMP
Links

HGNC:17885

NCBI Gene ID: 261729

neXtProt AC: NX_Q8NFT2

UniProt: Q8NFT2
Chr Location

7q21.13; chr7:90167590-90243408 (+) GRCh38

MGI Vertebrate Homology

Steap2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: STEAP2
Gene Tree

Steap2

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

38
Endonuclease-mediated

1
Gene trapped

33
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

61 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

33
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

804
Tissues

83
cDNA Data

42
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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All Sequences

85
RefSeq

16
UniProt

5
CCDS

CCDS39007.1, CCDS71541.1

Ensembl

ENSMUSG00000015653 (Evidence)
NCBI Gene

74051

			Length	Strain/Species	Flank
genomic	ENSMUSG00000015653	Ensembl Gene Model \| MGI Sequence Detail	29750	C57BL/6J	± kb
transcript	ENSMUST00000115426	Ensembl \| MGI Sequence Detail	10408	Not Applicable
polypeptide	ENSMUSP00000111086	Ensembl \| MGI Sequence Detail	489	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000015731 metalloreductase STEAP2

(term hierarchy)
EC

1.16.1.-
InterPro Domains

IPR013130 Ferric reductase transmembrane component-like domain

IPR036291 NAD(P)-binding domain superfamily

IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal

IPR051267 STEAP family metalloreductases

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All nucleic 42

cDNA 42

Microarray probesets 8

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MGI:2141006, MGI:2141126

Summaries

All 43

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Steap2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr50069	Chr5:5744559-5744581 (-)	8 bp
Tssr50068	Chr5:5744499-5744539 (-)	59 bp
Tssr50067	Chr5:5744480-5744491 (-)	92 bp
Tssr50066	Chr5:5744436-5744447 (-)	136 bp
Tssr50065	Chr5:5744269-5744312 (-)	287 bp
Tssr50064	Chr5:5744024-5744109 (-)	511 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24