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Aven Gene Detail
Summary
  • Symbol
    Aven
  • Name
    apoptosis, caspase activation inhibitor
  • Synonyms
    1700013A01Rik, 1700056A21Rik, mAven-L, mAven-S
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921518
    NCBI Gene: 74268
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:112323231-112461598 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 57.04 cM, cytoband E4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3165 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921518
 protein coding gene Chr2:112323231-112464918 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026293
 protein coding gene Chr2:114945964-115086881 (+)
A/J MGP_AJ_G0026254
 protein coding gene Chr2:110234887-110375298 (+)
AKR/J MGP_AKRJ_G0026233
 protein coding gene Chr2:113342873-113480136 (+)
BALB/cJ MGP_BALBcJ_G0026267
 protein coding gene Chr2:110499530-110633681 (+)
C3H/HeJ MGP_C3HHeJ_G0026012
 protein coding gene Chr2:113720563-113891954 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026714
 protein coding gene Chr2:118750924-118900445 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024094
 protein coding gene Chr2:105470876-105609253 (+)
CAST/EiJ MGP_CASTEiJ_G0025475
 protein coding gene Chr2:113992991-114139142 (+)
CBA/J MGP_CBAJ_G0025989
 protein coding gene Chr2:122896423-123057862 (+)
DBA/2J MGP_DBA2J_G0026128
 protein coding gene Chr2:109695521-109834494 (+)
FVB/NJ MGP_FVBNJ_G0026090
 protein coding gene Chr2:108579848-108713451 (+)
LP/J MGP_LPJ_G0026229
 protein coding gene Chr2:115239409-115381714 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026109
 protein coding gene Chr2:127296699-127437984 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026769
 protein coding gene Chr2:113401480-113541075 (+)
PWK/PhJ MGP_PWKPhJ_G0025211
 protein coding gene Chr2:109200164-109338395 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025010
 protein coding gene Chr2:112581000-112719121 (+)
WSB/EiJ MGP_WSBEiJ_G0025544
 protein coding gene Chr2:114204328-114356332 (+)



Homology
more
  • Human Ortholog
    AVEN, apoptosis and caspase activation inhibitor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AVEN, apoptosis and caspase activation inhibitor
  • Synonyms
    PDCD12
  • Links
    NCBI Gene ID: 57099
    neXtProt AC: NX_Q9NQS1
    UniProt: Q9NQS1

  • Chr Location
    15q14; chr15:33851781-34075325 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    48
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    41
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Aven
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    41 strains or lines available
Mice homozygous for a reporter allele exhibit increased cell death in response to various apoptotic stimuli.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    776
  • Tissues
    17
  • cDNA Data
    16
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 74268 NCBI Gene Model | MGI Sequence Detail 138368 C57BL/6J ±  kb
transcript NM_028844 RefSeq | MGI Sequence Detail 1442 C57BL/6  
polypeptide Q9D9K3 UniProt | EBI | MGI Sequence Detail 342 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    cDNA 16
    Primer pair 6

    Microarray probesets 4
Other
Accession IDs
less
MGI:1916615
References
more
  • Summaries
    All 38
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory