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Abcb6 Gene Detail
Summary
  • Symbol
    Abcb6
  • Name
    ATP-binding cassette, sub-family B member 6
  • Synonyms
    1200005B17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921354
    NCBI Gene: 74104
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:75148361-75157036 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 38.62 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    300 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921354
 protein coding gene Chr1:75148284-75157066 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016174
 protein coding gene Chr1:75733958-75742631 (-)
A/J MGP_AJ_G0016157
 protein coding gene Chr1:73093503-73102177 (-)
AKR/J MGP_AKRJ_G0016114
 protein coding gene Chr1:75122487-75131164 (-)
BALB/cJ MGP_BALBcJ_G0016112
 protein coding gene Chr1:73155509-73164182 (-)
C3H/HeJ MGP_C3HHeJ_G0015943
 protein coding gene Chr1:75453083-75461757 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016565
 protein coding gene Chr1:78684467-78693140 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014286
 protein coding gene Chr1:68654359-68663124 (-)
CAST/EiJ MGP_CASTEiJ_G0015527
 protein coding gene Chr1:74789739-74798422 (-)
CBA/J MGP_CBAJ_G0015916
 protein coding gene Chr1:81242680-81251354 (-)
DBA/2J MGP_DBA2J_G0016017
 protein coding gene Chr1:72412417-72421090 (-)
FVB/NJ MGP_FVBNJ_G0016020
 protein coding gene Chr1:71610679-71619357 (-)
LP/J MGP_LPJ_G0016089
 protein coding gene Chr1:76857884-76866557 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016040
 protein coding gene Chr1:84600914-84609586 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016612
 protein coding gene Chr1:75192321-75200994 (-)
PWK/PhJ MGP_PWKPhJ_G0015314
 protein coding gene Chr1:71881983-71890738 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015092
 protein coding gene Chr1:74552771-74561433 (-)
WSB/EiJ MGP_WSBEiJ_G0015589
 protein coding gene Chr1:75003578-75012249 (-)



Homology
more
  • Human Ortholog
    ABCB6, ATP binding cassette subfamily B member 6 (LAN blood group)
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABCB6, ATP binding cassette subfamily B member 6 (LAN blood group)
  • Synonyms
    ABC, LAN, MTABC3, PRP, umat
  • Links
    NCBI Gene ID: 10058
    neXtProt AC: NX_Q9NP58
    UniProt: Q9NP58

  • Chr Location
    2q35; chr2:219209772-219218994 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ABCB6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display partial lethality, impaired stress erythropoiesis, and absence of ATP-dependent transport of Coproporphyrin III in mitochondria.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    79
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    891
  • Tissues
    138
  • cDNA Data
    81
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026198 Ensembl Gene Model | MGI Sequence Detail 8676 C57BL/6J ±  kb
    transcript ENSMUST00000027396 Ensembl | MGI Sequence Detail 2966 Not Applicable  
    polypeptide ENSMUSP00000027396 Ensembl | MGI Sequence Detail 842 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000003551 ATP-binding cassette sub-family B member 6
      (term hierarchy)
    • EC
      7.6.2.5
    • InterPro Domains
      IPR003593 AAA+ ATPase domain
      IPR003439 ABC transporter-like, ATP-binding domain
      IPR017871 ABC transporter-like, conserved site
      IPR011527 ABC transporter type 1, transmembrane domain
      IPR036640 ABC transporter type 1, transmembrane domain superfamily
      IPR032410 Mitochondrial ABC-transporter, N-terminal five TM domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR039421 Type 1 protein exporter
    Molecular
    Reagents
    less
    • All nucleic 82
      cDNA 81
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 13
      Phenotypes 32
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:358605 Baril SA, et al., The role of ATP-binding Cassette subfamily B member 6 in the inner ear. Nat Commun. 2024 Nov 18;15(1):9885
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory