Pgs1 MGI Mouse Gene Detail - MGI:1921701 - phosphatidylglycerophosphate synthase 1

Symbol

Pgs1
Name

phosphatidylglycerophosphate synthase 1
Synonyms

2610019F11Rik, 4933424M23Rik

Feature Type

protein coding gene
IDs

MGI:1921701
NCBI Gene: 74451
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr11:117877118-117914837 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 82.96 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

871 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921701	protein coding gene	Chr11:117876505-117914837 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019460	protein coding gene	Chr11:122289825-122330363 (+)
A/J	MGP_AJ_G0019428	protein coding gene	Chr11:116863449-116901987 (+)
AKR/J	MGP_AKRJ_G0019398	protein coding gene	Chr11:120416285-120453794 (+)
BALB/cJ	MGP_BALBcJ_G0019403	protein coding gene	Chr11:117231380-117268999 (+)
C3H/HeJ	MGP_C3HHeJ_G0019209	protein coding gene	Chr11:120711467-120751538 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019852	protein coding gene	Chr11:126025947-126069117 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017477	protein coding gene	Chr11:113874425-113912214 (+)
CAST/EiJ	MGP_CASTEiJ_G0018763	protein coding gene	Chr11:122130970-122168874 (+)
CBA/J	MGP_CBAJ_G0019180	protein coding gene	Chr11:130962475-131007254 (+)
DBA/2J	MGP_DBA2J_G0019292	protein coding gene	Chr11:116256785-116294523 (+)
FVB/NJ	MGP_FVBNJ_G0019284	protein coding gene	Chr11:115886248-115925462 (+)
LP/J	MGP_LPJ_G0019362	protein coding gene	Chr11:122610577-122648156 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019317	protein coding gene	Chr11:129927571-129973382 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019891	protein coding gene	Chr11:121069028-121108943 (+)
PWK/PhJ	MGP_PWKPhJ_G0018529	protein coding gene	Chr11:117622379-117660220 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018321	protein coding gene	Chr11:120799804-120837229 (+)
WSB/EiJ	MGP_WSBEiJ_G0018815	protein coding gene	Chr11:121031627-121074554 (+)

Human Ortholog

PGS1, phosphatidylglycerophosphate synthase 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PGS1, phosphatidylglycerophosphate synthase 1
Links

HGNC:30029

NCBI Gene ID: 9489

neXtProt AC: NX_Q32NB8

UniProt: Q32NB8
Chr Location

17q25.3; chr17:78378649-78425114 (+) GRCh38

MGI Vertebrate Homology

Pgs1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PGS1
Protein SuperFamily

Phospholipase_D_PSS
Gene Tree

Pgs1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

58
Gene trapped

54
Targeted

4
Incidental Mutations

APF
Find Mice (IMSR)

52 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

13
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

821
Tissues

108
cDNA Data

81
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pgs1

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All Sequences

68
RefSeq

5
UniProt

6
CCDS

CCDS25698.1

Ensembl

ENSMUSG00000017715 (Evidence)
NCBI Gene

74451

			Length	Strain/Species	Flank
genomic	ENSMUSG00000017715	Ensembl Gene Model \| MGI Sequence Detail	37720	C57BL/6J	± kb
transcript	ENSMUST00000132676	Ensembl \| MGI Sequence Detail	2863	Not Applicable
polypeptide	ENSMUSP00000121973	Ensembl \| MGI Sequence Detail	553	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000012624 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

(term hierarchy)
EC

2.7.8.5
InterPro Domains

IPR016270 CDP-alcohol phosphatidyltransferase class-II family

IPR001736 Phospholipase D/Transphosphatidylase

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All nucleic 81

cDNA 81

Microarray probesets 7

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MGI:1919058

Summaries

All 42

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Pgs1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr106107	Chr11:117877664-117877725 (+)	577 bp
Tssr106108	Chr11:117877726-117877742 (+)	616 bp
Tssr106109	Chr11:117878115-117878137 (+)	1,008 bp
Tssr106110	Chr11:117878242-117878255 (+)	1,131 bp
Tssr106111	Chr11:117878259-117878285 (+)	1,154 bp
Tssr106112	Chr11:117878294-117878305 (+)	1,182 bp
Tssr106113	Chr11:117894344-117894348 (+)	17,228 bp
Tssr106114	Chr11:117895469-117895474 (+)	18,354 bp
Tssr106115	Chr11:117905370-117905403 (+)	28,269 bp
Tssr106116	Chr11:117905417-117905420 (+)	28,301 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24