Dnajc14 MGI Mouse Gene Detail - MGI:1921580 - DnaJ heat shock protein family (Hsp40) member C14

Symbol

Dnajc14
Name

DnaJ heat shock protein family (Hsp40) member C14
Synonyms

5730551F12Rik, DRIP78, HDJ3, LIP6

Feature Type

protein coding gene
IDs

MGI:1921580
NCBI Gene: 74330
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr10:128641423-128655317 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 77.16 cM, cytoband D3
Mapping Data

2 experiments

SNPs within 2kb

241 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921580	protein coding gene	Chr10:128639931-128655317 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017884	protein coding gene	Chr10:132600217-132611719 (+)
A/J	MGP_AJ_G0017859	protein coding gene	Chr10:127260686-127273569 (+)
AKR/J	MGP_AKRJ_G0017822	protein coding gene	Chr10:130979033-130989172 (+)
BALB/cJ	MGP_BALBcJ_G0017823	protein coding gene	Chr10:127624765-127635074 (+)
C3H/HeJ	MGP_C3HHeJ_G0017646	protein coding gene	Chr10:131147301-131160481 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018278	protein coding gene	Chr10:137064862-137079237 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015956	protein coding gene	Chr10:121174252-121186303 (+)
CAST/EiJ	MGP_CASTEiJ_G0017207	protein coding gene	Chr10:131872495-131884467 (+)
CBA/J	MGP_CBAJ_G0017616	protein coding gene	Chr10:142657663-142672861 (+)
DBA/2J	MGP_DBA2J_G0017722	protein coding gene	Chr10:126318557-126329487 (+)
FVB/NJ	MGP_FVBNJ_G0017717	protein coding gene	Chr10:125241607-125252374 (+)
LP/J	MGP_LPJ_G0017796	protein coding gene	Chr10:133173278-133185138 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017745	protein coding gene	Chr10:145217005-145230376 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018318	protein coding gene	Chr10:131083352-131096397 (+)
PWK/PhJ	MGP_PWKPhJ_G0016992	protein coding gene	Chr10:126584551-126599293 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016781	protein coding gene	Chr10:130191407-130205172 (+)
WSB/EiJ	MGP_WSBEiJ_G0017266	protein coding gene	Chr10:131310543-131321633 (+)

Human Ortholog

DNAJC14, DnaJ heat shock protein family (Hsp40) member C14

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNAJC14, DnaJ heat shock protein family (Hsp40) member C14
Synonyms

DNAJ, DRIP78, HDJ3, LIP6
Links

HGNC:24581

NCBI Gene ID: 85406

neXtProt AC: NX_Q6Y2X3

UniProt: Q6Y2X3
Chr Location

12q13.2; chr12:55820960-55830824 (-) GRCh38

MGI Vertebrate Homology

Dnajc14 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DNAJC14
Gene Tree

Dnajc14

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Gene trapped

6
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

6
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

763
Tissues

46
cDNA Data

12
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dnajc14

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All Sequences

57
RefSeq

6
UniProt

4
CCDS

CCDS24294.1

Ensembl

ENSMUSG00000025354 (Evidence)
NCBI Gene

74330

			Length	Strain/Species	Flank
genomic	74330	NCBI Gene Model \| MGI Sequence Detail	13895	C57BL/6J	± kb
transcript	NM_001359825	RefSeq \| MGI Sequence Detail	4329	C57BL/6
polypeptide	Q921R4	UniProt \| EBI \| MGI Sequence Detail	703	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000006581 DnaJ homolog subfamily C member 14

(term hierarchy)
InterPro Domains

IPR036869 Chaperone J-domain superfamily

IPR032843 Cleavage inducing molecular chaperone, Jiv

IPR001623 DnaJ domain

IPR052317 Viral replication and host interaction regulator

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All nucleic 12

cDNA 12

Microarray probesets 5

Summaries

All 35

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dnajc14:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr96451	Chr10:128640624-128640651 (+)	-785 bp
Tssr96452	Chr10:128640880-128640901 (+)	-532 bp
Tssr96453	Chr10:128641398-128641459 (+)	6 bp
Tssr96454	Chr10:128641461-128641520 (+)	68 bp
Tssr96455	Chr10:128641521-128641563 (+)	119 bp
Tssr96456	Chr10:128641663-128641675 (+)	246 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24