Clvs1 MGI Mouse Gene Detail - MGI:1921688

Symbol

Clvs1
Name

clavesin 1
Synonyms

4933402J24Rik, Rlbp1l1

Feature Type

protein coding gene
IDs

MGI:1921688
NCBI Gene: 74438
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr4:9269293-9451691 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 4.07 cM, cytoband A1
Mapping Data

2 experiments

SNPs within 2kb

5649 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921688	protein coding gene	Chr4:9144753-9451691 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028041	protein coding gene	Chr4:5894354-6082656 (+)
A/J	MGP_AJ_G0027999	protein coding gene	Chr4:5744992-5928143 (+)
AKR/J	MGP_AKRJ_G0027965	protein coding gene	Chr4:5820487-6009586 (+)
BALB/cJ	MGP_BALBcJ_G0028011	protein coding gene	Chr4:5733012-5919445 (+)
C3H/HeJ	MGP_C3HHeJ_G0027741	protein coding gene	Chr4:5996882-6186247 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028454	protein coding gene	Chr4:6217070-6409267 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025798	protein coding gene	Chr4:5428035-5607287 (+)
CAST/EiJ	MGP_CASTEiJ_G0027195	protein coding gene	Chr4:5835757-6032366 (+)
CBA/J	MGP_CBAJ_G0027716	protein coding gene	Chr4:6304228-6508171 (+)
DBA/2J	MGP_DBA2J_G0027856	protein coding gene	Chr4:5715814-5903102 (+)
FVB/NJ	MGP_FVBNJ_G0027823	protein coding gene	Chr4:5597006-5778735 (+)
LP/J	MGP_LPJ_G0027967	protein coding gene	Chr4:5916624-6108637 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027856	protein coding gene	Chr4:6509717-6698488 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028513	protein coding gene	Chr4:5810182-6002993 (+)
PWK/PhJ	MGP_PWKPhJ_G0026916	protein coding gene	Chr4:5730124-5927502 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026746	protein coding gene	Chr4:5774828-5967997 (+)
WSB/EiJ	MGP_WSBEiJ_G0027274	protein coding gene	Chr4:5934691-6122238 (+)

Human Ortholog

CLVS1, clavesin 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CLVS1, clavesin 1
Synonyms

C6orf212L, CRALBPL, RLBP1L1
Links

HGNC:23139

NCBI Gene ID: 157807

neXtProt AC: NX_Q8IUQ0

UniProt: Q8IUQ0
Chr Location

8q12.2-q12.3; chr8:60964848-61501645 (+) GRCh38

MGI Vertebrate Homology

Clvs1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CLVS1
Gene Tree

Clvs1

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

16
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

746
Tissues

29
cDNA Data

13
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase clvs1

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All Sequences

57
RefSeq

14
UniProt

1
CCDS

CCDS17957.1

Ensembl

ENSMUSG00000041216 (Evidence)
NCBI Gene

74438

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041216	Ensembl Gene Model \| MGI Sequence Detail	182399	C57BL/6J	± kb
transcript	ENSMUST00000038841	Ensembl \| MGI Sequence Detail	3604	Not Applicable
polypeptide	ENSMUSP00000035649	Ensembl \| MGI Sequence Detail	354	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000014031 clavesin-1

(term hierarchy)
InterPro Domains

IPR001251 CRAL-TRIO lipid binding domain

IPR036865 CRAL-TRIO lipid binding domain superfamily

IPR011074 CRAL/TRIO, N-terminal domain

IPR036273 CRAL/TRIO, N-terminal domain superfamily

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All nucleic 17

cDNA 15

Primer pair 1

Other 1

Microarray probesets 3

Summaries

All 33

Developmental Gene Expression 5

Gene Ontology 5

Phenotypes 5
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Clvs1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr36453	Chr4:9269285-9269335 (+)	17 bp
Tssr36454	Chr4:9269338-9269362 (+)	57 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24