About   Help   FAQ
Mtmr3 Gene Detail
Summary
  • Symbol
    Mtmr3
  • Name
    myotubularin related protein 3
  • Synonyms
    1700092A20Rik, FYVE-DSP1, mKIAA0371, ZFYVE10
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921552
    NCBI Gene: 74302
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:4430868-4544863 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 2.94 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2202 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921552
 protein coding gene Chr11:4430867-4544863 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017983
 protein coding gene Chr11:1447093-1564303 (-)
A/J MGP_AJ_G0017956
 protein coding gene Chr11:1429555-1543005 (-)
AKR/J MGP_AKRJ_G0017920
 protein coding gene Chr11:1493047-1607399 (-)
BALB/cJ MGP_BALBcJ_G0017924
 protein coding gene Chr11:1404526-1518978 (-)
C3H/HeJ MGP_C3HHeJ_G0017737
 protein coding gene Chr11:1387368-1503709 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018377
 protein coding gene Chr11:1516241-1634253 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016035
 protein coding gene Chr11:1309372-1440413 (-)
CAST/EiJ MGP_CASTEiJ_G0017299
 protein coding gene Chr11:1360330-1475931 (-)
CBA/J MGP_CBAJ_G0017712
 protein coding gene Chr11:1768030-1899558 (-)
DBA/2J MGP_DBA2J_G0017823
 protein coding gene Chr11:1333054-1447410 (-)
FVB/NJ MGP_FVBNJ_G0017814
 protein coding gene Chr11:1368543-1486086 (-)
LP/J MGP_LPJ_G0017893
 protein coding gene Chr11:1533663-1654493 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017840
 protein coding gene Chr11:1434597-1566137 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018416
 protein coding gene Chr11:1499472-1619535 (-)
PWK/PhJ MGP_PWKPhJ_G0017080
 protein coding gene Chr11:1337113-1456595 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016876
 protein coding gene Chr11:1466343-1583226 (-)
WSB/EiJ MGP_WSBEiJ_G0017353
 protein coding gene Chr11:1364131-1488446 (-)



Homology
more
  • Human Ortholog
    MTMR3, myotubularin related protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTMR3, myotubularin related protein 3
  • Synonyms
    FYVE-DSP1, ZFYVE10
  • Links
    NCBI Gene ID: 8897
    neXtProt AC: NX_Q13615
    UniProt: Q13615

  • Chr Location
    22q12.2; chr22:29883169-30030868 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in increased serum alkaline phosphatase level and, in males, impaired glucose tolerance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    929
  • Tissues
    146
  • cDNA Data
    161
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034354 Ensembl Gene Model | MGI Sequence Detail 113996 C57BL/6J ±  kb
    transcript ENSMUST00000123506 Ensembl | MGI Sequence Detail 5466 Not Applicable  
    polypeptide ENSMUSP00000122422 Ensembl | MGI Sequence Detail 1195 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 163
      cDNA 161
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2144089, MGI:2144577
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory