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Meak7 Gene Detail
Summary
  • Symbol
    Meak7
  • Name
    MTOR associated protein, eak-7 homolog
  • Synonyms
    4632415K11Rik, Tldc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921597
    NCBI Gene: 74347
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:120486815-120505155 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 68.32 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    778 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921597
protein coding gene Chr8:120486802-120505173 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034192
protein coding gene Chr8:123117328-123135081 (-)
A/J MGP_AJ_G0034172
protein coding gene Chr8:118035890-118053747 (-)
AKR/J MGP_AKRJ_G0034099
protein coding gene Chr8:121466836-121484697 (-)
BALB/cJ MGP_BALBcJ_G0034166
protein coding gene Chr8:118241944-118260187 (-)
C3H/HeJ MGP_C3HHeJ_G0033877
protein coding gene Chr8:122191638-122212204 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034686
protein coding gene Chr8:127224763-127246230 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031628
protein coding gene Chr8:110930890-110949009 (-)
CAST/EiJ MGP_CASTEiJ_G0033204
protein coding gene Chr8:122141306-122158903 (-)
CBA/J MGP_CBAJ_G0033850
protein coding gene Chr8:131857036-131878638 (-)
DBA/2J MGP_DBA2J_G0034006
protein coding gene Chr8:117256990-117274635 (-)
FVB/NJ MGP_FVBNJ_G0033949
protein coding gene Chr8:116296667-116315535 (-)
LP/J MGP_LPJ_G0034095
protein coding gene Chr8:123249452-123267305 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033996
protein coding gene Chr8:134309082-134326893 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034704
protein coding gene Chr8:121618879-121639689 (-)
PWK/PhJ MGP_PWKPhJ_G0032906
protein coding gene Chr8:117013211-117031900 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032746
protein coding gene Chr8:120318918-120336715 (-)
WSB/EiJ MGP_WSBEiJ_G0033320
protein coding gene Chr8:122341199-122359015 (-)



Homology
more
  • Human Ortholog
    MEAK7, MTOR associated protein, eak-7 homolog
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MEAK7, MTOR associated protein, eak-7 homolog
  • Synonyms
    EAK7, KIAA1609, mEAK-7, TLDC1
  • Links
    NCBI Gene ID: 57707
    neXtProt AC: NX_Q6P9B6
    UniProt: Q6P9B6

  • Chr Location
    16q24.1; chr16:84476355-84554033 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034105 Ensembl Gene Model | MGI Sequence Detail 18341 C57BL/6J ±  kb
    transcript ENSMUST00000049156 Ensembl | MGI Sequence Detail 3085 Not Applicable  
    polypeptide ENSMUSP00000044430 Ensembl | MGI Sequence Detail 455 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 18
      Primer pair 1
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:6276257
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 5
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    12/10/2024
    MGI 6.24
    The Jackson Laboratory