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Gpn1 Gene Detail
Summary
  • Symbol
    Gpn1
  • Name
    GPN-loop GTPase 1
  • Synonyms
    2410004J02Rik, Xab1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921504
    NCBI Gene: 74254
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:31652085-31670248 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 17.27 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    721 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921504
 protein coding gene Chr5:31652085-31670250 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029427
 protein coding gene Chr5:29515322-29534656 (+)
A/J MGP_AJ_G0029393
 protein coding gene Chr5:28566561-28586230 (+)
AKR/J MGP_AKRJ_G0029343
 protein coding gene Chr5:29718517-29736682 (+)
BALB/cJ MGP_BALBcJ_G0029404
 protein coding gene Chr5:29097579-29116105 (+)
C3H/HeJ MGP_C3HHeJ_G0029125
 protein coding gene Chr5:29727651-29756697 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029857
 protein coding gene Chr5:31344352-31362514 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027095
 protein coding gene Chr5:26169351-26190637 (+)
CAST/EiJ MGP_CASTEiJ_G0028535
 protein coding gene Chr5:28766454-28789529 (+)
CBA/J MGP_CBAJ_G0029093
 protein coding gene Chr5:31968780-31990314 (+)
DBA/2J MGP_DBA2J_G0029242
 protein coding gene Chr5:28728503-28746642 (+)
FVB/NJ MGP_FVBNJ_G0029200
 protein coding gene Chr5:28148847-28166991 (+)
LP/J MGP_LPJ_G0029327
 protein coding gene Chr5:29968244-29986991 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029229
 protein coding gene Chr5:32802219-32820380 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029891
 protein coding gene Chr5:29215703-29234958 (+)
PWK/PhJ MGP_PWKPhJ_G0028260
 protein coding gene Chr5:27882336-27900809 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028091
 protein coding gene Chr5:28678420-28697771 (+)
WSB/EiJ MGP_WSBEiJ_G0028616
 protein coding gene Chr5:29283701-29302874 (+)



Homology
more
  • Human Ortholog
    GPN1, GPN-loop GTPase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPN1, GPN-loop GTPase 1
  • Synonyms
    ATPBD1A, MBDIN, NTPBP, RPAP4, XAB1
  • Links
    NCBI Gene ID: 11321
    neXtProt AC: NX_Q9HCN4
    UniProt: Q9HCN4

  • Chr Location
    2p23.3; chr2:27628247-27651511 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    1 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro, blastocysts fail to hatch from the zona pellucida and die after 3 days in culture.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    717
  • Tissues
    6
  • cDNA Data
    87
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000064037 Ensembl Gene Model | MGI Sequence Detail 18164 C57BL/6J ±  kb
    transcript ENSMUST00000076949 Ensembl | MGI Sequence Detail 3144 Not Applicable  
    polypeptide ENSMUSP00000076217 Ensembl | MGI Sequence Detail 372 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 88
      cDNA 88

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2140891
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 5
      Phenotypes 32
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory