Matcap1 MGI Mouse Gene Detail - MGI:1921606 - microtubule associated tyrosine carboxypeptidase 1

Symbol

Matcap1
Name

microtubule associated tyrosine carboxypeptidase 1
Synonyms

4931428F04Rik, MATCAP

Feature Type

protein coding gene
IDs

MGI:1921606
NCBI Gene: 74356
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr8:106007041-106016160 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 53.04 cM, cytoband D1
Mapping Data

3 experiments

SNPs within 2kb

267 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921606	protein coding gene	Chr8:106007041-106016496 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034035	protein coding gene	Chr8:107545727-107554747 (-)
A/J	MGP_AJ_G0034016	protein coding gene	Chr8:103258369-103267201 (-)
AKR/J	MGP_AKRJ_G0033942	protein coding gene	Chr8:106242378-106251155 (-)
BALB/cJ	MGP_BALBcJ_G0034009	protein coding gene	Chr8:103433527-103443782 (-)
C3H/HeJ	MGP_C3HHeJ_G0033721	protein coding gene	Chr8:106988238-106998485 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034529	protein coding gene	Chr8:111494928-111503973 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031471	protein coding gene	Chr8:96407833-96416669 (-)
CAST/EiJ	MGP_CASTEiJ_G0033047	protein coding gene	Chr8:106487182-106497598 (-)
CBA/J	MGP_CBAJ_G0033694	protein coding gene	Chr8:115092301-115101239 (-)
DBA/2J	MGP_DBA2J_G0033849	protein coding gene	Chr8:102603301-102612275 (-)
FVB/NJ	MGP_FVBNJ_G0033795	protein coding gene	Chr8:101526584-101536269 (-)
LP/J	MGP_LPJ_G0033940	protein coding gene	Chr8:107756852-107765667 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033838	protein coding gene	Chr8:118305124-118316729 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034547	protein coding gene	Chr8:106216364-106226155 (-)
PWK/PhJ	MGP_PWKPhJ_G0032748	protein coding gene	Chr8:101988131-101998761 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032589	protein coding gene	Chr8:104893487-104902924 (-)
WSB/EiJ	MGP_WSBEiJ_G0033163	protein coding gene	Chr8:106869465-106879560 (-)

Human Ortholog

MATCAP1, microtubule associated tyrosine carboxypeptidase 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MATCAP1, microtubule associated tyrosine carboxypeptidase 1
Synonyms

KIAA0895L, TMCP1
Links

HGNC:34408

NCBI Gene ID: 653319

neXtProt AC: NX_Q68EN5

UniProt: Q68EN5
Chr Location

16q22.1; chr16:67175599-67184040 (-) GRCh38

MGI Vertebrate Homology

Matcap1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: MATCAP1
Gene Tree

Matcap1

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
5 phenotypes from multigenic genotypes
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

3
Gene trapped

1
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit reduced brain size.

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

9
cDNA Data

8
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

50
RefSeq

10
UniProt

1
CCDS

CCDS22596.1

Ensembl

ENSMUSG00000014837 (Evidence)
NCBI Gene

74356

			Length	Strain/Species	Flank
genomic	74356	NCBI Gene Model \| MGI Sequence Detail	9120	C57BL/6J	± kb
transcript	NM_028888	RefSeq \| MGI Sequence Detail	3571	C57BL/6
polypeptide	Q810A5	UniProt \| EBI \| MGI Sequence Detail	467	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000059846 microtubule-associated tyrosine carboxypeptidase 1

(term hierarchy)
EC

3.4.17.17
InterPro Domains

IPR012548 Microtubule-associated tyrosine carboxypeptidase

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All nucleic 9

cDNA 8

Primer pair 1

Microarray probesets 5

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MGI:2142530, MGI:7388463

Summaries

All 30

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 5
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:325393 Landskron L, et al., Posttranslational modification of microtubules by the MATCAP detyrosinase. Science. 2022 May 20;376(6595):eabn6020

TSS for Matcap1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr82638	Chr8:106016507-106016518 (-)	-353 bp
Tssr82637	Chr8:106016097-106016173 (-)	25 bp
Tssr82636	Chr8:106015752-106015770 (-)	399 bp
Tssr82635	Chr8:106015716-106015746 (-)	429 bp
Tssr82634	Chr8:106015700-106015715 (-)	452 bp
Tssr82633	Chr8:106009870-106009908 (-)	6,271 bp
Tssr82632	Chr8:106009845-106009868 (-)	6,303 bp
Tssr82631	Chr8:106008122-106008140 (-)	8,029 bp
Tssr82630	Chr8:106008057-106008072 (-)	8,095 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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