Pi16 MGI Mouse Gene Detail - MGI:1921366

Symbol

Pi16
Name

peptidase inhibitor 16
Synonyms

1200009H11Rik

Feature Type

protein coding gene
IDs

MGI:1921366
NCBI Gene: 74116
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr17:29537770-29547876 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 15.22 cM, cytoband B1
Mapping Data

2 experiments

SNPs within 2kb

358 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921366	protein coding gene	Chr17:29536654-29549567 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023462	protein coding gene	Chr17:28842903-28854437 (+)
A/J	MGP_AJ_G0023420	protein coding gene	Chr17:27854232-27864487 (+)
AKR/J	MGP_AKRJ_G0023385	protein coding gene	Chr17:28083398-28095888 (+)
BALB/cJ	MGP_BALBcJ_G0023425	protein coding gene	Chr17:28115460-28127781 (+)
C3H/HeJ	MGP_C3HHeJ_G0023186	protein coding gene	Chr17:28472807-28483632 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023867	protein coding gene	Chr17:29988007-29998883 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021342	protein coding gene	Chr17:25178210-25187959 (+)
CAST/EiJ	MGP_CASTEiJ_G0022687	protein coding gene	Chr17:28447575-28458581 (+)
CBA/J	MGP_CBAJ_G0023161	protein coding gene	Chr17:31099049-31109319 (+)
DBA/2J	MGP_DBA2J_G0023291	protein coding gene	Chr17:27376918-27387181 (+)
FVB/NJ	MGP_FVBNJ_G0023261	protein coding gene	Chr17:27217916-27227650 (+)
LP/J	MGP_LPJ_G0023369	protein coding gene	Chr17:29093203-29105373 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023279	protein coding gene	Chr17:30442276-30455330 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023909	protein coding gene	Chr17:28550296-28563534 (+)
PWK/PhJ	MGP_PWKPhJ_G0022437	protein coding gene	Chr17:26220830-26230779 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022255	protein coding gene	Chr17:26528006-26538914 (+)
WSB/EiJ	MGP_WSBEiJ_G0022749	protein coding gene	Chr17:28503288-28516312 (+)

Human Ortholog

PI16, peptidase inhibitor 16

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PI16, peptidase inhibitor 16
Synonyms

CD364, CRISP9, MSMBBP, PSPBP
Links

HGNC:21245

NCBI Gene ID: 221476

neXtProt AC: NX_Q6UXB8

UniProt: Q6UXB8
Chr Location

6p21.2; chr6:36948263-36964837 (+) GRCh38

MGI Vertebrate Homology

Pi16 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PI16
Gene Tree

Pi16

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Phenotype Summary

18 phenotypes from 3 alleles in 3 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

5
Gene trapped

3
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant mice exhibited numerous immunological abnormalities during tissue-specific FACS analyses including an increased percentage of CD25+ cells in lymph node and B cell compartment differences in bone marrow spleen and lymph node.

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All GO Annotations

5
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

752
Tissues

8
cDNA Data

17
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

47
RefSeq

4
UniProt

3
CCDS

CCDS28595.2

Ensembl

ENSMUSG00000024011 (Evidence)
NCBI Gene

74116

			Length	Strain/Species	Flank
genomic	74116	NCBI Gene Model \| MGI Sequence Detail	10107	C57BL/6J	± kb
transcript	NM_023734	RefSeq \| MGI Sequence Detail	2245	C57BL/6
polypeptide	Q9ET66	UniProt \| EBI \| MGI Sequence Detail	498	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000012679 peptidase inhibitor 16

(term hierarchy)
InterPro Domains

IPR018244 Allergen V5/Tpx-1-related, conserved site

IPR014044 CAP domain

IPR035940 CAP superfamily

IPR001283 Cysteine-rich secretory protein-related
GlyGen

Q9ET66 2 sites

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All nucleic 19

Genomic 2

cDNA 17

Microarray probesets 4

Summaries

All 39

Developmental Gene Expression 4

Gene Ontology 3

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:349860 Hashimoto K, et al., Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics. Sci Rep. 2024 Jun 14;14(1):13727

TSS for Pi16:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143527	Chr17:29537824-29537860 (+)	72 bp
Tssr143528	Chr17:29538157-29538177 (+)	397 bp
Tssr5060	Chr17:29546074-29546084 (+)	8,309 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24