Tmc5 MGI Mouse Gene Detail - MGI:1921674 - transmembrane channel-like gene family 5

Symbol

Tmc5
Name

transmembrane channel-like gene family 5
Synonyms

4932443L08Rik

Feature Type

protein coding gene
IDs

MGI:1921674
NCBI Gene: 74424
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr7:118196520-118274308 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 63.44 cM, cytoband F3
Mapping Data

3 experiments

SNPs within 2kb

2431 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921674	protein coding gene	Chr7:118196520-118274309 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032901	protein coding gene	Chr7:122446251-122535096 (+)
A/J	MGP_AJ_G0032884	protein coding gene	Chr7:119340451-119419851 (+)
AKR/J	MGP_AKRJ_G0032816	protein coding gene	Chr7:122382231-122473082 (+)
BALB/cJ	MGP_BALBcJ_G0032889	protein coding gene	Chr7:119056986-119136763 (+)
C3H/HeJ	MGP_C3HHeJ_G0032599	protein coding gene	Chr7:122282969-122367166 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033395	protein coding gene	Chr7:127336902-127429350 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030367	protein coding gene	Chr7:120777365-120855358 (+)
CAST/EiJ	MGP_CASTEiJ_G0031927	protein coding gene	Chr7:114028189-114122545 (+)
CBA/J	MGP_CBAJ_G0032572	protein coding gene	Chr7:131594361-131682936 (+)
DBA/2J	MGP_DBA2J_G0032724	protein coding gene	Chr7:117374302-117455159 (+)
FVB/NJ	MGP_FVBNJ_G0032677	protein coding gene	Chr7:117215674-117297571 (+)
LP/J	MGP_LPJ_G0032818	protein coding gene	Chr7:123908274-123998532 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032709	protein coding gene	Chr7:133079363-133167341 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033415	protein coding gene	Chr7:121378460-121471893 (+)
PWK/PhJ	MGP_PWKPhJ_G0031635	protein coding gene	Chr7:110275114-110357025 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031482	protein coding gene	Chr7:108108039-108195652 (+)
WSB/EiJ	MGP_WSBEiJ_G0032040	protein coding gene	Chr7:122265108-122352981 (+)

Human Ortholog

TMC5, transmembrane channel like 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMC5, transmembrane channel like 5
Links

HGNC:22999

NCBI Gene ID: 79838

neXtProt AC: NX_Q6UXY8

UniProt: Q6UXY8
Chr Location

16p12.3; chr16:19410496-19499113 (+) GRCh38

MGI Vertebrate Homology

Tmc5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMC5
Gene Tree

Tmc5

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

2
Gene trapped

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

2
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

859
Tissues

21
cDNA Data

20
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmc5

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All Sequences

52
RefSeq

10
UniProt

2
CCDS

CCDS21773.1, CCDS52374.1

Ensembl

ENSMUSG00000030650 (Evidence)
NCBI Gene

74424

			Length	Strain/Species	Flank
genomic	74424	NCBI Gene Model \| MGI Sequence Detail	77789	C57BL/6J	± kb
transcript	NM_001105252	RefSeq \| MGI Sequence Detail	3774	C57BL/6
polypeptide	Q32NZ6	UniProt \| EBI \| MGI Sequence Detail	967	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016396 transmembrane channel-like protein 5

(term hierarchy)
InterPro Domains

IPR012496 TMC domain

IPR038900 Transmembrane channel-like protein
GlyGen

Q32NZ6 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 21

cDNA 21

Microarray probesets 3

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MGI:3034686

Summaries

All 30

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tmc5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68717	Chr7:118196518-118196565 (+)	22 bp
Tssr68718	Chr7:118199375-118199396 (+)	2,866 bp
Tssr68719	Chr7:118199401-118199406 (+)	2,884 bp
Tssr68720	Chr7:118199417-118199427 (+)	2,902 bp
Tssr68721	Chr7:118199431-118199457 (+)	2,924 bp
Tssr68722	Chr7:118199459-118199487 (+)	2,953 bp
Tssr68723	Chr7:118232952-118232972 (+)	36,442 bp
Tssr68724	Chr7:118232975-118232989 (+)	36,462 bp
Tssr68725	Chr7:118248370-118248417 (+)	51,874 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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