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Smg8 Gene Detail
Summary
  • Symbol
    Smg8
  • Name
    SMG8 nonsense mediated mRNA decay factor
  • Synonyms
    1200011M11Rik, smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921383
    NCBI Gene: 74133
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:86968558-86977600 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 51.89 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    25 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921383
 protein coding gene Chr11:86968558-86977603 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018898
 protein coding gene Chr11:88653709-88662898 (-)
A/J MGP_AJ_G0018865
 protein coding gene Chr11:85247877-85257665 (-)
AKR/J MGP_AKRJ_G0018835
 protein coding gene Chr11:87793199-87802556 (-)
BALB/cJ MGP_BALBcJ_G0018838
 protein coding gene Chr11:85633189-85642489 (-)
C3H/HeJ MGP_C3HHeJ_G0018652
 protein coding gene Chr11:87816681-87825911 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019290
 protein coding gene Chr11:91327833-91336871 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016923
 protein coding gene Chr11:82275171-82284652 (-)
CAST/EiJ MGP_CASTEiJ_G0018207
 protein coding gene Chr11:88526591-88536469 (-)
CBA/J MGP_CBAJ_G0018623
 protein coding gene Chr11:95163635-95175981 (-)
DBA/2J MGP_DBA2J_G0018731
 protein coding gene Chr11:84808376-84817691 (-)
FVB/NJ MGP_FVBNJ_G0018720
 protein coding gene Chr11:84314567-84323463 (-)
LP/J MGP_LPJ_G0018801
 protein coding gene Chr11:89145409-89160275 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018747
 protein coding gene Chr11:95256352-95266815 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019330
 protein coding gene Chr11:88037025-88046231 (-)
PWK/PhJ MGP_PWKPhJ_G0017977
 protein coding gene Chr11:85620780-85630078 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017769
 protein coding gene Chr11:87600246-87609033 (-)
WSB/EiJ MGP_WSBEiJ_G0018258
 protein coding gene Chr11:87914339-87923926 (-)



Homology
more
  • Human Ortholog
    SMG8, SMG8 nonsense mediated mRNA decay factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMG8, SMG8 nonsense mediated mRNA decay factor
  • Synonyms
    ALKUS, C17orf71
  • Links
    NCBI Gene ID: 55181
    neXtProt AC: NX_Q8ND04
    UniProt: Q8ND04

  • Chr Location
    17q22; chr17:59209400-59215239 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Smg8
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    31 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    50
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020495 Ensembl Gene Model | MGI Sequence Detail 9043 C57BL/6J ±  kb
transcript ENSMUST00000020801 Ensembl | MGI Sequence Detail 3218 Not Applicable  
polypeptide ENSMUSP00000020801 Ensembl | MGI Sequence Detail 991 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000029140 nonsense-mediated mRNA decay factor SMG8
    (term hierarchy)
  • InterPro Domains
    IPR019354 Nonsense-mediated mRNA decay factor SMG8-like
  • GlyGen
    Q8VE18 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 50
    cDNA 50

    Microarray probesets 3
References
more
  • Summaries
    All 35
    Gene Ontology 3
    Phenotypes 13
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory