Dpp8 MGI Mouse Gene Detail - MGI:1921638

Symbol

Dpp8
Name

dipeptidylpeptidase 8
Synonyms

2310004I03Rik, 4932434F09Rik

Feature Type

protein coding gene
IDs

MGI:1921638
NCBI Gene: 74388
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr9:64939696-64989933 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 35.06 cM, cytoband D
Mapping Data

3 experiments

SNPs within 2kb

1042 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921638	protein coding gene	Chr9:64939688-64991785 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034948	protein coding gene	Chr9:64729609-64783960 (+)
A/J	MGP_AJ_G0034928	protein coding gene	Chr9:62561190-62611776 (+)
AKR/J	MGP_AKRJ_G0034858	protein coding gene	Chr9:64028777-64080671 (+)
BALB/cJ	MGP_BALBcJ_G0034921	protein coding gene	Chr9:62282868-62333649 (+)
C3H/HeJ	MGP_C3HHeJ_G0034631	protein coding gene	Chr9:64551078-64604271 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035440	protein coding gene	Chr9:66508356-66561330 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032351	protein coding gene	Chr9:62200771-62253737 (+)
CAST/EiJ	MGP_CASTEiJ_G0033952	protein coding gene	Chr9:64734015-64787632 (+)
CBA/J	MGP_CBAJ_G0034602	protein coding gene	Chr9:68813868-68868724 (+)
DBA/2J	MGP_DBA2J_G0034761	protein coding gene	Chr9:62336613-62386681 (+)
FVB/NJ	MGP_FVBNJ_G0034703	protein coding gene	Chr9:61650482-61700636 (+)
LP/J	MGP_LPJ_G0034844	protein coding gene	Chr9:65010292-65061029 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034745	protein coding gene	Chr9:70067099-70124114 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035462	protein coding gene	Chr9:64140475-64191236 (+)
PWK/PhJ	MGP_PWKPhJ_G0033656	protein coding gene	Chr9:62514108-62566403 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033490	protein coding gene	Chr9:64401612-64460513 (+)
WSB/EiJ	MGP_WSBEiJ_G0034065	protein coding gene	Chr9:64035343-64085288 (+)

Human Ortholog

DPP8, dipeptidyl peptidase 8

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DPP8, dipeptidyl peptidase 8
Synonyms

DP8, DPRP-1, DPRP1, MST097, MSTP097, MSTP135, MSTP141
Links

HGNC:16490

NCBI Gene ID: 54878

neXtProt AC: NX_Q6V1X1

UniProt: Q6V1X1
Chr Location

15q22.31; chr15:65442463-65517704 (-) GRCh38

MGI Vertebrate Homology

Dpp8 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: DPP8
Gene Tree

Dpp8

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Phenotype Summary

15 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

5
Targeted

4
Genomic Mutations

1 involving Dpp8
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

59 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

12
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

737
Tissues

24
cDNA Data

12
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dpp8

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All Sequences

59
RefSeq

9
UniProt

3
CCDS

CCDS23285.1

Ensembl

ENSMUSG00000032393 (Evidence)
NCBI Gene

74388

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032393	Ensembl Gene Model \| MGI Sequence Detail	50238	C57BL/6J	± kb
transcript	ENSMUST00000167773	Ensembl \| MGI Sequence Detail	3142	Not Applicable
polypeptide	ENSMUSP00000126065	Ensembl \| MGI Sequence Detail	892	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006663 dipeptidyl peptidase 8

(term hierarchy)
EC

3.4.14.5
InterPro Domains

IPR029058 Alpha/Beta hydrolase fold

IPR045785 Dipeptidyl peptidase 8 /9 ,N-terminal

IPR002469 Dipeptidylpeptidase IV, N-terminal domain

IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain

IPR050278 Serine Protease S9B/DPPIV Subfamily

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All nucleic 15

cDNA 13

Primer pair 1

Other 1

Microarray probesets 7

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MGI:1923680, MGI:2143113

Summaries

All 42

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dpp8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr85654	Chr9:64939695-64939748 (+)	26 bp
Tssr85655	Chr9:64939752-64939773 (+)	67 bp
Tssr85656	Chr9:64939899-64939954 (+)	231 bp
Tssr85657	Chr9:64940015-64940041 (+)	332 bp
Tssr85658	Chr9:64940048-64940072 (+)	364 bp
Tssr85659	Chr9:64985164-64985169 (+)	45,471 bp
Tssr85660	Chr9:64985205-64985222 (+)	45,518 bp
Tssr85661	Chr9:64985259-64985270 (+)	45,569 bp
Tssr85662	Chr9:64989764-64989796 (+)	50,084 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24