Zfp558 MGI Mouse Gene Detail - MGI:1921681

Symbol

Zfp558
Name

zinc finger protein 558
Synonyms

1700007A21Rik, 4932704I17Rik, Zfp558-ps

Feature Type

protein coding gene
IDs

MGI:1921681
NCBI Gene: 72230
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr9:18366871-18389564 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 7.05 cM, cytoband A3
Mapping Data

2 experiments

SNPs within 2kb

814 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921681	protein coding gene	Chr9:18359983-18389597 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034376	protein coding gene	Chr9:15485964-15508460 (-)
A/J	MGP_AJ_G0034355	protein coding gene	Chr9:15356538-15381372 (-)
AKR/J	MGP_AKRJ_G0034283	protein coding gene	Chr9:15497758-15520968 (-)
BALB/cJ	MGP_BALBcJ_G0034347	protein coding gene	Chr9:15181763-15204244 (-)
C3H/HeJ	MGP_C3HHeJ_G0034060	protein coding gene	Chr9:15785502-15808560 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034870	protein coding gene	Chr9:16071756-16096771 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031807	protein coding gene	Chr9:14440273-14461637 (-)
CAST/EiJ	MGP_CASTEiJ_G0033386	protein coding gene	Chr9:15626986-15651970 (-)
CBA/J	MGP_CBAJ_G0034033	protein coding gene	Chr9:16745764-16773018 (-)
DBA/2J	MGP_DBA2J_G0034190	protein coding gene	Chr9:15207442-15230559 (-)
FVB/NJ	MGP_FVBNJ_G0034134	protein coding gene	Chr9:14766338-14789152 (-)
LP/J	MGP_LPJ_G0034276	protein coding gene	Chr9:15703195-15733464 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034179	protein coding gene	Chr9:17894283-17918713 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034889	protein coding gene	Chr9:15489202-15514545 (-)
PWK/PhJ	MGP_PWKPhJ_G0033092	protein coding gene	Chr9:15263633-15287062 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032927	protein coding gene	Chr9:15528972-15552695 (-)
WSB/EiJ	MGP_WSBEiJ_G0033503	protein coding gene	Chr9:15283849-15308239 (-)

Human Ortholog

ZNF557, zinc finger protein 557

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZNF557, zinc finger protein 557
Links

HGNC:28632

NCBI Gene ID: 79230

neXtProt AC: NX_Q8N988

UniProt: Q8N988
Chr Location

19p13.2; chr19:7069703-7087968 (+) GRCh38

Human Ortholog

ZNF558, zinc finger protein 558
Links

HGNC:26422

NCBI Gene ID: 148156

neXtProt AC: NX_Q96NG5

UniProt: Q96NG5
Chr Location

19p13.2; chr19:8806170-8838144 (-) GRCh38

MGI Vertebrate Homology

Zfp558 stringent orthology
2 human;1 mouse
HCOP

vertebrate homology predictions: ZNF557, ZNF558
Gene Tree

Zfp558

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

1
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

4
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

824
Tissues

109
cDNA Data

11
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

71
RefSeq

38
UniProt

3
CCDS

CCDS52729.1

Ensembl

ENSMUSG00000074500 (Evidence)
NCBI Gene

72230

			Length	Strain/Species	Flank
genomic	ENSMUSG00000074500	Ensembl Gene Model \| MGI Sequence Detail	22694	C57BL/6J	± kb
transcript	ENSMUST00000034647	Ensembl \| MGI Sequence Detail	1701	Not Applicable
polypeptide	ENSMUSP00000132305	Ensembl \| MGI Sequence Detail	407	Not Applicable

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UniProt

3 Sequences
InterPro Domains

IPR036051 KRAB domain superfamily

IPR001909 Krueppel-associated box

IPR050169 Krueppel C2H2-type zinc-finger

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 12

cDNA 11

Primer pair 1

Microarray probesets 3

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MGI:1919480

Summaries

All 25

Developmental Gene Expression 2

Gene Ontology 1

Phenotypes 4
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Zfp558:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr88286	Chr9:18389556-18389600 (-)	-14 bp
Tssr88285	Chr9:18384907-18384978 (-)	4,621 bp
Tssr88284	Chr9:18384863-18384878 (-)	4,693 bp
Tssr88283	Chr9:18380999-18381008 (-)	8,560 bp
Tssr88282	Chr9:18380978-18380996 (-)	8,577 bp
Tssr88281	Chr9:18380951-18380975 (-)	8,601 bp
Tssr88280	Chr9:18379488-18379499 (-)	10,070 bp
Tssr88279	Chr9:18379322-18379339 (-)	10,233 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24