Fbxl22 MGI Mouse Gene Detail - MGI:1921415 - F-box and leucine-rich repeat protein 22

Symbol

Fbxl22
Name

F-box and leucine-rich repeat protein 22
Synonyms

1110004B15Rik

Feature Type

protein coding gene
IDs

MGI:1921415
NCBI Gene: 74165
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr9:66415657-66421891 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 35.96 cM
Mapping Data

1 experiment

SNPs within 2kb

187 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921415	protein coding gene	Chr9:66415657-66425752 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034976	protein coding gene	Chr9:66354021-66360149 (-)
A/J	MGP_AJ_G0034956	protein coding gene	Chr9:64061764-64067903 (-)
AKR/J	MGP_AKRJ_G0034886	protein coding gene	Chr9:65604534-65610669 (-)
BALB/cJ	MGP_BALBcJ_G0034949	protein coding gene	Chr9:63786993-63793128 (-)
C3H/HeJ	MGP_C3HHeJ_G0034658	protein coding gene	Chr9:66121754-66127889 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035468	protein coding gene	Chr9:68166204-68172333 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032379	protein coding gene	Chr9:63707011-63713232 (-)
CAST/EiJ	MGP_CASTEiJ_G0033980	protein coding gene	Chr9:66336937-66343056 (-)
CBA/J	MGP_CBAJ_G0034630	protein coding gene	Chr9:70505142-70511273 (-)
DBA/2J	MGP_DBA2J_G0034789	protein coding gene	Chr9:63841486-63847619 (-)
FVB/NJ	MGP_FVBNJ_G0034731	protein coding gene	Chr9:63185622-63191749 (-)
LP/J	MGP_LPJ_G0034872	protein coding gene	Chr9:66601406-66607541 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034773	protein coding gene	Chr9:71755932-71762067 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035490	protein coding gene	Chr9:65705731-65711869 (-)
PWK/PhJ	MGP_PWKPhJ_G0033684	protein coding gene	Chr9:64047595-64053727 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033518	protein coding gene	Chr9:66008865-66014971 (-)
WSB/EiJ	MGP_WSBEiJ_G0034093	protein coding gene	Chr9:65603337-65609465 (-)

Human Ortholog

FBXL22, F-box and leucine rich repeat protein 22

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FBXL22, F-box and leucine rich repeat protein 22
Synonyms

Fbl22
Links

HGNC:27537

NCBI Gene ID: 283807

neXtProt AC: NX_Q6P050

UniProt: Q6P050
Chr Location

15q22.31; chr15:63597353-63608516 (+) GRCh38

MGI Vertebrate Homology

Fbxl22 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FBXL22
Gene Tree

Fbxl22

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

3
Genomic Mutations

1 involving Fbxl22
Incidental Mutations

CvDC
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1074
Tissues

63
cDNA Data

10
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fbxl22

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All Sequences

39
RefSeq

4
UniProt

2
CCDS

CCDS23304.1

Ensembl

ENSMUSG00000050503 (Evidence)
NCBI Gene

74165

			Length	Strain/Species	Flank
genomic	ENSMUSG00000050503	Ensembl Gene Model \| MGI Sequence Detail	6235	C57BL/6J	± kb
transcript	ENSMUST00000056890	Ensembl \| MGI Sequence Detail	4035	Not Applicable
polypeptide	ENSMUSP00000060137	Ensembl \| MGI Sequence Detail	236	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009935 leucine-rich repeat-containing protein 29

(term hierarchy)
InterPro Domains

IPR001810 F-box domain

IPR036047 F-box-like domain superfamily

IPR006553 Leucine-rich repeat, cysteine-containing subtype

IPR032675 Leucine-rich repeat domain superfamily

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All nucleic 10

cDNA 10

Microarray probesets 4

Summaries

All 36

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fbxl22:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr90246	Chr9:66421849-66421879 (-)	27 bp
Tssr90245	Chr9:66421822-66421845 (-)	57 bp
Tssr90244	Chr9:66421815-66421818 (-)	74 bp
Tssr90243	Chr9:66421782-66421808 (-)	96 bp
Tssr90242	Chr9:66419735-66419770 (-)	2,138 bp
Tssr90241	Chr9:66419007-66419056 (-)	2,859 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24