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Gsdma2 Gene Detail
Summary
  • Symbol
    Gsdma2
  • Name
    gasdermin A2
  • Synonyms
    2200001G21Rik, 2210006M16Rik, 2210009F20Rik, 2210411P14Rik, Gsdm2, Gsdml2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921490
    NCBI Gene: 76758
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:98537585-98548790 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 62.28 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    700 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921490
 protein coding gene Chr11:98537569-98548791 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019066
 protein coding gene Chr11:101233619-101249630 (+)
A/J MGP_AJ_G0019034
 protein coding gene Chr11:97002133-97013539 (+)
AKR/J MGP_AKRJ_G0019004
 protein coding gene Chr11:100005344-100021625 (+)
BALB/cJ MGP_BALBcJ_G0019008
 protein coding gene Chr11:97491103-97506072 (+)
C3H/HeJ MGP_C3HHeJ_G0018821
 protein coding gene Chr11:100139222-100151210 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019459
 protein coding gene Chr11:104303152-104335886 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017091
 protein coding gene Chr11:94542202-94585698 (+)
CAST/EiJ MGP_CASTEiJ_G0018375
 protein coding gene Chr11:101130258-101142058 (+)
CBA/J MGP_CBAJ_G0018792
 protein coding gene Chr11:108644767-108664765 (+)
DBA/2J MGP_DBA2J_G0018900
 protein coding gene Chr11:96536723-96573282 (+)
FVB/NJ MGP_FVBNJ_G0018889
 protein coding gene Chr11:96059902-96070371 (+)
LP/J MGP_LPJ_G0018970
 protein coding gene Chr11:101697142-101717979 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018916
 protein coding gene Chr11:108400622-108411167 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019499
 protein coding gene Chr11:100347750-100360455 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0017936
 protein coding gene Chr11:100111684-100114898 (-)
WSB/EiJ MGP_WSBEiJ_G0018424
 protein coding gene Chr11:100271675-100311427 (+)



Homology
more
  • Human Ortholog
    GSDMA, gasdermin A
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GSDMA, gasdermin A
  • Synonyms
    FKSG9, GSDM, GSDM1
  • Links
    NCBI Gene ID: 284110
    neXtProt AC: NX_Q96QA5
    UniProt: Q96QA5

  • Chr Location
    17q21.1; chr17:39953263-39977768 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    20
  • cDNA Data
    10
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000017211 Ensembl Gene Model | MGI Sequence Detail 11206 C57BL/6J ±  kb
transcript ENSMUST00000093938 Ensembl | MGI Sequence Detail 1673 Not Applicable  
polypeptide ENSMUSP00000091470 Ensembl | MGI Sequence Detail 443 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 11
    Primer pair 1

    Microarray probesets 8
Other
Accession IDs
less
MGI:1917308, MGI:1924008, MGI:1925572
References
more
  • Summaries
    All 35
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
  • Latest
    J:349394 Fattinger SA, et al., Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice. Proc Natl Acad Sci U S A. 2023 Nov 28;120(48):e2315503120
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory