Kcmf1 MGI Mouse Gene Detail - MGI:1921537 - potassium channel modulatory factor 1

Symbol

Kcmf1
Name

potassium channel modulatory factor 1
Synonyms

1700094M07Rik, clone DEBT-91, Pmcf

Feature Type

protein coding gene
IDs

MGI:1921537
NCBI Gene: 74287
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr6:72818097-72876962 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 32.30 cM, cytoband C3
Mapping Data

3 experiments

SNPs within 2kb

1072 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921537	protein coding gene	Chr6:72818097-72876962 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030884	protein coding gene	Chr6:73438391-73501357 (-)
A/J	MGP_AJ_G0030854	protein coding gene	Chr6:70576186-70635163 (-)
AKR/J	MGP_AKRJ_G0030783	protein coding gene	Chr6:72670797-72728801 (-)
BALB/cJ	MGP_BALBcJ_G0030865	protein coding gene	Chr6:70601794-70659241 (-)
C3H/HeJ	MGP_C3HHeJ_G0030847	protein coding gene	Chr6:111527502-111590017 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031323	protein coding gene	Chr6:75350400-75418384 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028512	protein coding gene	Chr6:69712668-69769826 (-)
CAST/EiJ	MGP_CASTEiJ_G0029973	protein coding gene	Chr6:72529462-72591333 (-)
CBA/J	MGP_CBAJ_G0030552	protein coding gene	Chr6:78434249-78504506 (-)
DBA/2J	MGP_DBA2J_G0030704	protein coding gene	Chr6:69962373-70019083 (-)
FVB/NJ	MGP_FVBNJ_G0030657	protein coding gene	Chr6:69357606-69415175 (-)
LP/J	MGP_LPJ_G0030783	protein coding gene	Chr6:73340377-73406224 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030692	protein coding gene	Chr6:81795568-81861965 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031349	protein coding gene	Chr6:72487688-72550031 (-)
PWK/PhJ	MGP_PWKPhJ_G0029689	protein coding gene	Chr6:68888208-68948924 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029517	protein coding gene	Chr6:71229074-71291626 (-)
WSB/EiJ	MGP_WSBEiJ_G0030055	protein coding gene	Chr6:72859055-72922120 (-)

Human Ortholog

KCMF1, potassium channel modulatory factor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KCMF1, potassium channel modulatory factor 1
Synonyms

DEBT91, FIGC, PCMF, ZZZ1
Links

HGNC:20589

NCBI Gene ID: 56888

neXtProt AC: NX_Q9P0J7

UniProt: Q9P0J7
Chr Location

2p11.2; chr2:84971093-85059472 (+) GRCh38

MGI Vertebrate Homology

Kcmf1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KCMF1
Gene Tree

Kcmf1

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
4 phenotypes from multigenic genotypes
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

164
Endonuclease-mediated

1
Gene trapped

161
Spontaneous

1
Targeted

1
Genomic Mutations

1 involving Kcmf1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

110 strains or lines available

Mice homozygous for a gene trapped allele exhibit some perinatal and postnatal lethality but mice that survive to adulthood exhibit normal lethality.

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All GO Annotations

19
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

734
Tissues

21
cDNA Data

106
Literature Summary

4

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kcmf1

ZFIN kcmf1

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All Sequences

51
RefSeq

4
UniProt

4
CCDS

CCDS39518.1, CCDS85066.1

Ensembl

ENSMUSG00000055239 (Evidence)
NCBI Gene

74287

			Length	Strain/Species	Flank
genomic	74287	NCBI Gene Model \| MGI Sequence Detail	58866	C57BL/6J	± kb
transcript	NM_019715	RefSeq \| MGI Sequence Detail	3251	ZRU/MplStud
polypeptide	Q80UY2	UniProt \| EBI \| MGI Sequence Detail	381	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000009249 E3 ubiquitin-protein ligase KCMF1

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR008598 Drought induced 19 protein type, zinc-binding domain

IPR050774 KCMF1 and Dystrophin

IPR013087 Zinc finger C2H2-type

IPR000433 Zinc finger, ZZ-type

IPR043145 Zinc finger, ZZ-type superfamily
GlyGen

Q80UY2 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 109

cDNA 107

Primer pair 2

Microarray probesets 5

Summaries

All 49

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 17
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:330636 Iwata S, et al., An efficient i-GONAD method for creating and maintaining lethal mutant mice using an inversion balancer identified from the C3H/HeJJcl strain. G3 (Bethesda). 2021;11(8)

TSS for Kcmf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr61496	Chr6:72877113-72877199 (-)	-194 bp
Tssr61495	Chr6:72876935-72876968 (-)	10 bp
Tssr61494	Chr6:72876882-72876934 (-)	54 bp
Tssr61493	Chr6:72876797-72876826 (-)	150 bp
Tssr61492	Chr6:72876705-72876794 (-)	212 bp
Tssr61491	Chr6:72876269-72876286 (-)	684 bp
Tssr61489	Chr6:72828259-72828264 (-)	48,700 bp
Tssr61488	Chr6:72819831-72819881 (-)	57,106 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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