Spatc1 MGI Mouse Gene Detail - MGI:1921531 - spermatogenesis and centriole associated 1

Symbol

Spatc1
Name

spermatogenesis and centriole associated 1
Synonyms

1700084J23Rik, speriolin

Feature Type

protein coding gene
IDs

MGI:1921531
NCBI Gene: 74281
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr15:76152289-76176772 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 35.63 cM, cytoband E1
Mapping Data

2 experiments

SNPs within 2kb

744 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921531	protein coding gene	Chr15:76150731-76176777 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021980	protein coding gene	Chr15:76332659-76359484 (+)
A/J	MGP_AJ_G0021938	protein coding gene	Chr15:73554649-73579306 (+)
AKR/J	MGP_AKRJ_G0021921	protein coding gene	Chr15:75547868-75576612 (+)
BALB/cJ	MGP_BALBcJ_G0021947	protein coding gene	Chr15:73582027-73606364 (+)
C3H/HeJ	MGP_C3HHeJ_G0021719	protein coding gene	Chr15:75595416-75621761 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022387	protein coding gene	Chr15:79187236-79213289 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019916	protein coding gene	Chr15:70216911-70242067 (+)
CAST/EiJ	MGP_CASTEiJ_G0021238	protein coding gene	Chr15:76396331-76420720 (+)
CBA/J	MGP_CBAJ_G0021686	protein coding gene	Chr15:81683981-81709416 (+)
DBA/2J	MGP_DBA2J_G0021811	protein coding gene	Chr15:73092343-73116381 (+)
FVB/NJ	MGP_FVBNJ_G0021792	protein coding gene	Chr15:72139058-72163633 (+)
LP/J	MGP_LPJ_G0021882	protein coding gene	Chr15:76424880-76451772 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021816	protein coding gene	Chr15:87012124-87040347 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022407	protein coding gene	Chr15:75791217-75819357 (+)
PWK/PhJ	MGP_PWKPhJ_G0020979	protein coding gene	Chr15:73238097-73263576 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020819	protein coding gene	Chr15:75514826-75540616 (+)
WSB/EiJ	MGP_WSBEiJ_G0021290	protein coding gene	Chr15:75883612-75909846 (+)

Human Ortholog

SPATC1, spermatogenesis and centriole associated 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SPATC1, spermatogenesis and centriole associated 1
Synonyms

SPATA15
Links

HGNC:30510

NCBI Gene ID: 375686

neXtProt AC: NX_Q76KD6

UniProt: Q76KD6
Chr Location

8q24.3; chr8:144010977-144047114 (+) GRCh38

MGI Vertebrate Homology

Spatc1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SPATC1
Gene Tree

Spatc1

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

3
Endonuclease-mediated

2
Gene trapped

3
Radiation induced

2
Targeted

3
Genomic Mutations

5 involving Spatc1
Incidental Mutations

APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

6
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

4
cDNA Data

3
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

51
RefSeq

20
UniProt

3
CCDS

CCDS27564.1

Ensembl

ENSMUSG00000049653 (Evidence)
NCBI Gene

74281

			Length	Strain/Species	Flank
genomic	ENSMUSG00000049653	Ensembl Gene Model \| MGI Sequence Detail	24484	C57BL/6J	± kb
transcript	ENSMUST00000074173	Ensembl \| MGI Sequence Detail	1605	Not Applicable
polypeptide	ENSMUSP00000073805	Ensembl \| MGI Sequence Detail	480	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000015498 speriolin

(term hierarchy)
InterPro Domains

IPR026715 Speriolin

IPR029384 Speriolin, C-terminal

IPR029385 Speriolin, N-terminal

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All nucleic 3

cDNA 3

Microarray probesets 2

Summaries

All 50

Developmental Gene Expression 1

Diseases 1

Gene Ontology 3

Phenotypes 31
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Spatc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131752	Chr15:76150720-76150731 (+)	-1,563 bp
Tssr131753	Chr15:76150755-76150776 (+)	-1,523 bp
Tssr131754	Chr15:76150784-76150793 (+)	-1,500 bp
Tssr131755	Chr15:76151149-76151162 (+)	-1,133 bp
Tssr131756	Chr15:76152276-76152293 (+)	-4 bp
Tssr4639	Chr15:76154192-76154202 (+)	1,908 bp
Tssr4640	Chr15:76154203-76154213 (+)	1,919 bp
Tssr131757	Chr15:76155134-76155145 (+)	2,851 bp
Tssr131758	Chr15:76155161-76155178 (+)	2,881 bp
Tssr4641	Chr15:76155185-76155188 (+)	2,898 bp
Tssr131759	Chr15:76158333-76158340 (+)	6,048 bp
Tssr131760	Chr15:76158423-76158430 (+)	6,138 bp
Tssr131761	Chr15:76158431-76158436 (+)	6,145 bp
Tssr131762	Chr15:76158558-76158575 (+)	6,278 bp
Tssr131763	Chr15:76158590-76158602 (+)	6,307 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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