Actr3 MGI Mouse Gene Detail - MGI:1921367 - ARP3 actin-related protein 3

Symbol

Actr3
Name

ARP3 actin-related protein 3
Synonyms

1200003A09Rik, Arp3

Feature Type

protein coding gene
IDs

MGI:1921367
NCBI Gene: 74117
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr1:125320642-125363464 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 54.70 cM, cytoband E3
Mapping Data

2 experiments

SNPs within 2kb

889 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921367	protein coding gene	Chr1:125320642-125363464 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016414	protein coding gene	Chr1:128479717-128524372 (-)
A/J	MGP_AJ_G0016397	protein coding gene	Chr1:123752322-123798413 (-)
AKR/J	MGP_AKRJ_G0016362	protein coding gene	Chr1:127382336-127426792 (-)
BALB/cJ	MGP_BALBcJ_G0016357	protein coding gene	Chr1:124101470-124146506 (-)
C3H/HeJ	MGP_C3HHeJ_G0016183	protein coding gene	Chr1:127572576-127622120 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016818	protein coding gene	Chr1:133335417-133380337 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014531	protein coding gene	Chr1:117160317-117203054 (-)
CAST/EiJ	MGP_CASTEiJ_G0015764	protein coding gene	Chr1:126468588-126515324 (-)
CBA/J	MGP_CBAJ_G0016156	protein coding gene	Chr1:137859418-137906246 (-)
DBA/2J	MGP_DBA2J_G0016262	protein coding gene	Chr1:122760563-122803708 (-)
FVB/NJ	MGP_FVBNJ_G0016261	protein coding gene	Chr1:121496597-121540493 (-)
LP/J	MGP_LPJ_G0016333	protein coding gene	Chr1:129821771-129864705 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016286	protein coding gene	Chr1:143785644-143833860 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016854	protein coding gene	Chr1:127148855-127193697 (-)
PWK/PhJ	MGP_PWKPhJ_G0015550	protein coding gene	Chr1:121729212-121774073 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015338	protein coding gene	Chr1:126086416-126130379 (-)
WSB/EiJ	MGP_WSBEiJ_G0015826	protein coding gene	Chr1:127087590-127132396 (-)

Human Ortholog

ACTR3, actin related protein 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACTR3, actin related protein 3
Synonyms

ARP3
Links

HGNC:170

NCBI Gene ID: 10096

neXtProt AC: NX_P61158

UniProt: P61158
Chr Location

2q14.1; chr2:113889934-113962596 (+) GRCh38

MGI Vertebrate Homology

Actr3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ACTR3
Gene Tree

Actr3

Diseases

1 with human ACTR3 associations

				Human Disease	Mouse Models
				opisthorchiasis IDs opisthorchiasis DOID:13768 ICD10CM:B66.0 ICD9CM:121.0 MESH:D009889 UMLS_CUI:C0029106

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

2
Endonuclease-mediated

4
Gene trapped

10
Radiation induced

1
Genomic Mutations

3 involving Actr3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele die prior to E4.5 and exhibit abnormal embryogenesis.

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All GO Annotations

79
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

742
Tissues

17
cDNA Data

323
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase actr3

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All Sequences

105
RefSeq

6
UniProt

13
CCDS

CCDS15242.1

Ensembl

ENSMUSG00000026341 (Evidence)
NCBI Gene

74117

			Length	Strain/Species	Flank
genomic	74117	NCBI Gene Model \| MGI Sequence Detail	42823	C57BL/6J	± kb
transcript	NM_023735	RefSeq \| MGI Sequence Detail	2746	C57BL/6
polypeptide	Q99JY9	UniProt \| EBI \| MGI Sequence Detail	418	Not Applicable

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UniProt

13 Sequences
Protein Ontology

PR:000003696 actin-related protein 3

(term hierarchy)
PDB

7AQK
InterPro Domains

IPR020902 Actin/actin-like conserved site

IPR004000 Actin family

IPR043129 ATPase, nucleotide binding domain
GlyGen

Q99JY9 1 site, 1 O-linked glycan (1 site)

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All nucleic 324

cDNA 323

Primer pair 1

Microarray probesets 6

Summaries

All 74

Developmental Gene Expression 9

Gene Ontology 15

Phenotypes 12
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Actr3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr13388	Chr1:125363628-125363637 (-)	-169 bp
Tssr13387	Chr1:125363481-125363490 (-)	-22 bp
Tssr13386	Chr1:125363431-125363447 (-)	25 bp
Tssr13385	Chr1:125363398-125363425 (-)	52 bp
Tssr13384	Chr1:125363272-125363294 (-)	181 bp
Tssr13383	Chr1:125363211-125363269 (-)	224 bp
Tssr13382	Chr1:125363169-125363181 (-)	289 bp
Tssr13381	Chr1:125362513-125362527 (-)	944 bp
Tssr188	Chr1:125362321-125362346 (-)	1,130 bp
Tssr13380	Chr1:125362263-125362274 (-)	1,195 bp
Tssr13379	Chr1:125349898-125349913 (-)	13,558 bp
Tssr13378	Chr1:125349726-125349734 (-)	13,734 bp
Tssr13377	Chr1:125342460-125342473 (-)	20,997 bp
Tssr13376	Chr1:125330553-125330576 (-)	32,899 bp
Tssr13375	Chr1:125324317-125324330 (-)	39,140 bp
Tssr13374	Chr1:125321503-125321514 (-)	41,955 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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