About   Help   FAQ
Ttc21a Gene Detail
Summary
  • Symbol
    Ttc21a
  • Name
    tetratricopeptide repeat domain 21A
  • Synonyms
    4921538N17Rik, Thm2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921302
    NCBI Gene: 74052
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:119766672-119796859 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 71.33 cM, cytoband F4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    895 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921302
 protein coding gene Chr9:119766656-119798496 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035427
 protein coding gene Chr9:122747241-122777476 (+)
A/J MGP_AJ_G0035408
 protein coding gene Chr9:118150416-118180566 (+)
AKR/J MGP_AKRJ_G0035340
 protein coding gene Chr9:121244864-121274830 (+)
BALB/cJ MGP_BALBcJ_G0035403
 protein coding gene Chr9:118038659-118068533 (+)
C3H/HeJ MGP_C3HHeJ_G0035111
 protein coding gene Chr9:121713976-121743928 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035926
 protein coding gene Chr9:126110530-126140682 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032809
 protein coding gene Chr9:115356309-115388633 (+)
CAST/EiJ MGP_CASTEiJ_G0034416
 protein coding gene Chr9:121720055-121752700 (+)
CBA/J MGP_CBAJ_G0035078
 protein coding gene Chr9:130814937-130845070 (+)
DBA/2J MGP_DBA2J_G0035237
 protein coding gene Chr9:117602275-117632219 (+)
FVB/NJ MGP_FVBNJ_G0035184
 protein coding gene Chr9:116480228-116510890 (+)
LP/J MGP_LPJ_G0035316
 protein coding gene Chr9:123082630-123112706 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035226
 protein coding gene Chr9:131753222-131784698 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035946
 protein coding gene Chr9:121633447-121664142 (+)
PWK/PhJ MGP_PWKPhJ_G0034121
 protein coding gene Chr9:118038041-118073341 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033957
 protein coding gene Chr9:121723483-121762148 (+)
WSB/EiJ MGP_WSBEiJ_G0034536
 protein coding gene Chr9:121519460-121549600 (+)



Homology
more
  • Human Ortholog
    TTC21A, tetratricopeptide repeat domain 21A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TTC21A, tetratricopeptide repeat domain 21A
  • Synonyms
    IFT139A, SPGF37, STI2, Thm2
  • Links
    NCBI Gene ID: 199223
    neXtProt AC: NX_Q8NDW8
    UniProt: Q8NDW8

  • Chr Location
    3p22.2; chr3:39107680-39138903 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TTC21A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility and asthenoteratospermia characterized by reduced sperm motility and multiple sperm malformations affecting the flagella and the connecting piece.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    766
  • Tissues
    4
  • cDNA Data
    18
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032514 Ensembl Gene Model | MGI Sequence Detail 30188 C57BL/6J ±  kb
    transcript ENSMUST00000035100 Ensembl | MGI Sequence Detail 4182 Not Applicable  
    polypeptide ENSMUSP00000035100 Ensembl | MGI Sequence Detail 1314 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:3035025
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:339134 Bumann EE, et al., Genetic Interaction of Thm2 and Thm1 Shapes Postnatal Craniofacial Bone. J Dev Biol. 2022 May 11;10(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory