Gpn1 MGI Mouse Gene Detail - MGI:1921504

Symbol

Gpn1
Name

GPN-loop GTPase 1
Synonyms

2410004J02Rik, Xab1

Feature Type

protein coding gene
IDs

MGI:1921504
NCBI Gene: 74254
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr5:31652085-31670248 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 17.27 cM
Mapping Data

2 experiments

SNPs within 2kb

721 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921504	protein coding gene	Chr5:31652085-31670250 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029427	protein coding gene	Chr5:29515322-29534656 (+)
A/J	MGP_AJ_G0029393	protein coding gene	Chr5:28566561-28586230 (+)
AKR/J	MGP_AKRJ_G0029343	protein coding gene	Chr5:29718517-29736682 (+)
BALB/cJ	MGP_BALBcJ_G0029404	protein coding gene	Chr5:29097579-29116105 (+)
C3H/HeJ	MGP_C3HHeJ_G0029125	protein coding gene	Chr5:29727651-29756697 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029857	protein coding gene	Chr5:31344352-31362514 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027095	protein coding gene	Chr5:26169351-26190637 (+)
CAST/EiJ	MGP_CASTEiJ_G0028535	protein coding gene	Chr5:28766454-28789529 (+)
CBA/J	MGP_CBAJ_G0029093	protein coding gene	Chr5:31968780-31990314 (+)
DBA/2J	MGP_DBA2J_G0029242	protein coding gene	Chr5:28728503-28746642 (+)
FVB/NJ	MGP_FVBNJ_G0029200	protein coding gene	Chr5:28148847-28166991 (+)
LP/J	MGP_LPJ_G0029327	protein coding gene	Chr5:29968244-29986991 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029229	protein coding gene	Chr5:32802219-32820380 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029891	protein coding gene	Chr5:29215703-29234958 (+)
PWK/PhJ	MGP_PWKPhJ_G0028260	protein coding gene	Chr5:27882336-27900809 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028091	protein coding gene	Chr5:28678420-28697771 (+)
WSB/EiJ	MGP_WSBEiJ_G0028616	protein coding gene	Chr5:29283701-29302874 (+)

Human Ortholog

GPN1, GPN-loop GTPase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPN1, GPN-loop GTPase 1
Synonyms

ATPBD1A, MBDIN, NTPBP, RPAP4, XAB1
Links

HGNC:17030

NCBI Gene ID: 11321

neXtProt AC: NX_Q9HCN4

UniProt: Q9HCN4
Chr Location

2p23.3; chr2:27628247-27651511 (+) GRCh38

MGI Vertebrate Homology

Gpn1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GPN1
Gene Tree

Gpn1

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References

1 with disease annotations

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
1 images
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

8
Radiation induced

2
Spontaneous

1
Targeted

3
Genomic Mutations

5 involving Gpn1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro, blastocysts fail to hatch from the zona pellucida and die after 3 days in culture.

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All GO Annotations

13
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

717
Tissues

6
cDNA Data

87
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpn1

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All Sequences

56
RefSeq

8
UniProt

4
CCDS

CCDS19185.1

Ensembl

ENSMUSG00000064037 (Evidence)
NCBI Gene

74254

			Length	Strain/Species	Flank
genomic	ENSMUSG00000064037	Ensembl Gene Model \| MGI Sequence Detail	18164	C57BL/6J	± kb
transcript	ENSMUST00000076949	Ensembl \| MGI Sequence Detail	3144	Not Applicable
polypeptide	ENSMUSP00000076217	Ensembl \| MGI Sequence Detail	372	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000008180 GPN-loop GTPase 1

(term hierarchy)
EC

3.6.5.-
InterPro Domains

IPR003593 AAA+ ATPase domain

IPR004130 GPN-loop GTPase

IPR030230 GPN-loop GTPase 1

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

Q8VCE2 1 site, 1 N-linked glycan (1 site)

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All nucleic 88

cDNA 88

Microarray probesets 6

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MGI:2140891

Summaries

All 59

Developmental Gene Expression 2

Diseases 1

Gene Ontology 5

Phenotypes 32
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Gpn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45712	Chr5:31652080-31652122 (+)	16 bp
Tssr1449	Chr5:31652143-31652151 (+)	62 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24