Crtc2 MGI Mouse Gene Detail - MGI:1921593 - CREB regulated transcription coactivator 2

Symbol

Crtc2
Name

CREB regulated transcription coactivator 2
Synonyms

4632407F12Rik

Feature Type

protein coding gene
IDs

MGI:1921593
NCBI Gene: 74343
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr3:90161475-90171432 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 39.21 cM, cytoband F2
Mapping Data

2 experiments

SNPs within 2kb

183 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921593	protein coding gene	Chr3:90161470-90171432 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027459	protein coding gene	Chr3:90550243-90560205 (+)
A/J	MGP_AJ_G0027423	protein coding gene	Chr3:87538145-87548107 (+)
AKR/J	MGP_AKRJ_G0027388	protein coding gene	Chr3:89685942-89695904 (+)
BALB/cJ	MGP_BALBcJ_G0027432	protein coding gene	Chr3:87497712-87507674 (+)
C3H/HeJ	MGP_C3HHeJ_G0027174	protein coding gene	Chr3:89853034-89862996 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027878	protein coding gene	Chr3:93956241-93966203 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025231	protein coding gene	Chr3:83034514-83044432 (+)
CAST/EiJ	MGP_CASTEiJ_G0026620	protein coding gene	Chr3:90236787-90246747 (+)
CBA/J	MGP_CBAJ_G0027149	protein coding gene	Chr3:97193046-97203008 (+)
DBA/2J	MGP_DBA2J_G0027286	protein coding gene	Chr3:86907663-86917625 (+)
FVB/NJ	MGP_FVBNJ_G0027254	protein coding gene	Chr3:85244659-85254621 (+)
LP/J	MGP_LPJ_G0027395	protein coding gene	Chr3:91617975-91627937 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027275	protein coding gene	Chr3:103392631-103402589 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027937	protein coding gene	Chr3:89439192-89449154 (+)
PWK/PhJ	MGP_PWKPhJ_G0026354	protein coding gene	Chr3:86795801-86805841 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026174	protein coding gene	Chr3:88611693-88621648 (+)
WSB/EiJ	MGP_WSBEiJ_G0026702	protein coding gene	Chr3:89831636-89841594 (+)

Human Ortholog

CRTC2, CREB regulated transcription coactivator 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CRTC2, CREB regulated transcription coactivator 2
Synonyms

TORC-2, TORC2
Links

HGNC:27301

NCBI Gene ID: 200186

neXtProt AC: NX_Q53ET0

UniProt: Q53ET0
Chr Location

1q21.3; chr1:153947669-153958615 (-) GRCh38

MGI Vertebrate Homology

Crtc2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CRTC2
Gene Tree

Crtc2

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References

1 with disease annotations

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Phenotype Summary

10 phenotypes from 3 alleles in 3 genetic backgrounds
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

2
Radiation induced

1
Targeted

8
Genomic Mutations

2 involving Crtc2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased circulating corticosterone levels, hepatocyte secretion of glucose in response to glucagon, and glycogen levels in liver and muscle cells.

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All GO Annotations

27
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

808
Tissues

102
cDNA Data

51
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

68
RefSeq

13
UniProt

5
CCDS

CCDS38501.1

Ensembl

ENSMUSG00000027936 (Evidence)
NCBI Gene

74343

			Length	Strain/Species	Flank
genomic	74343	NCBI Gene Model \| MGI Sequence Detail	9958	C57BL/6J	± kb
transcript	NM_028881	RefSeq \| MGI Sequence Detail	2603	C57BL/6
polypeptide	Q3U182	UniProt \| EBI \| MGI Sequence Detail	692	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000005902 CREB-regulated transcription coactivator 2

(term hierarchy)
PDB

5ZK1, 5ZKO
InterPro Domains

IPR024786 CREB-regulated transcription coactivator

IPR024785 Transducer of regulated CREB activity, C-terminal

IPR024784 Transducer of regulated CREB activity, middle domain

IPR024783 Transducer of regulated CREB activity, N-terminal
GlyGen

Q3U182 6 sites, 1 O-linked glycan (6 sites)

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All nucleic 52

cDNA 51

Primer pair 1

Microarray probesets 4

Summaries

All 80

Developmental Gene Expression 2

Diseases 1

Gene Ontology 15

Phenotypes 29
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:338967 Han HS, et al., Impaired BCAA catabolism in adipose tissues promotes age-associated metabolic derangement. Nat Aging. 2023 Aug;3(8):982-1000

TSS for Crtc2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30178	Chr3:90160429-90160431 (+)	-1,045 bp
Tssr30179	Chr3:90161548-90161559 (+)	79 bp
Tssr30180	Chr3:90161566-90161639 (+)	128 bp
Tssr30181	Chr3:90161651-90161670 (+)	186 bp
Tssr30182	Chr3:90167589-90167592 (+)	6,116 bp
Tssr30183	Chr3:90168268-90168282 (+)	6,800 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24