Parn MGI Mouse Gene Detail - MGI:1921358 - poly(A)-specific ribonuclease (deadenylation nuclease)

Symbol

Parn
Name

poly(A)-specific ribonuclease (deadenylation nuclease)
Synonyms

1200003I18Rik, DAN

Feature Type

protein coding gene
IDs

MGI:1921358
NCBI Gene: 74108
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr16:13355828-13486035 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 9.32 cM, cytoband B1
Mapping Data

3 experiments

SNPs within 2kb

3949 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921358	protein coding gene	Chr16:13355824-13486035 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022531	protein coding gene	Chr16:10506222-10648407 (-)
A/J	MGP_AJ_G0022493	protein coding gene	Chr16:9934530-10066555 (-)
AKR/J	MGP_AKRJ_G0022469	protein coding gene	Chr16:10366550-10503579 (-)
BALB/cJ	MGP_BALBcJ_G0022497	protein coding gene	Chr16:10095044-10230956 (-)
C3H/HeJ	MGP_C3HHeJ_G0022264	protein coding gene	Chr16:10455846-10596746 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022946	protein coding gene	Chr16:10669458-10815639 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020466	protein coding gene	Chr16:10030872-10160897 (-)
CAST/EiJ	MGP_CASTEiJ_G0021791	protein coding gene	Chr16:10460241-10602421 (-)
CBA/J	MGP_CBAJ_G0022233	protein coding gene	Chr16:11150569-11303890 (-)
DBA/2J	MGP_DBA2J_G0022364	protein coding gene	Chr16:9934948-10064543 (-)
FVB/NJ	MGP_FVBNJ_G0022340	protein coding gene	Chr16:9914969-10048291 (-)
LP/J	MGP_LPJ_G0022432	protein coding gene	Chr16:10429864-10564107 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022362	protein coding gene	Chr16:10798106-10960070 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022959	protein coding gene	Chr16:10343454-10480888 (-)
PWK/PhJ	MGP_PWKPhJ_G0021533	protein coding gene	Chr16:10189636-10322416 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021361	protein coding gene	Chr16:10328124-10463209 (-)
WSB/EiJ	MGP_WSBEiJ_G0021839	protein coding gene	Chr16:10353777-10491636 (-)

Human Ortholog

PARN, poly(A)-specific ribonuclease

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PARN, poly(A)-specific ribonuclease
Synonyms

DAN, DKCB6, PFBMFT4
Links

HGNC:8609

NCBI Gene ID: 5073

neXtProt AC: NX_O95453

UniProt: O95453
Chr Location

16p13.12; chr16:14435700-14632728 (-) GRCh38

MGI Vertebrate Homology

Parn stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PARN
Gene Tree

Parn

Diseases

1 with human PARN associations

				Human Disease	Mouse Models
				autosomal recessive dyskeratosis congenita 6 IDs autosomal recessive dyskeratosis congenita 6 DOID:0070024 OMIM:616353

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 2 alleles in 2 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Endonuclease-mediated

5
Gene trapped

17
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

55 strains or lines available

Mice homozygous for a null allele die prior to E11.5.

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All GO Annotations

33
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

725
Tissues

14
cDNA Data

115
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase parn

ZFIN parn

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All Sequences

57
RefSeq

14
UniProt

5
CCDS

CCDS37259.1

Ensembl

ENSMUSG00000022685 (Evidence)
NCBI Gene

74108

			Length	Strain/Species	Flank
genomic	74108	NCBI Gene Model \| MGI Sequence Detail	130208	C57BL/6J	± kb
transcript	NM_028761	RefSeq \| MGI Sequence Detail	2902	C57BL/6
polypeptide	Q8VDG3	UniProt \| EBI \| MGI Sequence Detail	624	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000012288 poly(A)-specific ribonuclease PARN

(term hierarchy)
PDB

1UG8, 1WHV, 2ROK, 3D45
EC

3.1.13.4
InterPro Domains

IPR051181 CAF1 family poly(A)-specific ribonucleases

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR034042 PARN, R3H domain

IPR014789 Poly(A)-specific ribonuclease, RNA-binding

IPR001374 R3H domain

IPR036867 R3H domain superfamily

IPR006941 Ribonuclease CAF1

IPR012337 Ribonuclease H-like superfamily

IPR036397 Ribonuclease H superfamily

IPR035979 RNA-binding domain superfamily
GlyGen

Q8VDG3 1 site, 1 O-linked glycan (1 site)

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All nucleic 116

cDNA 115

Primer pair 1

Microarray probesets 3

Summaries

All 42

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Parn:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr140044	Chr16:13485986-13486045 (-)	19 bp
Tssr140043	Chr16:13429612-13429617 (-)	56,420 bp
Tssr140042	Chr16:13359095-13359131 (-)	126,922 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24