Syvn1 MGI Mouse Gene Detail - MGI:1921376 - synovial apoptosis inhibitor 1, synoviolin

Symbol

Syvn1
Name

synovial apoptosis inhibitor 1, synoviolin
Synonyms

1200010C09Rik, Hrd1

Feature Type

protein coding gene
IDs

MGI:1921376
NCBI Gene: 74126
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr19:6096606-6103742 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 4.34 cM, cytoband A
Mapping Data

2 experiments

SNPs within 2kb

239 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921376	protein coding gene	Chr19:6096586-6103748 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024737	protein coding gene	Chr19:3074162-3081298 (+)
A/J	MGP_AJ_G0024703	protein coding gene	Chr19:2903272-2910420 (+)
AKR/J	MGP_AKRJ_G0024676	protein coding gene	Chr19:2993723-3000871 (+)
BALB/cJ	MGP_BALBcJ_G0024703	protein coding gene	Chr19:2898516-2905664 (+)
C3H/HeJ	MGP_C3HHeJ_G0024471	protein coding gene	Chr19:3012318-3019466 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025150	protein coding gene	Chr19:3133110-3140246 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022583	protein coding gene	Chr19:2832902-2840013 (+)
CAST/EiJ	MGP_CASTEiJ_G0023943	protein coding gene	Chr19:3019903-3027062 (+)
CBA/J	MGP_CBAJ_G0024443	protein coding gene	Chr19:3283227-3290374 (+)
DBA/2J	MGP_DBA2J_G0024570	protein coding gene	Chr19:2890401-2897548 (+)
FVB/NJ	MGP_FVBNJ_G0024536	protein coding gene	Chr19:2902215-2909366 (+)
LP/J	MGP_LPJ_G0024656	protein coding gene	Chr19:3054013-3061149 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024566	protein coding gene	Chr19:3103341-3110489 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025198	protein coding gene	Chr19:3022528-3029664 (+)
PWK/PhJ	MGP_PWKPhJ_G0023689	protein coding gene	Chr19:2922405-2929543 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023494	protein coding gene	Chr19:2981665-2988810 (+)
WSB/EiJ	MGP_WSBEiJ_G0024005	protein coding gene	Chr19:3028309-3035463 (+)

Human Ortholog

SYVN1, synoviolin 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SYVN1, synoviolin 1
Synonyms

DER3, HRD1
Links

HGNC:20738

NCBI Gene ID: 84447

neXtProt AC: NX_Q86TM6

UniProt: Q86TM6
Chr Location

11q13.1; chr11:65121780-65134532 (-) GRCh38

MGI Vertebrate Homology

Syvn1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SYVN1
Gene Tree

Syvn1

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

5
Gene trapped

4
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Haploinsufficiency results in embryonic death due to systemic abnormal apoptosis. Mice are viable when only a single copy is inactivated and they exhibit a resistance to collagen-induced arthritis due to enhanced apoptosis of synovial cells.

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All GO Annotations

46
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

719
Tissues

2
cDNA Data

139
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase syvn1

ZFIN syvn1

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All Sequences

63
RefSeq

7
UniProt

5
CCDS

CCDS29487.1

Ensembl

ENSMUSG00000024807 (Evidence)
NCBI Gene

74126

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024807	Ensembl Gene Model \| MGI Sequence Detail	7137	C57BL/6J	± kb
transcript	ENSMUST00000134667	Ensembl \| MGI Sequence Detail	3159	Not Applicable
polypeptide	ENSMUSP00000114960	Ensembl \| MGI Sequence Detail	612	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000015917 E3 ubiquitin-protein ligase synoviolin

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR050731 HRD1 family E3 ubiquitin-protein ligases

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

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All nucleic 140

cDNA 139

Primer pair 1

Microarray probesets 3

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MGI:2147717, MGI:2147800

Summaries

All 73

Developmental Gene Expression 4

Gene Ontology 15

Phenotypes 25
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345648 Lin LL, et al., SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD complex. Nat Commun. 2024 Feb 16;15(1):1440

TSS for Syvn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154538	Chr19:6096134-6096143 (+)	-467 bp
Tssr154539	Chr19:6096659-6096675 (+)	61 bp
Tssr154540	Chr19:6097051-6097071 (+)	455 bp
Tssr154541	Chr19:6097085-6097110 (+)	492 bp
Tssr154542	Chr19:6097111-6097133 (+)	516 bp
Tssr154544	Chr19:6101422-6101436 (+)	4,823 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24