Sec14l1 MGI Mouse Gene Detail - MGI:1921386 - SEC14-like lipid binding 1

Symbol

Sec14l1
Name

SEC14-like lipid binding 1
Synonyms

1200017E04Rik, 2810012L19Rik

Feature Type

protein coding gene
IDs

MGI:1921386
NCBI Gene: 74136
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:117005994-117050094 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 81.99 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

1229 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921386	protein coding gene	Chr11:117005994-117050094 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019445	protein coding gene	Chr11:121315205-121362129 (+)
A/J	MGP_AJ_G0019413	protein coding gene	Chr11:115955253-116001152 (+)
AKR/J	MGP_AKRJ_G0019383	protein coding gene	Chr11:119493242-119538540 (+)
BALB/cJ	MGP_BALBcJ_G0019388	protein coding gene	Chr11:116334971-116380149 (+)
C3H/HeJ	MGP_C3HHeJ_G0019194	protein coding gene	Chr11:119773432-119818611 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019837	protein coding gene	Chr11:125032284-125082569 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017462	protein coding gene	Chr11:112980583-113026413 (+)
CAST/EiJ	MGP_CASTEiJ_G0018748	protein coding gene	Chr11:121193105-121238983 (+)
CBA/J	MGP_CBAJ_G0019165	protein coding gene	Chr11:129929949-129973910 (+)
DBA/2J	MGP_DBA2J_G0019277	protein coding gene	Chr11:115365487-115410396 (+)
FVB/NJ	MGP_FVBNJ_G0019269	protein coding gene	Chr11:114968135-115013024 (+)
LP/J	MGP_LPJ_G0019347	protein coding gene	Chr11:121655729-121700964 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019302	protein coding gene	Chr11:128973800-129021524 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019876	protein coding gene	Chr11:120135580-120182821 (+)
PWK/PhJ	MGP_PWKPhJ_G0018513	protein coding gene	Chr11:116708054-116753446 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018306	protein coding gene	Chr11:119860662-119904106 (+)
WSB/EiJ	MGP_WSBEiJ_G0018800	protein coding gene	Chr11:120090465-120135355 (+)

Human Ortholog

SEC14L1, SEC14 like lipid binding 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SEC14L1, SEC14 like lipid binding 1
Synonyms

PRELID4A, SEC14L
Links

HGNC:10698

NCBI Gene ID: 6397

neXtProt AC: NX_Q92503

UniProt: Q92503
Chr Location

17q25.2-q25.3; chr17:77088685-77217101 (+) GRCh38

MGI Vertebrate Homology

Sec14l1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SEC14L1
Gene Tree

Sec14l1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

36
Endonuclease-mediated

1
Gene trapped

33
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

21
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

742
Tissues

6
cDNA Data

242
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sec14l1

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All Sequences

68
RefSeq

11
UniProt

3
CCDS

CCDS25683.1, CCDS48988.1, CCDS48989.1

Ensembl

ENSMUSG00000020823 (Evidence)
NCBI Gene

74136

			Length	Strain/Species	Flank
genomic	74136	NCBI Gene Model \| MGI Sequence Detail	44101	C57BL/6J	± kb
transcript	NM_001166506	RefSeq \| MGI Sequence Detail	4724	C57BL/6
polypeptide	A8Y5H7	UniProt \| EBI \| MGI Sequence Detail	715	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014576 SEC14-like protein 1

(term hierarchy)
InterPro Domains

IPR001251 CRAL-TRIO lipid binding domain

IPR036865 CRAL-TRIO lipid binding domain superfamily

IPR011074 CRAL/TRIO, N-terminal domain

IPR036273 CRAL/TRIO, N-terminal domain superfamily

IPR009038 GOLD domain

IPR036598 GOLD domain superfamily

IPR006797 PRELI/MSF1 domain

IPR051064 SEC14-like and CRAL-TRIO domain-containing protein

IPR037365 Slowmo/Ups family

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All nucleic 243

cDNA 242

Primer pair 1

Microarray probesets 5

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MGI:1916492

Summaries

All 33

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sec14l1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr106018	Chr11:117005959-117006012 (+)	-8 bp
Tssr106019	Chr11:117006021-117006083 (+)	58 bp
Tssr106020	Chr11:117006085-117006111 (+)	104 bp
Tssr106021	Chr11:117034642-117034691 (+)	28,673 bp
Tssr106022	Chr11:117047192-117047211 (+)	41,208 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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