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P2ry13 Gene Detail
Summary
  • Symbol
    P2ry13
  • Name
    purinergic receptor P2Y, G-protein coupled 13
  • Synonyms
    2010001L06Rik, Gpr86, P2Y13, SP174
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921441
    NCBI Gene: 74191
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:59115313-59118303 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 29.01 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    170 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921441
 protein coding gene Chr3:59115313-59118303 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027245
 protein coding gene Chr3:58086945-58089935 (-)
A/J MGP_AJ_G0027205
 protein coding gene Chr3:56268650-56271640 (-)
AKR/J MGP_AKRJ_G0027175
 protein coding gene Chr3:57440074-57443064 (-)
BALB/cJ MGP_BALBcJ_G0027218
 protein coding gene Chr3:56075980-56078970 (-)
C3H/HeJ MGP_C3HHeJ_G0026961
 protein coding gene Chr3:57659978-57662968 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027664
 protein coding gene Chr3:60225236-60228226 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025018
 protein coding gene Chr3:52626802-52629793 (-)
CAST/EiJ MGP_CASTEiJ_G0026413
 protein coding gene Chr3:57829129-57832119 (-)
CBA/J MGP_CBAJ_G0026937
 protein coding gene Chr3:62218934-62221924 (-)
DBA/2J MGP_DBA2J_G0027071
 protein coding gene Chr3:55779591-55782581 (-)
FVB/NJ MGP_FVBNJ_G0027039
 protein coding gene Chr3:54730813-54733803 (-)
LP/J MGP_LPJ_G0027183
 protein coding gene Chr3:58844230-58847220 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027057
 protein coding gene Chr3:66366732-66369722 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027722
 protein coding gene Chr3:57405690-57408680 (-)
PWK/PhJ MGP_PWKPhJ_G0026145
 protein coding gene Chr3:55408901-55411890 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025958
 protein coding gene Chr3:57111705-57114690 (-)
WSB/EiJ MGP_WSBEiJ_G0026487
 protein coding gene Chr3:57485946-57488936 (-)



Homology
more
  • Human Ortholog
    P2RY13, purinergic receptor P2Y13
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    P2RY13, purinergic receptor P2Y13
  • Synonyms
    FKSG77, GPCR1, GPR86, GPR94, P2Y13, SP174
  • Links
    NCBI Gene ID: 53829
    neXtProt AC: NX_Q9BPV8
    UniProt: Q9BPV8

  • Chr Location
    3q25.1; chr3:151326312-151329549 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired bile flow, biliary cholesterol secretion, and bile acid secretion, decreased liver cholesterol level, and reduced macrophage-to-feces reverse cholesterol transport.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    9
  • cDNA Data
    18
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74191 NCBI Gene Model | MGI Sequence Detail 2991 C57BL/6J ±  kb
    transcript NM_028808 RefSeq | MGI Sequence Detail 2541 C57BL/6  
    polypeptide Q9D8I2 UniProt | EBI | MGI Sequence Detail 337 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 2
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 9
      Phenotypes 17
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory